AutismKB 2.0

Annotation Details for LYN


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Basic Information Top
Gene Symbol:LYN ( FLJ26625,JTK8 )
Gene Full Name: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Band: 8q12.1
Quick LinksEntrez ID:4067; OMIM: 165120; Uniprot ID:LYN_HUMAN; ENSEMBL ID: ENSG00000147507,ENSG00000249529,ENSG00000250967; HGNC ID: 6735
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus18817770
GO:0005634ISS-nucleus-
GO:0005737ISS-cytoplasm-
GO:0005758IEA-mitochondrial intermembrane space-
GO:0005794IDA-Golgi apparatus15173188
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane15173188
GO:0005886TAS-plasma membrane-
GO:0005913IEA-cell-cell adherens junction-
GO:0014069IEA-postsynaptic density-
GO:0030061IEA-mitochondrial crista-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0034666IEA-integrin alpha2-beta1 complex-
GO:0042629IEA-mast cell granule-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0045121IDA-membrane raft11313396
GO:0048471IDA-perinuclear region of cytoplasm20605918
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004713EXP-protein tyrosine kinase activity1381360
GO:0004713IDA-protein tyrosine kinase activity7682714
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0004715TAS-non-membrane spanning protein tyrosine kinase activity-
GO:0004716TAS-signal transducer, downstream of receptor, with protein tyrosine kinase activity10748115
GO:0005102IBA-receptor binding-
GO:0005161IEA-platelet-derived growth factor receptor binding-
GO:0005178IEA-integrin binding-
GO:0005515IPI-protein binding1715582
GO:0005524IEA-ATP binding-
GO:0017124IEA-SH3 domain binding-
GO:0031625IEA-ubiquitin protein ligase binding-
GO:0043015IEA-gamma-tubulin binding-
GO:0043208IEA-glycosphingolipid binding-
GO:0044325IPI-ion channel binding12538589
GO:0051219IEA-phosphoprotein binding-
GO ID Evidence Qualifier GO_term References
GO:0001782ISS-B cell homeostasis-
GO:0001817ISS-regulation of cytokine production-
GO:0001932TAS-regulation of protein phosphorylation15489917
GO:0001933ISS-negative regulation of protein phosphorylation-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002250IEA-adaptive immune response-
GO:0002431IBA-Fc receptor mediated stimulatory signaling pathway-
GO:0002431ISS-Fc receptor mediated stimulatory signaling pathway-
GO:0002513ISS-tolerance induction to self antigen-
GO:0002513TAS-tolerance induction to self antigen15489917
GO:0002553IEA-histamine secretion by mast cell-
GO:0002576IBA-platelet degranulation-
GO:0002576ISS-platelet degranulation-
GO:0002762IEA-negative regulation of myeloid leukocyte differentiation-
GO:0002768ISS-immune response-regulating cell surface receptor signaling pathway-
GO:0002768TAS-immune response-regulating cell surface receptor signaling pathway15489917
GO:0002774ISS-Fc receptor mediated inhibitory signaling pathway-
GO:0002902IBA-regulation of B cell apoptotic process-
GO:0006468IDA-protein phosphorylation11517336
GO:0006954IBA-inflammatory response-
GO:0006974IDA-cellular response to DNA damage stimulus10891478
GO:0006991IEA-response to sterol depletion-
GO:0007165TAS-signal transduction7650013
GO:0007169IMP-transmembrane receptor protein tyrosine kinase signaling pathway14726379
GO:0007417IBA-central nervous system development-
GO:0007596TAS-blood coagulation-
GO:0008284ISS-positive regulation of cell proliferation-
GO:0008285IMP-negative regulation of cell proliferation14726379
GO:0009636IEA-response to toxic substance-
