AutismKB 2.0

Annotation Details for LRP6


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Basic Information Top
Gene Symbol:LRP6 ( ADCAD2,FLJ90062,FLJ90421 )
Gene Full Name: low density lipoprotein receptor-related protein 6
Band: 12p13.2
Quick LinksEntrez ID:4040; OMIM: 603507; Uniprot ID:LRP6_HUMAN; ENSEMBL ID: ENSG00000070018; HGNC ID: 6698
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005769IDAcolocalizes_withearly endosome16890161
GO:0005783IEA-endoplasmic reticulum-
GO:0005794IDAcolocalizes_withGolgi apparatus16890161
GO:0005886IDA-plasma membrane16263759
GO:0005886TAS-plasma membrane-
GO:0005901IDAcolocalizes_withcaveola16890161
GO:0009986IDA-cell surface12897152
GO:0016021IEA-integral component of membrane-
GO:0031410IDA-cytoplasmic vesicle16890161
GO:0031901TAS-early endosome membrane-
GO:0043025IBA-neuronal cell body-
GO:0043235IBA-receptor complex-
GO:0045202IBA-synapse-
GO:1990851IDA-Wnt-Frizzled-LRP5/6 complex20093360
GO:1990851IPI-Wnt-Frizzled-LRP5/6 complex11029007
GO:1990851TAS-Wnt-Frizzled-LRP5/6 complex22988876
GO:1990909IDA-Wnt signalosome22899650
GO:1990909NAS-Wnt signalosome24115276
GO ID Evidence Qualifier GO_term References
GO:0005041IDA-low-density lipoprotein receptor activity16263759
GO:0005102IPI-receptor binding14739301
GO:0005109IPI-frizzled binding11029007
GO:0005515IPI-protein binding11029007
GO:0017147IPI-Wnt-protein binding11029007
GO:0017147TAS-Wnt-protein binding22988876
GO:0019210IMP-kinase inhibitor activity16365045
GO:0019534IMP-toxin transporter activity16564009
GO:0019534IMPNOTtoxin transporter activity18350154
GO:0034185IBA-apolipoprotein binding-
GO:0042802IPI-identical protein binding12897152
GO:0042803IPI-protein homodimerization activity12897152
GO:0042813IBA-Wnt-activated receptor activity-
GO:0071936IDA-coreceptor activity involved in Wnt signaling pathway11029007
GO:1904928NAS-coreceptor activity involved in canonical Wnt signaling pathway24431302
GO ID Evidence Qualifier GO_term References
GO:0001843IBA-neural tube closure-
GO:0001933IMP-negative regulation of protein phosphorylation16365045
GO:0003344IBA-pericardium morphogenesis-
GO:0006469IMP-negative regulation of protein kinase activity16365045
GO:0007204IEA-positive regulation of cytosolic calcium ion concentration-
GO:0007268IBA-chemical synaptic transmission-
GO:0009880IBA-embryonic pattern specification-
GO:0014029IDA-neural crest formation11029007
GO:0014033IDA-neural crest cell differentiation11029007
GO:0016055IDA-Wnt signaling pathway11357136
GO:0016055IMP-Wnt signaling pathway11029007
GO:0016337IEA-single organismal cell-cell adhesion-
GO:0021587IBA-cerebellum morphogenesis-
GO:0021794IBA-thalamus development-
GO:0021987IBA-cerebral cortex development-
GO:0030917IBA-midbrain-hindbrain boundary development-
GO:0034392IMP-negative regulation of smooth muscle cell apoptotic process15271658
GO:0035261IBA-external genitalia morphogenesis-
GO:0042475IBA-odontogenesis of dentin-containing tooth-
GO:0043434IEA-response to peptide hormone-
GO:0044332IDA-Wnt signaling pathway involved in dorsal/ventral axis specification11029007
GO:0044335IC-canonical Wnt signaling pathway involved in neural crest cell differentiation11029007
GO:0044340IC-canonical Wnt signaling pathway involved in regulation of cell proliferation15271658
GO:0045787IMP-positive regulation of cell cycle15271658
GO:0045893IMP-positive regulation of transcription, DNA-templated18215320
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter12857724
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity14739301
GO:0060021IBA-palate development-
GO:0060026IBA-convergent extension-
GO:0060059IBA-embryonic retina morphogenesis in camera-type eye-
GO:0060070IDA-canonical Wnt signaling pathway12121999
GO:0060070IMP-canonical Wnt signaling pathway18215320
GO:0060070TAS-canonical Wnt signaling pathway22988876
GO:0060325IBA-face morphogenesis-
GO:0060535IBA-trachea cartilage morphogenesis-
GO:0060828IGI-regulation of canonical Wnt signaling pathway16805831
GO:0071397IMP-cellular response to cholesterol16890161
GO:0071542ISS-dopaminergic neuron differentiation-
GO:0071901IDA-negative regulation of protein serine/threonine kinase activity19107203
GO:0072659IPI-protein localization to plasma membrane22899650
GO:0090009IBA-primitive streak formation-
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
GO:0090118IBA-receptor-mediated endocytosis involved in cholesterol transport-
GO:0090244IBA-Wnt signaling pathway involved in somitogenesis-
GO:0090245IBA-axis elongation involved in somitogenesis-
GO:0090263IDA-positive regulation of canonical Wnt signaling pathway11448771
GO:1901998IEA-toxin transport-
GO:1904886TAS-beta-catenin destruction complex disassembly-
GO:1904948TAS-midbrain dopaminergic neuron differentiation22988876
GO:1904953TAS-Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation24431302
GO:2000055IDA-positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification15908424
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LRP6APOB11021918948618 Reconstituted Complex
LRP6APOB10683518948618 Reconstituted Complex
DKK1LRP611659911448771 Affinity Capture-Western
DKK1LRP611021911448771 Affinity Capture-Western
WNT1LRP611330811448771 Affinity Capture-Western
WNT1LRP611021911448771 Affinity Capture-Western
FZD8LRP611021911448771 Affinity Capture-Western
FZD8LRP611392111448771 Affinity Capture-Western
MESDC2LRP611021912581525 Affinity Capture-Western
MESDC2LRP611679412581525 Affinity Capture-Western
UBCLRP611021918378904 Affinity Capture-Western
UBCLRP611316418378904 Affinity Capture-Western
NPC1LRP611092518948618 Affinity Capture-Western
NPC1LRP611021918948618 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
LRP6rs1012672, rs2284396, rs2302685, rs2417086, rs7294695, rs7308022, rs7316466 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1298218
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090821-1'