AutismKB 2.0

Annotation Details for ARRB1


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Basic Information Top
Gene Symbol:ARRB1 ( ARB1,ARR1 )
Gene Full Name: arrestin, beta 1
Band: 11q13.4
Quick LinksEntrez ID:408; OMIM: 107940; Uniprot ID:ARRB1_HUMAN; ENSEMBL ID: ENSG00000137486; HGNC ID: 711
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0000785IDA-chromatin16325578
GO:0005634IDA-nucleus16325578
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm10823817
GO:0005765TAS-lysosomal membrane-
GO:0005829TAS-cytosol-
GO:0005834TAScolocalizes_withheterotrimeric G-protein complex10823817
GO:0005886TAS-plasma membrane9924018
GO:0005905IEA-clathrin-coated pit-
GO:0014069IEA-postsynaptic density-
GO:0016323IEA-basolateral plasma membrane-
GO:0016604IDA-nuclear body-
GO:0030659TAS-cytoplasmic vesicle membrane-
GO:0031143IEA-pseudopodium-
GO:0031410IDA-cytoplasmic vesicle15611106
GO:0043197IEA-dendritic spine-
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004402IDANOThistone acetyltransferase activity16325578
GO:0004857TAS-enzyme inhibitor activity2163110
GO:0005096IMP-GTPase activator activity15611106
GO:0005159IPI-insulin-like growth factor receptor binding15878855
GO:0005515IPI-protein binding16189514
GO:0008134IPI-transcription factor binding16325578
GO:0030331IEA-estrogen receptor binding-
GO:0031434IEA-mitogen-activated protein kinase kinase binding-
GO:0031625IPI-ubiquitin protein ligase binding15878855
GO:0031691IEA-alpha-1A adrenergic receptor binding-
GO:0031692IEA-alpha-1B adrenergic receptor binding-
GO:0031701IPI-angiotensin receptor binding15611106
GO:0031762IEA-follicle-stimulating hormone receptor binding-
GO:0031896IEA-V2 vasopressin receptor binding-
GO:0035612IEA-AP-2 adaptor complex binding-
GO:0035615IEA-clathrin adaptor activity-
GO:0043027IEA-cysteine-type endopeptidase inhibitor activity involved in apoptotic process-
GO:0044212IMP-transcription regulatory region DNA binding16325578
GO:0044325IEA-ion channel binding-
GO:0045309IEA-protein phosphorylated amino acid binding-
GO ID Evidence Qualifier GO_term References
GO:0000187IEA-activation of MAPK activity-
GO:0001934IMP-positive regulation of protein phosphorylation23633677
GO:0002031IMP-G-protein coupled receptor internalization10521508
GO:0002092IMP-positive regulation of receptor internalization22457824
GO:0006366IMP-transcription from RNA polymerase II promoter16325578
GO:0006915IEA-apoptotic process-
GO:0007602IEA-phototransduction-
GO:0015031IEA-protein transport-
GO:0016567IMP-protein ubiquitination15878855
GO:0030168TAS-platelet activation-
GO:0031397IDA-negative regulation of protein ubiquitination16378096
GO:0031398IEA-positive regulation of protein ubiquitination-
GO:0032088IDA-negative regulation of NF-kappaB transcription factor activity16378096
GO:0032092IEA-positive regulation of protein binding-
GO:0032715IDA-negative regulation of interleukin-6 production16378096
GO:0032717IDA-negative regulation of interleukin-8 production16378096
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0034260IEA-negative regulation of GTPase activity-
GO:0034393IEA-positive regulation of smooth muscle cell apoptotic process-
GO:0035025IMP-positive regulation of Rho protein signal transduction15611106
GO:0035066IMP-positive regulation of histone acetylation16325578
GO:0035774IEA-positive regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0042493IEA-response to drug-
GO:0042699IEA-follicle-stimulating hormone signaling pathway-
GO:0043149IMP-stress fiber assembly15611106
GO:0043154IEA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043161IMP-proteasome-mediated ubiquitin-dependent protein catabolic process15878855
GO:0043280IEA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter16325578
GO:0061024TAS-membrane organization-
GO:0070373IEA-negative regulation of ERK1 and ERK2 cascade-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade10644702
GO:0090240IMP-positive regulation of histone H4 acetylation16325578
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARRB1ADRB110690110862778 Reconstituted Complex
