AutismKB 2.0

Annotation Details for MAD2L1


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Basic Information Top
Gene Symbol:MAD2L1 ( HSMAD2,MAD2 )
Gene Full Name: MAD2 mitotic arrest deficient-like 1 (yeast)
Band: 4q27
Quick LinksEntrez ID:4085; OMIM: 601467; Uniprot ID:MD2L1_HUMAN; ENSEMBL ID: ENSG00000164109; HGNC ID: 6763
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000776IDA-kinetochore19229290
GO:0000776IDAcolocalizes_withkinetochore8824189
GO:0000777IEA-condensed chromosome kinetochore-
GO:0000922IEA-spindle pole-
GO:0005634IDA-nucleus18981471
GO:0005643IDAcolocalizes_withnuclear pore18981471
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol18981471
GO:0005829TAS-cytosol-
GO:0048471IDA-perinuclear region of cytoplasm8824189
GO:0072686IDA-mitotic spindle20133940
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding10200259
GO:0042802IPI-identical protein binding16525508
GO:0042803IPI-protein homodimerization activity18022367
GO ID Evidence Qualifier GO_term References
GO:0000070IEA-mitotic sister chromatid segregation-
GO:0007062TAS-sister chromatid cohesion-
GO:0007093IDA-mitotic cell cycle checkpoint8824189
GO:0007093IGI-mitotic cell cycle checkpoint21274008
GO:0007094IEA-mitotic spindle assembly checkpoint-
GO:0031145TAS-anaphase-promoting complex-dependent catabolic process-
GO:0042177IDA-negative regulation of protein catabolic process11459825
GO:0042787TAS-protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:0043066IMP-negative regulation of apoptotic process20870947
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0045930IMP-negative regulation of mitotic cell cycle21274008
GO:0051301IEA-cell division-
GO:0051436TAS-negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0090267IMP-positive regulation of mitotic cell cycle spindle assembly checkpoint20870947
GO:1904667IDA-negative regulation of ubiquitin protein ligase activity11459825
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAD2L1ADAM1011026011741929 Affinity Capture-Western
MAD2L1ADAM1010661611741929 Affinity Capture-Western
MAD2L1APC1068219637688 Affinity Capture-Western
MAD2L1APC1102609637688 Affinity Capture-Western
MAD2L1BUB1B10716611535616 Affinity Capture-Western; Co-purification
MAD2L1BUB1B11026011535616 Affinity Capture-Western; Co-purification
MAD2L1CDC201074279628895 9637688 9736712 10700282 11274370 11438673 11707408 12196507 14561775 14607335 17443180 18592005 18997788 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MAD2L1CDC201102609628895 9637688 9736712 10700282 11274370 11438673 11707408 12196507 14561775 14607335 17443180 18592005 18997788 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MAD2L1CDC271074319628895 9736712 Affinity Capture-Western
MAD2L1CDC271102609628895 9736712 Affinity Capture-Western
MAD2L1CSF2RB10782611551900 Affinity Capture-Western; Reconstituted Complex
MAD2L1CSF2RB11026011551900 Affinity Capture-Western; Reconstituted Complex
MAD2L1ESR210840410706629 Reconstituted Complex; Two-hybrid
MAD2L1ESR211026010706629 Reconstituted Complex; Two-hybrid
UBDMAD2L111026010200259 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBDMAD2L111579110200259 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAD2L111273110527948 11741929 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAD2L111026010527948 11741929 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAD2L2MAD2L111026010660610 Reconstituted Complex
MAD2L2MAD2L111572210660610 Reconstituted Complex
REV3LMAD2L111191210660610 Reconstituted Complex
REV3LMAD2L111026010660610 Reconstituted Complex
MAD1L1MAD2L111397110660610 11707408 16189514 Reconstituted Complex; Two-hybrid
MAD1L1MAD2L111026010660610 11707408 16189514 Reconstituted Complex; Two-hybrid
ADAM15MAD2L111428711741929 Affinity Capture-Western
ADAM15MAD2L111026011741929 Affinity Capture-Western
MAD2L1BPMAD2L111026012456649 Affinity Capture-Western
MAD2L1BPMAD2L111495512456649 Affinity Capture-Western
TSC22D4MAD2L111026016189514 Two-hybrid
TSC22D4MAD2L112356316189514 Two-hybrid
DSTYKMAD2L111026017353931 Affinity Capture-MS
DSTYKMAD2L111731317353931 Affinity Capture-MS
UBE2CMAD2L111624917443186 Co-fractionation
UBE2CMAD2L111026017443186 Co-fractionation
CHFRMAD2L111026018592005 Affinity Capture-Western
CHFRMAD2L112086118592005 Affinity Capture-Western
KLHL13MAD2L111026019615732 Affinity Capture-MS
KLHL13MAD2L112468819615732 Affinity Capture-MS
KEAP1MAD2L111026019615732 Affinity Capture-MS
KEAP1MAD2L111515619615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1860374
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030515-3'