AutismKB 2.0

Annotation Details for MAPT


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Basic Information Top
Gene Symbol:MAPT ( DDPAC,FLJ31424,FTDP-17,MAPTL,MGC138549,MSTD,MTBT1,MTBT2,PPND,TAU )
Gene Full Name: microtubule-associated protein tau
Band: 17q21.31
Quick LinksEntrez ID:4137; OMIM: 157140; Uniprot ID:TAU_HUMAN; ENSEMBL ID: ENSG00000186868; HGNC ID: 6893
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005737IDA-cytoplasm27356871
GO:0005829IDA-cytosol10747907
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005874NAS-microtubule26363795
GO:0005875IBA-microtubule associated complex-
GO:0005886IDA-plasma membrane8522593
GO:0015630IDA-microtubule cytoskeleton15147841
GO:0016020IMPcolocalizes_withmembrane20655099
GO:0016607IDA-nuclear speck-
GO:0030424IDA-axon8642405
GO:0030424NAS-axon26363795
GO:0030425IDA-dendrite25620700
GO:0030426IDA-growth cone8642405
GO:0030673IDA-axolemma10747907
GO:0034399IDA-nuclear periphery19157893
GO:0036464IDA-cytoplasmic ribonucleoprotein granule15121898
GO:0036477IMP-somatodendritic compartment20655099
GO:0043025IMP-neuronal cell body20655099
GO:0044297IDA-cell body25620700
GO:0045298IDA-tubulin complex8642405
GO:0097418IDA-neurofibrillary tangle2484340
GO:0097418NAS-neurofibrillary tangle25620700
GO:1904115IEA-axon cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0003677ISS-DNA binding-
GO:0003779TAS-actin binding22920254
GO:0005515IPI-protein binding3111527
GO:0008017IDA-microtubule binding1918161
GO:0008017IMP-microtubule binding10747907
GO:0008017TAS-microtubule binding26363795
GO:0017124IPI-SH3 domain binding9763511
GO:0019899IPI-enzyme binding9736630
GO:0034185IPI-apolipoprotein binding7566652
GO:0034452TAS-dynactin binding26363795
GO:0042802IMP-identical protein binding7929085
GO:0042803IMP-protein homodimerization activity15654759
GO:0048018IDA-receptor agonist activity18272392
GO:0048018TAS-receptor agonist activity26363795
GO:0051721TAS-protein phosphatase 2A binding26363795
GO:0051879ISS-Hsp90 protein binding-
GO:0071813IPI-lipoprotein particle binding7972031
GO:0099609IMP-microtubule lateral binding15147841
GO ID Evidence Qualifier GO_term References
GO:0000226IDA-microtubule cytoskeleton organization1057175
GO:0001774TAS-microglial cell activation26363795
GO:0006919TAS-activation of cysteine-type endopeptidase activity involved in apoptotic process26363795
GO:0007165IEA-signal transduction-
GO:0007613IMP-memory20655099
GO:0010506IGI-regulation of autophagy19074461
GO:0010629IMP-negative regulation of gene expression23164821
GO:0010917IMP-negative regulation of mitochondrial membrane potential22920254
GO:0019896TAS-axonal transport of mitochondrion26363795
GO:0031110IMP-regulation of microtubule polymerization or depolymerization27356871
GO:0031113NAS-regulation of microtubule polymerization1057175
GO:0031116IDA-positive regulation of microtubule polymerization1421571
GO:0031122TAS-cytoplasmic microtubule organization26363795
GO:0031175TAS-neuron projection development26363795
GO:0032930IMP-positive regulation of superoxide anion generation22920254
GO:0033673IMP-negative regulation of kinase activity20655099
GO:0034605TAS-cellular response to heat26363795
GO:0045773IDA-positive regulation of axon extension1389180
GO:0048143TAS-astrocyte activation26363795
GO:0048312IMP-intracellular distribution of mitochondria21854751
GO:0048699NAS-generation of neurons8522593
GO:0050808IMP-synapse organization17270732
GO:0050848IDA-regulation of calcium-mediated signaling18272392
GO:0051259TAS-protein oligomerization26363795
GO:0070507IMP-regulation of microtubule cytoskeleton organization15147841
GO:0072386TAS-plus-end-directed organelle transport along microtubule26363795
GO:0090140IC-regulation of mitochondrial fission22367970
GO:0090258IMP-negative regulation of mitochondrial fission22920254
GO:0097435IMP-supramolecular fiber organization14769047
GO:0098930TAS-axonal transport26363795
GO:1900034IMP-regulation of cellular response to heat21131359
GO:1901216IMP-positive regulation of neuron death22920254
GO:1902474IMP-positive regulation of protein localization to synapse20655099
GO:1902988NAS-neurofibrillary tangle assembly26363795
GO:1903748IMP-negative regulation of establishment of protein localization to mitochondrion22920254