GO:0009725ISS-response to hormone-
GO:0009743IEA-response to carbohydrate-
GO:0010976IMP-positive regulation of neuron projection development17910947
GO:0014003IEA-oligodendrocyte development-
GO:0014070IEA-response to organic cyclic compound-
GO:0016032IEA-viral process-
GO:0018108IDA-peptidyl-tyrosine phosphorylation7682714
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030168TAS-platelet activation-
GO:0030218ISS-erythrocyte differentiation-
GO:0030335IEA-positive regulation of cell migration-
GO:0030889IBA-negative regulation of B cell proliferation-
GO:0031175IEA-neuron projection development-
GO:0031295TAS-T cell costimulation-
GO:0031663ISS-lipopolysaccharide-mediated signaling pathway-
GO:0031668IEA-cellular response to extracellular stimulus-
GO:0032868IEA-response to insulin-
GO:0033003ISS-regulation of mast cell activation-
GO:0033628IMP-regulation of cell adhesion mediated by integrin18802065
GO:0034136ISS-negative regulation of toll-like receptor 2 signaling pathway-
GO:0034144ISS-negative regulation of toll-like receptor 4 signaling pathway-
GO:0034605IEA-cellular response to heat-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042493IEA-response to drug-
GO:0042531ISS-positive regulation of tyrosine phosphorylation of STAT protein-
GO:0043200IEA-response to amino acid-
GO:0043304IBA-regulation of mast cell degranulation-
GO:0043304ISS-regulation of mast cell degranulation-
GO:0043407ISS-negative regulation of MAP kinase activity-
GO:0043552IEA-positive regulation of phosphatidylinositol 3-kinase activity-
GO:0045087IBA-innate immune response-
GO:0045646ISS-regulation of erythrocyte differentiation-
GO:0046777IDA-protein autophosphorylation7682714
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048678IEA-response to axon injury-
GO:0050663IEA-cytokine secretion-
GO:0050707IEA-regulation of cytokine secretion-
GO:0050727IEA-regulation of inflammatory response-
GO:0050777TAS-negative regulation of immune response15489917
GO:0050853IEA-B cell receptor signaling pathway-
GO:0050855IBA-regulation of B cell receptor signaling pathway-
GO:0050855ISS-regulation of B cell receptor signaling pathway-
GO:0050861IEA-positive regulation of B cell receptor signaling pathway-
GO:0050900TAS-leukocyte migration-
GO:0051272IDA-positive regulation of cellular component movement16467205
GO:0051279IEA-regulation of release of sequestered calcium ion into cytosol-
GO:0060252IEA-positive regulation of glial cell proliferation-
GO:0060369IEA-positive regulation of Fc receptor mediated stimulatory signaling pathway-
GO:0060397TAS-JAK-STAT cascade involved in growth hormone signaling pathway-
GO:0070304IDA-positive regulation of stress-activated protein kinase signaling cascade10891478
GO:0070372ISS-regulation of ERK1 and ERK2 cascade-
GO:0070373ISS-negative regulation of ERK1 and ERK2 cascade-
GO:0070447IEA-positive regulation of oligodendrocyte progenitor proliferation-
GO:0070667IBA-negative regulation of mast cell proliferation-
GO:0070667ISS-negative regulation of mast cell proliferation-
GO:0070668IMP-positive regulation of mast cell proliferation11435302
GO:0071300IMP-cellular response to retinoic acid17910947
GO:0090025IMP-regulation of monocyte chemotaxis18802065
GO:0090330IBA-regulation of platelet aggregation-
GO:0090330ISS-regulation of platelet aggregation-
GO:0097028IBA-dendritic cell differentiation-
GO:0097028ISS-dendritic cell differentiation-
