AutismKB 2.0

Annotation Details for SMAD6


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Basic Information Top
Gene Symbol:SMAD6 ( HsT17432,MADH6,MADH7 )
Gene Full Name: SMAD family member 6
Band: 15q22.31
Quick LinksEntrez ID:4091; OMIM: 602931; Uniprot ID:SMAD6_HUMAN; ENSEMBL ID: ENSG00000137834; HGNC ID: 6772
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16491121
GO:0005667IEA-transcription factor complex-
GO:0005737TAS-cytoplasm19018011
GO:0005794IDA-Golgi apparatus-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016604IDA-nuclear body-
GO:0043234IDA-protein complex23610558
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding16491121
GO:0003682IDA-chromatin binding16491121
GO:0003700IEA-transcription factor activity, sequence-specific DNA binding-
GO:0005515IPI-protein binding9436979
GO:0030617IDA-transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity9256479
GO:0030617IMP-transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity19047146
GO:0031625IPI-ubiquitin protein ligase binding11278251
GO:0034713IDA-type I transforming growth factor beta receptor binding9436979
GO:0042802IPI-identical protein binding9436979
GO:0044212IDA-transcription regulatory region DNA binding16491121
GO:0046872IEA-metal ion binding-
GO:0070410IPI-co-SMAD binding9256479
GO:0070411IPI-I-SMAD binding9256479
GO:0070412IPI-R-SMAD binding9256479
GO:0070698IDA-type I activin receptor binding9436979
GO ID Evidence Qualifier GO_term References
GO:0001657IEA-ureteric bud development-
GO:0003148ISS-outflow tract septum morphogenesis-
GO:0003183ISS-mitral valve morphogenesis-
GO:0003184ISS-pulmonary valve morphogenesis-
GO:0003281IEA-ventricular septum development-
GO:0006351IEA-transcription, DNA-templated-
GO:0006955IMP-immune response16886151
GO:0007179IEA-transforming growth factor beta receptor signaling pathway-
GO:0007352IMP-zygotic specification of dorsal/ventral axis9436979
GO:0008285IMP-negative regulation of cell proliferation19047146
GO:0010991IDA-negative regulation of SMAD protein complex assembly9436979
GO:0030279ISS-negative regulation of ossification-
GO:0030509IDA-BMP signaling pathway23455153
GO:0030509TAS-BMP signaling pathway-
GO:0030512IMP-negative regulation of transforming growth factor beta receptor signaling pathway19047146
GO:0030514IDA-negative regulation of BMP signaling pathway9436979
GO:0031589IMP-cell-substrate adhesion16491121
GO:0034616IEP-response to laminar fluid shear stress9256479
GO:0035904IEA-aorta development-
GO:0043066IMP-negative regulation of apoptotic process19047146
GO:0043627IEA-response to estrogen-
GO:0045444IDA-fat cell differentiation23455153
GO:0060394IDA-negative regulation of pathway-restricted SMAD protein phosphorylation9436979
GO:0060394IMP-negative regulation of pathway-restricted SMAD protein phosphorylation19047146
GO:0060976IEA-coronary vasculature development-
GO:1902895IEA-positive regulation of pri-miRNA transcription from RNA polymerase II promoter-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SMAD6CTBP111026614645520 Affinity Capture-Western
SMAD6CTBP110786914645520 Affinity Capture-Western
SMAD6HOXC811026610722652 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD6HOXC810946410722652 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD6SMAD11102619256479 Affinity Capture-Western
SMAD6SMAD11102669256479 Affinity Capture-Western
SMAD6SMAD21102669256479 Affinity Capture-Western
SMAD6SMAD21102629256479 Affinity Capture-Western
SMAD6SMAD41102669256479 15817471 Affinity Capture-Western
SMAD6SMAD41102649256479 15817471 Affinity Capture-Western
SMAD7SMAD61102679256479 Affinity Capture-Western; Two-hybrid
SMAD7SMAD61102669256479 Affinity Capture-Western; Two-hybrid
MAP3K7SMAD611026610748100 11737269 Affinity Capture-Western
MAP3K7SMAD611274810748100 11737269 Affinity Capture-Western
STRAPSMAD611026610757800 Affinity Capture-Western
STRAPSMAD611634210757800 Affinity Capture-Western
STAMBPSMAD611026611483516 Affinity Capture-Western
STAMBPSMAD611586311483516 Affinity Capture-Western
TAB1SMAD611026611737269 Affinity Capture-Western
TAB1SMAD611571711737269 Affinity Capture-Western
YAP1SMAD611026612118366 Affinity Capture-Western
YAP1SMAD611568412118366 Affinity Capture-Western
PIAS4SMAD611026612815042 Affinity Capture-Western; Two-hybrid
PIAS4SMAD611962412815042 Affinity Capture-Western; Two-hybrid
RNF111SMAD611026614657019 Affinity Capture-Western
RNF111SMAD612014614657019 Affinity Capture-Western
WWP1SMAD611026615221015 Affinity Capture-Western
WWP1SMAD611624315221015 Affinity Capture-Western
SMURF1SMAD611026615221015 Affinity Capture-Western
SMURF1SMAD612141115221015 Affinity Capture-Western
SMURF2SMAD611026615221015 Affinity Capture-Western
SMURF2SMAD612226515221015 Affinity Capture-Western
UBCSMAD611026615221015 Affinity Capture-Western
UBCSMAD611316415221015 Affinity Capture-Western
NEDD4SMAD611026615496141 Affinity Capture-Western
NEDD4SMAD611081115496141 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1336883
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-011015-1'