AutismKB 2.0

Annotation Details for LRP5


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Basic Information Top
Gene Symbol:LRP5 ( BMND1,EVR1,EVR4,HBM,LR3,LRP7,OPPG,OPS,OPTA1,VBCH2 )
Gene Full Name: low density lipoprotein receptor-related protein 5
Band: 11q13.2
Quick LinksEntrez ID:4041; OMIM: 603506; Uniprot ID:LRP5_HUMAN; ENSEMBL ID: ENSG00000162337; HGNC ID: 6697
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IEA-mitochondrion-
GO:0005783IEA-endoplasmic reticulum-
GO:0005886IDA-plasma membrane17680723
GO:0005886TAS-plasma membrane-
GO:0016021IEA-integral component of membrane-
GO:0043235IDA-receptor complex18762581
GO:1990851TAS-Wnt-Frizzled-LRP5/6 complex20093360
GO:1990909NAS-Wnt signalosome24115276
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11336703
GO:0017147IPI-Wnt-protein binding11336703
GO:0017147ISS-Wnt-protein binding-
GO:0017147TAS-Wnt-protein binding22988876
GO:0019534IMPNOTtoxin transporter activity18350154
GO:0042813IBA-Wnt-activated receptor activity-
GO:0042813ISS-Wnt-activated receptor activity-
GO:0071936IPI-coreceptor activity involved in Wnt signaling pathway11336703
GO:1904928NAS-coreceptor activity involved in canonical Wnt signaling pathway24431302
GO ID Evidence Qualifier GO_term References
GO:0001702IEA-gastrulation with mouth forming second-
GO:0002053IMP-positive regulation of mesenchymal cell proliferation17680723
GO:0002076IBA-osteoblast development-
GO:0006007IMP-glucose catabolic process19673927
GO:0006897IEA-endocytosis-
GO:0008203IEA-cholesterol metabolic process-
GO:0008217IMP-regulation of blood pressure18721193
GO:0008284IDA-positive regulation of cell proliferation9790987
GO:0009314IEA-response to radiation-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0016055IDA-Wnt signaling pathway17955262
GO:0016055IGI-Wnt signaling pathway11336703
GO:0033690IEA-positive regulation of osteoblast proliferation-
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035426IEA-extracellular matrix-cell signaling-
GO:0042074IEA-cell migration involved in gastrulation-
GO:0042632IMP-cholesterol homeostasis18721193
GO:0042733IEA-embryonic digit morphogenesis-
GO:0042981IEA-regulation of apoptotic process-
GO:0043434IEA-response to peptide hormone-
GO:0044332IDA-Wnt signaling pathway involved in dorsal/ventral axis specification11029007
GO:0045600IMP-positive regulation of fat cell differentiation17680723
GO:0045668IMP-negative regulation of osteoblast differentiation17680723
GO:0045840IDA-positive regulation of mitotic nuclear division9790987
GO:0045893IDA-positive regulation of transcription, DNA-templated15035989
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter12857724
GO:0046849IEA-bone remodeling-
GO:0046850IEA-regulation of bone remodeling-
GO:0048539IMP-bone marrow development17680723
GO:0051091IEA-positive regulation of sequence-specific DNA binding transcription factor activity-
GO:0060033IEA-anatomical structure regression-
GO:0060042IMP-retina morphogenesis in camera-type eye15346351
GO:0060070IDA-canonical Wnt signaling pathway12121999
GO:0060070IMP-canonical Wnt signaling pathway19673927
GO:0060349IMP-bone morphogenesis19673927
GO:0060444IEA-branching involved in mammary gland duct morphogenesis-
GO:0060612IMP-adipose tissue development17680723
GO:0060764IEA-cell-cell signaling involved in mammary gland development-
GO:0060828IGI-regulation of canonical Wnt signaling pathway16805831
GO:0060828IMP-regulation of canonical Wnt signaling pathway18044981
GO:0061178IBA-regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0061304IMP-retinal blood vessel morphogenesis15024691
GO:0071901IMP-negative regulation of protein serine/threonine kinase activity19107203
GO:1902262IEA-apoptotic process involved in blood vessel morphogenesis-
GO:1904886TAS-beta-catenin destruction complex disassembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
AXIN1LRP511390911336703 18632848 Affinity Capture-Western
AXIN1LRP511022011336703 18632848 Affinity Capture-Western
FZD8LRP511392111448771 Affinity Capture-Western
FZD8LRP511022011448771 Affinity Capture-Western
MESDC2LRP511679412581525 Affinity Capture-Western
MESDC2LRP511022012581525 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1278315
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050518-2'