GO:1902532ISS-negative regulation of intracellular signal transduction-
GO:2000670IBA-positive regulation of dendritic cell apoptotic process-
GO:2000670ISS-positive regulation of dendritic cell apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LYNFASLG10685217164290 Reconstituted Complex
LYNFASLG11024517164290 Reconstituted Complex
LYNBTK1071608058772 Reconstituted Complex
LYNBTK1102458058772 Reconstituted Complex
LYNCBL10731512244174 Affinity Capture-Western
LYNCBL11024512244174 Affinity Capture-Western
LYNCD2210737110228003 10748054 Affinity Capture-Western; Biochemical Activity
LYNCD2211024510228003 10748054 Affinity Capture-Western; Biochemical Activity
LYNCD361102451715582 Affinity Capture-Western
LYNCD361073861715582 Affinity Capture-Western
LYNCD721102459590210 Biochemical Activity
LYNCD721074099590210 Biochemical Activity
LYNCDK11102458051175 8910336 Affinity Capture-Western; Biochemical Activity
LYNCDK11074208051175 8910336 Affinity Capture-Western; Biochemical Activity
LYNCDK210745210432313 Affinity Capture-Western
LYNCDK211024510432313 Affinity Capture-Western
LYNCDK410745417353931 Affinity Capture-MS
LYNCDK411024517353931 Affinity Capture-MS
LYNCSF1R1078237636265 Affinity Capture-Western
LYNCSF1R1102457636265 Affinity Capture-Western
LYNCSF2RB1078267636265 9973406 Affinity Capture-Western; Protein-peptide
LYNCSF2RB1102457636265 9973406 Affinity Capture-Western; Protein-peptide
LYNCSF3R1078288197119 Affinity Capture-Western
LYNCSF3R1102458197119 Affinity Capture-Western
LYNCSNK2B10784314667819 Two-hybrid
LYNCSNK2B11024514667819 Two-hybrid
LYNCTLA41078759712716 Affinity Capture-Western
LYNCTLA41102459712716 Affinity Capture-Western
LYNDOK111024511071635 11825908 Biochemical Activity; Reconstituted Complex
LYNDOK110813111071635 11825908 Biochemical Activity; Reconstituted Complex
LYNEPOR1083719573010 Affinity Capture-Western; Reconstituted Complex
LYNEPOR1102459573010 Affinity Capture-Western; Reconstituted Complex
LYNPTK2B10848011311138 Affinity Capture-Western
LYNPTK2B11024511311138 Affinity Capture-Western
LYNFCAR1102459427690 Affinity Capture-Western
LYNFCAR1084989427690 Affinity Capture-Western
LYNFCGR2A1102459268059 Affinity Capture-Western
LYNFCGR2A1085069268059 Affinity Capture-Western
LYNHCLS11102457682714 Affinity Capture-Western
LYNHCLS11093097682714 Affinity Capture-Western
LYNINPP5D10984712882960 Affinity Capture-Western; Reconstituted Complex
LYNINPP5D11024512882960 Affinity Capture-Western; Reconstituted Complex
LYNJAK21099209573010 Reconstituted Complex
LYNJAK21102459573010 Reconstituted Complex
LYNKIT1100159341198 11825908 Affinity Capture-Western; Reconstituted Complex
LYNKIT1102459341198 11825908 Affinity Capture-Western; Reconstituted Complex
LYNLCP211012910026222 Affinity Capture-Western; Reconstituted Complex
LYNLCP211024510026222 Affinity Capture-Western; Reconstituted Complex
PTPRCLYN1102457516335 Affinity Capture-Western; Reconstituted Complex
PTPRCLYN1117527516335 Affinity Capture-Western; Reconstituted Complex
SHC1LYN1102457650013 Affinity Capture-Western
SHC1LYN1123617650013 Affinity Capture-Western
SYKLYN1102457831290 Affinity Capture-Western; Reconstituted Complex
SYKLYN1127177831290 Affinity Capture-Western; Reconstituted Complex
PLCG2LYN1102458395016 10981967 Affinity Capture-Western; Reconstituted Complex
PLCG2LYN1113528395016 10981967 Affinity Capture-Western; Reconstituted Complex
CD24LYN1073728753773 Affinity Capture-Western
CD24LYN1102458753773 Affinity Capture-Western
