AutismKB 2.0

Annotation Details for MCL1


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Basic Information Top
Gene Symbol:MCL1 ( BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S,MGC104264,MGC1839,Mcl-1,TM,bcl2-L-3,mcl1/EAT )
Gene Full Name: myeloid cell leukemia sequence 1 (BCL2-related)
Band: 1q21.2
Quick LinksEntrez ID:4170; OMIM: 159552; Uniprot ID:MCL1_HUMAN; ENSEMBL ID: ENSG00000143384; HGNC ID: 6943
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus20467439
GO:0005654IEA-nucleoplasm-
GO:0005737TAS-cytoplasm10837489
GO:0005739IDA-mitochondrion7896880
GO:0005741TAS-mitochondrial outer membrane10837489
GO:0005759IEA-mitochondrial matrix-
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane7896880
GO:0016020ISS-membrane-
GO:0016021IEA-integral component of membrane-
GO:0097136IDA-Bcl-2 family protein complex21199865
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding15901672
GO:0015266TAS-protein channel activity10837489
GO:0046982IPI-protein heterodimerization activity10837489
GO:0051434IPI-BH3 domain binding21036904
GO ID Evidence Qualifier GO_term References
GO:0001709NAS-cell fate determination10837489
GO:0007275IEA-multicellular organism development-
GO:0008630IEA-intrinsic apoptotic signaling pathway in response to DNA damage-
GO:0008637IEA-apoptotic mitochondrial changes-
GO:0010507IMP-negative regulation of autophagy24113155
GO:0019725NAS-cellular homeostasis10837489
GO:0034097IDA-response to cytokine9184696
GO:0043066IDA-negative regulation of apoptotic process20041405
GO:0071806IEA-protein transmembrane transport-
GO:0097192IMP-extrinsic apoptotic signaling pathway in absence of ligand16543145
GO:1903378IGI-positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway23858059
GO:2000811IMP-negative regulation of anoikis22277751
GO:2001020IMP-regulation of response to DNA damage stimulus20467439
GO:2001240IMP-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand20921992
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MCL1BAD10704811483855 15694340 Protein-peptide; Reconstituted Complex; Two-hybrid
MCL1BAD11033811483855 15694340 Protein-peptide; Reconstituted Complex; Two-hybrid
MCL1BAK110705410837489 15077116 15637055 15901672 Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
MCL1BAK111033810837489 15077116 15637055 15901672 Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
MCL1BAX10705710837489 Two-hybrid
MCL1BAX11033810837489 Two-hybrid
MCL1BCL2L110707010837489 Affinity Capture-Western
MCL1BCL2L111033810837489 Affinity Capture-Western
MCL1BID10710615637055 15694340 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
MCL1BID11033815637055 15694340 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
MCL1BIK10710715694340 Protein-peptide
MCL1BIK11033815694340 Protein-peptide
MCL1BOK1071349356461 Two-hybrid
MCL1BOK1103389356461 Two-hybrid
MCL1CASP310728615637055 Biochemical Activity
MCL1CASP311033815637055 Biochemical Activity
MCL1DAD110797310965038 Affinity Capture-Western; Two-hybrid
MCL1DAD111033810965038 Affinity Capture-Western; Two-hybrid
BCL2L11MCL11103389731710 10837489 15694340 Affinity Capture-Western; Two-hybrid
BCL2L11MCL11153359731710 10837489 15694340 Affinity Capture-Western; Two-hybrid
MCL1MCL111033810837489 Affinity Capture-Western; Two-hybrid
PCNAMCL111114210978339 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PCNAMCL111033810978339 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNKSMCL111420712475993 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNKSMCL111033812475993 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VDAC1MCL111325915637055 Reconstituted Complex
VDAC1MCL111033815637055 Reconstituted Complex
BBC3MCL111800915694340 Affinity Capture-Western
BBC3MCL111033815694340 Affinity Capture-Western
PMAIP1MCL111137915694340 15901672 Affinity Capture-Western
PMAIP1MCL111033815694340 15901672 Affinity Capture-Western
HRKMCL111427615694340 Protein-peptide
HRKMCL111033815694340 Protein-peptide
BMFMCL112471615694340 Protein-peptide
BMFMCL111033815694340 Protein-peptide
UBCMCL111316416109713 17670986 Affinity Capture-Western
UBCMCL111033816109713 17670986 Affinity Capture-Western
HUWE1MCL111538516213503 Affinity Capture-Western; Biochemical Activity
HUWE1MCL111033816213503 Affinity Capture-Western; Biochemical Activity
PIN1MCL111131717670986 Affinity Capture-Western; Reconstituted Complex
PIN1MCL111033817670986 Affinity Capture-Western; Reconstituted Complex
MAPK10MCL111033817670986 Biochemical Activity
MAPK10MCL111158817670986 Biochemical Activity
Gene Symbol Interactant Interaction ID References Description
BMFMCL121604715721256 Mcl-1 interacts with Bmf. This interaction was modelled on a demonstrated interaction between Mcl-1 from an unspecified species and human Bmf.
BBC3MCL121604815721256 Mcl-1 interacts with Puma. This interaction was modelled on a demonstrated interaction between Mcl-1 from an unspecified species and human Puma.
HUWE1MCL131536815989957 Mule interacts with and ubiquitinates Mcl-1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:101769
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000511-7'