AutismKB 2.0

Annotation Details for MC1R


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Basic Information Top
Gene Symbol:MC1R ( CMM5,MGC14337,MSH-R,SHEP2 )
Gene Full Name: melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Band: 16q24.3
Quick LinksEntrez ID:4157; OMIM: 155555; Uniprot ID:MSHR_HUMAN; ENSEMBL ID: ENSG00000258947; HGNC ID: 6929
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IEA-intracellular-
GO:0005886IDA-plasma membrane19452503
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane9571181
GO ID Evidence Qualifier GO_term References
GO:0004977TAS-melanocortin receptor activity9571181
GO:0004980IPI-melanocyte-stimulating hormone receptor activity19743876
GO:0005515IPI-protein binding19329486
GO:0008528TAS-G-protein coupled peptide receptor activity18292087
GO:0031625IPI-ubiquitin protein ligase binding19737927
GO ID Evidence Qualifier GO_term References
GO:0007187TAS-G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger9571181
GO:0007275TAS-multicellular organism development7581459
GO:0009650TAS-UV protection7581459
GO:0010739ISS-positive regulation of protein kinase A signaling18292087
GO:0019233IEA-sensory perception of pain-
GO:0030819IDA-positive regulation of cAMP biosynthetic process19329486
GO:0032720IMP-negative regulation of tumor necrosis factor production10233018
GO:0035556ISS-intracellular signal transduction18292087
GO:0042438IEA-melanin biosynthetic process-
GO:0043473TAS-pigmentation18292087
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter18292087
GO:0051897ISS-positive regulation of protein kinase B signaling18292087
GO:0070914IDA-UV-damage excision repair18292087
GO:0090037ISS-positive regulation of protein kinase C signaling18292087
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
POMCMC1R1103279058374 Reconstituted Complex
POMCMC1R1114399058374 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
MC1Rrs1805007 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:99456
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030502-1'