AutismKB 2.0

Annotation Details for LTK


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Basic Information Top
Gene Symbol:LTK ( TYK1 )
Gene Full Name: leukocyte receptor tyrosine kinase
Band: 15q15.1
Quick LinksEntrez ID:4058; OMIM: 151520; Uniprot ID:LTK_HUMAN; ENSEMBL ID: ENSG00000062524; HGNC ID: 6721
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IEA-intracellular-
GO:0005886TAS-plasma membrane7685902
GO:0005887TAS-integral component of plasma membrane7685902
GO:0016020IDA-membrane10445845
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity10445845
GO:0004713TAS-protein tyrosine kinase activity7685902
GO:0004714IEA-transmembrane receptor protein tyrosine kinase activity-
GO:0005515IPI-protein binding26418745
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0006468IDA-protein phosphorylation9223670
GO:0007165TAS-signal transduction7685902
GO:0007169IEA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0008283IDA-cell proliferation10445845
GO:0010666IDA-positive regulation of cardiac muscle cell apoptotic process10445845
GO:0010976IMP-positive regulation of neuron projection development17910947
GO:0014065IMP-phosphatidylinositol 3-kinase signaling9223670
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0043066IMP-negative regulation of apoptotic process9223670
GO:0071300IMP-cellular response to retinoic acid17910947
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LTKCBL1073159223670 Biochemical Activity
LTKCBL1102369223670 Biochemical Activity
PIK3R1LTK1102368084603 9223670 Affinity Capture-Western
PIK3R1LTK1113138084603 9223670 Affinity Capture-Western
PLCG1LTK1113518084603 Affinity Capture-Western
PLCG1LTK1102368084603 Affinity Capture-Western
RAF1LTK1118318084603 Affinity Capture-Western
RAF1LTK1102368084603 Affinity Capture-Western
PTPN1LTK11173612237455 Protein-peptide
PTPN1LTK11023612237455 Protein-peptide
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96840
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030616-115'