MMELYN1102458943850 Affinity Capture-Western
MMELYN1104558943850 Affinity Capture-Western
BCAR1LYN1102459020138 9581808 Affinity Capture-Western
BCAR1LYN1149349020138 9581808 Affinity Capture-Western
NEDD9LYN1102459020138 Affinity Capture-Western; Reconstituted Complex
NEDD9LYN1108169020138 Affinity Capture-Western; Reconstituted Complex
SRCLYN1102459169421 Protein-peptide
SRCLYN1125929169421 Protein-peptide
PTK2LYN1102459169439 Affinity Capture-Western
PTK2LYN1117199169439 Affinity Capture-Western
SKAP1LYN1102459195899 Reconstituted Complex
SKAP1LYN1141849195899 Reconstituted Complex
TYK2LYN1102459633884 Reconstituted Complex
TYK2LYN1131489633884 Reconstituted Complex
PRKDCLYN1102459748231 Reconstituted Complex
PRKDCLYN1115779748231 Reconstituted Complex
SKAP2LYN1102459837776 Affinity Capture-Western
SKAP2LYN1144489837776 Affinity Capture-Western
PDE4ALYN11024510206997 Reconstituted Complex
PDE4ALYN11116710206997 Reconstituted Complex
PIK3CGLYN11024510318860 Affinity Capture-Western
PIK3CGLYN11131210318860 Affinity Capture-Western
CBLCLYN11024510362357 Reconstituted Complex
CBLCLYN11715610362357 Reconstituted Complex
PTPN6LYN11024510574931 Reconstituted Complex
PTPN6LYN11174210574931 Reconstituted Complex
TRAT1LYN11024510790433 Reconstituted Complex
TRAT1LYN11915410790433 Reconstituted Complex
PAG1LYN11024510790433 Reconstituted Complex
PAG1LYN12093110790433 Reconstituted Complex
PECAM1LYN11024510858437 Affinity Capture-Western
PECAM1LYN11120110858437 Affinity Capture-Western
EVLLYN11024510945997 Reconstituted Complex
EVLLYN11955610945997 Reconstituted Complex
TECLYN11024511071635 Affinity Capture-Western
TECLYN11286511071635 Affinity Capture-Western
PPP1R8LYN11024511104670 Biochemical Activity
PPP1R8LYN11150311104670 Biochemical Activity
MAPK3LYN11024511131153 Affinity Capture-Western
MAPK3LYN11158111131153 Affinity Capture-Western
PRAM1LYN12389411301322 Affinity Capture-Western
PRAM1LYN11024511301322 Affinity Capture-Western
PPP1R15ALYN11024511517336 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPP1R15ALYN11717211517336 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NMT1LYN11024511594778 Biochemical Activity
NMT1LYN11089911594778 Biochemical Activity
GAB3LYN12658111739737 Reconstituted Complex
GAB3LYN11024511739737 Reconstituted Complex
BANK1LYN11024511782428 Affinity Capture-Western; Reconstituted Complex
BANK1LYN12035411782428 Affinity Capture-Western; Reconstituted Complex
GP6LYN11024511943772 Affinity Capture-Western; Reconstituted Complex
GP6LYN11937911943772 Affinity Capture-Western; Reconstituted Complex
GAB2LYN11024511971018 Affinity Capture-Western
GAB2LYN11518111971018 Affinity Capture-Western
RPL10LYN11024512138090 Reconstituted Complex
RPL10LYN11205412138090 Reconstituted Complex
UNC119LYN11024512496276 Affinity Capture-Western; Reconstituted Complex
UNC119LYN11454812496276 Affinity Capture-Western; Reconstituted Complex
TRPV4LYN11024512538589 Affinity Capture-Western; Biochemical Activity
TRPV4LYN12188312538589 Affinity Capture-Western; Biochemical Activity
MUC1LYN11024512750561 Affinity Capture-Western; Reconstituted Complex
MUC1LYN11066912750561 Affinity Capture-Western; Reconstituted Complex
RPS6KB1LYN11024516640565 Biochemical Activity
RPS6KB1LYN11211216640565 Biochemical Activity
RPS6KB2LYN11024516640565 Biochemical Activity
RPS6KB2LYN11211316640565 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96892
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040912-7'