AutismKB 2.0

Annotation Details for ARNT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARNT ( HIF-1-beta,HIF-1beta,HIF1-beta,HIF1B,HIF1BETA,TANGO,bHLHe2 )
Gene Full Name: aryl hydrocarbon receptor nuclear translocator
Band: 1q21.3
Quick LinksEntrez ID:405; OMIM: 126110; Uniprot ID:ARNT_HUMAN; ENSEMBL ID: ENSG00000143437; HGNC ID: 700
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus8089148
GO:0005654TAS-nucleoplasm-
GO:0005737IEA-cytoplasm-
GO:0016604IDA-nuclear body-
GO:0090575IDA-RNA polymerase II transcription factor complex7539918
GO ID Evidence Qualifier GO_term References
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding1317062
GO:0003705IDAcontributes_totranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding7539918
GO:0003713IEA-transcription coactivator activity-
GO:0004874IEA-aryl hydrocarbon receptor activity-
GO:0005515IPI-protein binding9704006
GO:0008134IPI-transcription factor binding7539918
GO:0017162IPI-aryl hydrocarbon receptor binding9079689
GO:0035326IDA-enhancer binding23275542
GO:0043565IDAcontributes_tosequence-specific DNA binding7539918
GO:0046982IPI-protein heterodimerization activity9079689
GO ID Evidence Qualifier GO_term References
GO:0001666IDA-response to hypoxia8756616
GO:0001892IEA-embryonic placenta development-
GO:0001938IC-positive regulation of endothelial cell proliferation8756616
GO:0006351TAS-transcription, DNA-templated1317062
GO:0006805TAS-xenobiotic metabolic process-
GO:0010575IDA-positive regulation of vascular endothelial growth factor production8756616
GO:0030154IEA-cell differentiation-
GO:0030522IEA-intracellular receptor signaling pathway-
GO:0030949IC-positive regulation of vascular endothelial growth factor receptor signaling pathway8756616
GO:0033235IEA-positive regulation of protein sumoylation-
GO:0042789IC-mRNA transcription from RNA polymerase II promoter7539918
GO:0043619IDA-regulation of transcription from RNA polymerase II promoter in response to oxidative stress8089148
GO:0045648IC-positive regulation of erythrocyte differentiation1448077
GO:0045821IC-positive regulation of glycolytic process8089148
GO:0045893IDA-positive regulation of transcription, DNA-templated8089148
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046886IDA-positive regulation of hormone biosynthetic process1448077
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARNTAHR1066997488247 7628454 8384309 9887096 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARNTAHR1068987488247 7628454 8384309 9887096 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GTF2F1ARNT1092178794892 Reconstituted Complex
GTF2F1ARNT1068988794892 Reconstituted Complex
GTF2F2ARNT1068988794892 Reconstituted Complex
GTF2F2ARNT1092188794892 Reconstituted Complex
SIM1ARNT1068989020169 11782478 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIM1ARNT1123839020169 11782478 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIM2ARNT1068989020169 9271372 11782478 14701734 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIM2ARNT1123849020169 9271372 11782478 14701734 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HIF1AARNT1068989079689 11782478 15347669 20562859 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
HIF1AARNT1093389079689 11782478 15347669 20562859 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
EPAS1ARNT1068989079689 Reconstituted Complex; Two-hybrid
EPAS1ARNT1083489079689 Reconstituted Complex; Two-hybrid
AIPARNT1068989111057 11259606 Reconstituted Complex; Two-hybrid
AIPARNT1145119111057 11259606 Reconstituted Complex; Two-hybrid
RB1ARNT1068989712901 Affinity Capture-Western
RB1ARNT1118609712901 Affinity Capture-Western
AHRRARNT1068989887096 Affinity Capture-Western; Two-hybrid
AHRRARNT1215589887096 Affinity Capture-Western; Two-hybrid
SP1ARNT10689810471301 Reconstituted Complex
SP1ARNT11255010471301 Reconstituted Complex
HSP90AA1ARNT10689811013261 Affinity Capture-Western
HSP90AA1ARNT10955211013261 Affinity Capture-Western
PTGES3ARNT11595211259606 Reconstituted Complex
PTGES3ARNT10689811259606 Reconstituted Complex
SRCARNT10689812024042 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SRCARNT11259212024042 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA2ARNT10689812024042 Affinity Capture-Western; Two-hybrid
NCOA2ARNT11576112024042 Affinity Capture-Western; Two-hybrid
TAZARNT10689812065584 Affinity Capture-Western
TAZARNT11276412065584 Affinity Capture-Western
XPO1ARNT10689812065584 Affinity Capture-Western
XPO1ARNT11334812065584 Affinity Capture-Western
PMLARNT10689812354770 Reconstituted Complex
PMLARNT11138412354770 Reconstituted Complex
NPAS4ARNT12933514701734 Two-hybrid
NPAS4ARNT10689814701734 Two-hybrid
BRCA1ARNT10689816567799 Affinity Capture-Western; Reconstituted Complex
BRCA1ARNT10714016567799 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
EPAS1ARNT1931729113979 HLF interacts with Arnt. This interaction was modeled on a demonstrated interaction between mouse HLF and human Arnt.
NPAS1ARNT19745015635607 NPAS1 interacts with Arnt
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
ARNTrs2228099, rs3768012, rs3768013 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:88071
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved