Gene Symbol:	MBD1 ( CXXC3,PCM1,RFT )
Gene Full Name:	methyl-CpG binding domain protein 1
Band:	18q21.1
Quick Links	Entrez ID:4152; OMIM: 156535; Uniprot ID:MBD1_HUMAN; ENSEMBL ID: ENSG00000141644; HGNC ID: 6916
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000790	IEA	-	nuclear chromatin	-
GO:0005634	NAS	-	nucleus	10454587
GO:0005737	IEA	-	cytoplasm	-
GO:0016363	ISS	-	nuclear matrix	-
GO:0016607	ISS	-	nuclear speck	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003677	TAS	-	DNA binding	9774669
GO:0003682	IEA	-	chromatin binding	-
GO:0005515	IPI	-	protein binding	12665582
GO:0008270	IEA	-	zinc ion binding	-
GO:0008327	IDA	-	methyl-CpG binding	25284789
GO:0008327	NAS	-	methyl-CpG binding	10454587
GO:0010385	IDA	-	double-stranded methylated DNA binding	11371345

GO ID	Evidence	Qualifier	GO_term	References
GO:0006366	TAS	-	transcription from RNA polymerase II promoter	9774669
GO:0007507	IEA	-	heart development	-
GO:0007568	IEA	-	aging	-
GO:0030182	IEA	-	neuron differentiation	-
GO:0031667	IEA	-	response to nutrient levels	-
GO:0032355	IEA	-	response to estradiol	-
GO:0042220	IEA	-	response to cocaine	-
GO:0042493	IEA	-	response to drug	-
GO:0044030	IEA	-	regulation of DNA methylation	-
GO:0045892	NAS	-	negative regulation of transcription, DNA-templated	10454587
GO:0048712	IEA	-	negative regulation of astrocyte differentiation	-

Gene Symbol	Interactant	Interaction ID	References	Description
ATF7IP	MBD1	120849	12665582 15691849 16757475	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ATF7IP	MBD1	110322	12665582 15691849 16757475	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CBX5	MBD1	117030	12697822 12711603	Affinity Capture-Western; Co-localization; Reconstituted Complex
CBX5	MBD1	110322	12697822 12711603	Affinity Capture-Western; Co-localization; Reconstituted Complex
CHAF1A	MBD1	110322	12697822 15327775 17066076	Affinity Capture-Western; Two-hybrid
CHAF1A	MBD1	115349	12697822 15327775 17066076	Affinity Capture-Western; Two-hybrid
SUV39H1	MBD1	110322	12711603	Affinity Capture-Western; Co-localization; Reconstituted Complex
SUV39H1	MBD1	112706	12711603	Affinity Capture-Western; Co-localization; Reconstituted Complex
PCNA	MBD1	110322	15327775	Affinity Capture-Western
PCNA	MBD1	111142	15327775	Affinity Capture-Western
HIST1H3A	MBD1	110322	15327775	Affinity Capture-Western
HIST1H3A	MBD1	113946	15327775	Affinity Capture-Western
SETDB1	MBD1	115202	15327775 17066076	Affinity Capture-Western; Two-hybrid
SETDB1	MBD1	110322	15327775 17066076	Affinity Capture-Western; Two-hybrid
ATF7IP2	MBD1	110322	15691849	Reconstituted Complex
ATF7IP2	MBD1	123097	15691849	Reconstituted Complex
PRAM1	MBD1	110322	16432238	Affinity Capture-Western
PRAM1	MBD1	123894	16432238	Affinity Capture-Western
HDAC3	MBD1	110322	16432238	Affinity Capture-Western
HDAC3	MBD1	114368	16432238	Affinity Capture-Western
PIAS1	MBD1	110322	17066076 19074829	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS1	MBD1	114124	17066076 19074829	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS2	MBD1	110322	17066076	Reconstituted Complex; Two-hybrid
PIAS2	MBD1	114523	17066076	Reconstituted Complex; Two-hybrid
RNF2	MBD1	110322	17428788	Affinity Capture-Western; Reconstituted Complex
RNF2	MBD1	111972	17428788	Affinity Capture-Western; Reconstituted Complex
CBX4	MBD1	110322	17428788	Affinity Capture-Western; Reconstituted Complex
CBX4	MBD1	114105	17428788	Affinity Capture-Western; Reconstituted Complex
STAT1	MBD1	110322	19074829	Affinity Capture-Western
STAT1	MBD1	112649	19074829	Affinity Capture-Western
ZNF512B	MBD1	110322	20211142	Two-hybrid
ZNF512B	MBD1	121543	20211142	Two-hybrid

AutismKB 2.0

Annotation Details for MBD1

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics