AutismKB 2.0

Annotation Details for ARNTL


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Basic Information Top
Gene Symbol:ARNTL ( BMAL1,BMAL1c,JAP3,MGC47515,MOP3,PASD3,TIC,bHLHe5 )
Gene Full Name: aryl hydrocarbon receptor nuclear translocator-like
Band: 11p15.3
Quick LinksEntrez ID:406; OMIM: 602550; Uniprot ID:BMAL1_HUMAN; ENSEMBL ID: ENSG00000133794; HGNC ID: 701
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus24005054
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IPI-transcription factor complex9576906
GO:0016605IEA-PML body-
GO:0033391ISS-chromatoid body-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO ID Evidence Qualifier GO_term References
GO:0000976ISS-transcription regulatory region sequence-specific DNA binding-
GO:0000982ISS-transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001046IEA-core promoter sequence-specific DNA binding-
GO:0001047ISS-core promoter binding-
GO:0001190IEA-transcriptional activator activity, RNA polymerase II transcription factor binding-
GO:0003677IDA-DNA binding11441146
GO:0003677IGI-DNA binding9576906
GO:0005515IPI-protein binding14645221
GO:0017162IPI-aryl hydrocarbon receptor binding9079689
GO:0043425IEA-bHLH transcription factor binding-
GO:0043565ISS-sequence-specific DNA binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0051879IDA-Hsp90 protein binding9079689
GO:0070491IPI-repressing transcription factor binding25936801
GO:0070888IDA-E-box binding12738229
GO ID Evidence Qualifier GO_term References
GO:0000060IEA-protein import into nucleus, translocation-
GO:0006355ISS-regulation of transcription, DNA-templated-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007283ISS-spermatogenesis-
GO:0007623TAS-circadian rhythm-
GO:0032007ISS-negative regulation of TOR signaling-
GO:0032922IDA-circadian regulation of gene expression24005054
GO:0032922ISS-circadian regulation of gene expression-
GO:0042176IEA-regulation of protein catabolic process-
GO:0042634IMP-regulation of hair cycle24005054
GO:0042753ISS-positive regulation of circadian rhythm-
GO:0043161ISS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0045599ISS-negative regulation of fat cell differentiation-
GO:0045892ISS-negative regulation of transcription, DNA-templated-
GO:0045893IDA-positive regulation of transcription, DNA-templated11441146
GO:0045893IMP-positive regulation of transcription, DNA-templated21628546
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter20093779
GO:0045944IGI-positive regulation of transcription from RNA polymerase II promoter9576906
GO:0050767ISS-regulation of neurogenesis-
GO:0050796ISS-regulation of insulin secretion-
GO:0051726ISS-regulation of cell cycle-
GO:0051775IDA-response to redox state11441146
GO:0060137IEA-maternal process involved in parturition-
GO:0090263ISS-positive regulation of canonical Wnt signaling pathway-
GO:0090403ISS-oxidative stress-induced premature senescence-
GO:2000074ISS-regulation of type B pancreatic cell development-
GO:2000323ISS-negative regulation of glucocorticoid receptor signaling pathway-
GO:2000772ISS-regulation of cellular senescence-
GO:2001016ISS-positive regulation of skeletal muscle cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARNTLAHR1066999079689 Reconstituted Complex; Two-hybrid
ARNTLAHR1068999079689 Reconstituted Complex; Two-hybrid
HSP90AA1ARNTL1095529079689 Reconstituted Complex
HSP90AA1ARNTL1068999079689 Reconstituted Complex
EPAS1ARNTL1083489576906 Reconstituted Complex; Two-hybrid
EPAS1ARNTL1068999576906 Reconstituted Complex; Two-hybrid
HIF1AARNTL1093389576906 Reconstituted Complex; Two-hybrid
HIF1AARNTL1068999576906 Reconstituted Complex; Two-hybrid
NPAS2ARNTL1109239576906 11439184 Reconstituted Complex; Two-hybrid
NPAS2ARNTL1068999576906 11439184 Reconstituted Complex; Two-hybrid
CLOCKARNTL1068999576906 11439184 14701734 Two-hybrid
CLOCKARNTL1149449576906 11439184 14701734 Two-hybrid
CRY1ARNTL10779710531061 Two-hybrid
CRY1ARNTL10689910531061 Two-hybrid
RARAARNTL11184911439184 Reconstituted Complex
RARAARNTL10689911439184 Reconstituted Complex
RXRAARNTL10689911439184 Reconstituted Complex
RXRAARNTL11216811439184 Reconstituted Complex
CSNK1EARNTL10783811875063 Biochemical Activity
CSNK1EARNTL10689911875063 Biochemical Activity
EP300ARNTL10834714645221 Reconstituted Complex
EP300ARNTL10689914645221 Reconstituted Complex
KAT2BARNTL11437514645221 Reconstituted Complex
KAT2BARNTL10689914645221 Reconstituted Complex
NPAS4ARNTL12933514701734 Two-hybrid
NPAS4ARNTL10689914701734 Two-hybrid
UBCARNTL11316418644859 Affinity Capture-Western
UBCARNTL10689918644859 Affinity Capture-Western
SUMO3ARNTL11249618644859 Affinity Capture-Western; Biochemical Activity
SUMO3ARNTL10689918644859 Affinity Capture-Western; Biochemical Activity
SUMO2ARNTL11249718644859 Biochemical Activity
SUMO2ARNTL10689918644859 Biochemical Activity
SIRT1ARNTL11698318662547 Affinity Capture-Western; Biochemical Activity
SIRT1ARNTL10689918662547 Affinity Capture-Western; Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
ARNTLARNTL_22SNPs, rs1982350, rs2279287, rs2290035, rs2896635, rs895682 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1096381
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000509-1'