GO:1903829IMP-positive regulation of cellular protein localization27356871
GO:1905689ISS-positive regulation of diacylglycerol kinase activity-
GO:1990000IMP-amyloid fibril formation7929085
GO:2000273IEA-positive regulation of receptor activity-
GO:2001020IMP-regulation of response to DNA damage stimulus21131359
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAPTAPOE1103088620924 Reconstituted Complex
MAPTAPOE1068458620924 Reconstituted Complex
MAPTBAG111030817954934 Affinity Capture-Western; Reconstituted Complex
MAPTBAG110704917954934 Affinity Capture-Western; Reconstituted Complex
MAPTCALM11103082123288 Reconstituted Complex
MAPTCALM11072522123288 Reconstituted Complex
MAPTFYN10881011826099 Affinity Capture-Western; Reconstituted Complex
MAPTFYN11030811826099 Affinity Capture-Western; Reconstituted Complex
MAPTHSPA411030814962978 Affinity Capture-Western
MAPTHSPA410954014962978 Affinity Capture-Western
MAPTHSPA811030817954934 Affinity Capture-Western
MAPTHSPA810954417954934 Affinity Capture-Western
S100BMAPT1103082833519 11264299 Reconstituted Complex
S100BMAPT1121932833519 11264299 Reconstituted Complex
PSEN1MAPT1103089689133 Co-fractionation
PSEN1MAPT1116429689133 Co-fractionation
PIN1MAPT11030810391244 Reconstituted Complex
PIN1MAPT11131710391244 Reconstituted Complex
SNCAMAPT11030810464279 Co-purification; Reconstituted Complex
SNCAMAPT11250610464279 Co-purification; Reconstituted Complex
YWHABMAPT11030810840038 12176984 Affinity Capture-Western
YWHABMAPT11336110840038 12176984 Affinity Capture-Western
YWHAZMAPT11030810840038 Affinity Capture-Western; Reconstituted Complex
YWHAZMAPT11336610840038 Affinity Capture-Western; Reconstituted Complex
STXBP1MAPT11030812963086 Affinity Capture-Western
STXBP1MAPT11268112963086 Affinity Capture-Western
MARK4MAPT11030814594945 Biochemical Activity
MARK4MAPT12176014594945 Biochemical Activity
AATFMAPT11030814697667 FRET
AATFMAPT11774314697667 FRET
PARK2MAPT11030814962978 18248624 Affinity Capture-Western
PARK2MAPT11110514962978 18248624 Affinity Capture-Western
UBCMAPT11030814962978 15447663 18292230 Affinity Capture-Western
UBCMAPT11316414962978 15447663 18292230 Affinity Capture-Western
STUB1MAPT11030814962978 15447663 18292230 Affinity Capture-Western; Biochemical Activity
STUB1MAPT11556314962978 15447663 18292230 Affinity Capture-Western; Biochemical Activity
OGTMAPT11030816434389 Biochemical Activity
OGTMAPT11404916434389 Biochemical Activity
HDAC6MAPT11030818636984 Affinity Capture-Western; Reconstituted Complex
HDAC6MAPT11533018636984 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
MAPT/STH148T->C (exon 14), 159G->A (exon 9), 227G-T (exon 14), 254G->A (exon 9), 482C->T (exon 4A), H47Y, MAPT_H1H2, MAPT_VNTR, rs1078268, rs1078997, rs11867549, rs12938245, rs1467967, rs16940742, rs17563986, rs1864325, rs1981997, rs2258689, rs242557, rs2435200, rs2435205, rs2435211, rs2471738, rs3744456, rs3785880, rs3785883, rs4792891, rs4792893, rs4792894, rs7220988, rs7521, rs8070723, rs8078967, rs8079215, rs9891103 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
MAPT/STHMAPT_-226C/G, MAPT_-349T/C, MAPT_-373G/C-MspI, MAPT_-45A/G, MAPT_-568indel, MAPT_-592indel, MAPT_-623indel, MAPT_-639C/T, MAPT_108C/T, MAPT_110173G/A, MAPT_199deltaC, MAPT_238bp-indel, MAPT_H1-SNP12, MAPT_H1-SNP4, MAPT_H1-SNP5, MAPT_H1H2, MAPT_SNP-BanII-exon3, MAPT_SNP-Tsp509I, MAPT_indel-intron10, hCV3202946, rs10514889, rs1052553, rs11568305, rs11867549, rs12150530, rs1467966, rs1467967, rs1560310, rs17563965, rs17563986, rs17564829, rs17571857, rs17573266, rs17649641, rs17650417, rs17650901, rs17651549, rs17691610, rs1800547, rs1880753, rs1880756, rs1981997, rs1991556, rs199533, rs2258689, rs242556, rs242557, rs242559, rs242562, rs242928, rs2435205, rs2435207, rs2435211, rs2435214, rs2471738, rs35908989, rs3744456, rs3744457, rs3744460, rs3785880, rs3785883, rs393152, rs41543317, rs41543512, rs4792894, rs62063786, rs62063787, rs62063857, rs63750222, rs6503453, rs7215239, rs72293848, rs7521, rs754593, rs767057, rs8070723, rs9468, rs9891103 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
MAPTrs1467970, rs2258689, rs2435211, rs3785880, rs3785883, rs4792893, rs878918 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97180
  • Data Attributes: MGI curated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081027-1'