ARRB1ADRB110666210862778 Reconstituted Complex
ARRB1ARF610687711533043 Affinity Capture-Western; Reconstituted Complex
ARRB1ARF610690111533043 Affinity Capture-Western; Reconstituted Complex
ARRB1ARR310690017353931 Affinity Capture-MS
ARRB1ARR310690117353931 Affinity Capture-MS
NSFARRB110690110196135 Affinity Capture-Western
NSFARRB111096010196135 Affinity Capture-Western
CSKARRB110783210753943 Affinity Capture-Western
CSKARRB110690110753943 Affinity Capture-Western
CXCR2ARRB110979311170396 Affinity Capture-Western
CXCR2ARRB110690111170396 Affinity Capture-Western
OPRD1ARRB111103011259507 Affinity Capture-Western; Reconstituted Complex
OPRD1ARRB110690111259507 Affinity Capture-Western; Reconstituted Complex
MAPK10ARRB110690111356842 Affinity Capture-Western
MAPK10ARRB111158811356842 Affinity Capture-Western
CYTH2ARRB111468711533043 Affinity Capture-Western; Reconstituted Complex
CYTH2ARRB110690111533043 Affinity Capture-Western; Reconstituted Complex
DVL1ARRB110818811742073 Affinity Capture-Western
DVL1ARRB110690111742073 Affinity Capture-Western
DVL2ARRB110818911742073 Affinity Capture-Western; Two-hybrid
DVL2ARRB110690111742073 Affinity Capture-Western; Two-hybrid
CCR5ARRB110763912065593 Reconstituted Complex
CCR5ARRB110690112065593 Reconstituted Complex
RALGDSARRB110690112105416 Affinity Capture-Western
RALGDSARRB111183612105416 Affinity Capture-Western
PTHLHARRB111171612220636 Reconstituted Complex; Two-hybrid
PTHLHARRB110690112220636 Reconstituted Complex; Two-hybrid
MDM2ARRB111035812538596 18544533 Affinity Capture-Western
MDM2ARRB110690112538596 18544533 Affinity Capture-Western
ZBTB43ARRB111672716189514 Two-hybrid
ZBTB43ARRB110690116189514 Two-hybrid
GNMTARRB111808116189514 Two-hybrid
GNMTARRB110690116189514 Two-hybrid
CHD1ARRB110753017353931 Affinity Capture-MS
CHD1ARRB110690117353931 Affinity Capture-MS
CMBLARRB110690117353931 Affinity Capture-MS
CMBLARRB112638717353931 Affinity Capture-MS
CSNK2A1ARRB110784117353931 Affinity Capture-MS
CSNK2A1ARRB110690117353931 Affinity Capture-MS
RTF1ARRB111678017353931 Affinity Capture-MS
RTF1ARRB110690117353931 Affinity Capture-MS
BOP1ARRB111685017353931 Affinity Capture-MS
BOP1ARRB110690117353931 Affinity Capture-MS
PES1ARRB111704017353931 Affinity Capture-MS
PES1ARRB110690117353931 Affinity Capture-MS
RPL7L1ARRB113023417353931 Affinity Capture-MS
RPL7L1ARRB110690117353931 Affinity Capture-MS
JAK1ARRB110991917353931 Affinity Capture-MS
JAK1ARRB110690117353931 Affinity Capture-MS
KHKARRB110690117353931 Affinity Capture-MS
KHKARRB110999617353931 Affinity Capture-MS
KPNA3ARRB111003717353931 Affinity Capture-MS
KPNA3ARRB110690117353931 Affinity Capture-MS
ARRB2ARRB110690217353931 Affinity Capture-MS
ARRB2ARRB110690117353931 Affinity Capture-MS
DDX27ARRB112079317353931 Affinity Capture-MS
DDX27ARRB110690117353931 Affinity Capture-MS
CCL14ARRB111226117353931 Affinity Capture-MS
CCL14ARRB110690117353931 Affinity Capture-MS
TCOF1ARRB110690117353931 Affinity Capture-MS
TCOF1ARRB111280917353931 Affinity Capture-MS
HDGFRP2ARRB112422117353931 Affinity Capture-MS
HDGFRP2ARRB110690117353931 Affinity Capture-MS
AP3B1ARRB110690117353931 Affinity Capture-MS
AP3B1ARRB111411617353931 Affinity Capture-MS
NOLC1ARRB110690117353931 Affinity Capture-MS
NOLC1ARRB111465417353931 Affinity Capture-MS
ZRANB2ARRB110690117353931 Affinity Capture-MS
ZRANB2ARRB111480217353931 Affinity Capture-MS
NEDD4ARRB110690118544533 Affinity Capture-Western
NEDD4ARRB111081118544533 Affinity Capture-Western
ITCHARRB110690118544533 Affinity Capture-Western
ITCHARRB112374718544533 Affinity Capture-Western
JUNARRB110992820936779 Two-hybrid
JUNARRB110690120936779 Two-hybrid
SREBF2ARRB111259920936779 Two-hybrid
SREBF2ARRB110690120936779 Two-hybrid
CDC42ARRB110743320936779 Two-hybrid
CDC42ARRB110690120936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
SLC9A5ARRB126228015699339 An unspecified isoform of Beta-Arr1 interacts with NHE5.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99473
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060824-1'