AutismKB 2.0

Annotation Details for MDM2


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Basic Information Top
Gene Symbol:MDM2 ( HDMX,MGC5370,MGC71221,hdm2 )
Gene Full Name: Mdm2 p53 binding protein homolog (mouse)
Band: 12q15
Quick LinksEntrez ID:4193; OMIM: 164785; Uniprot ID:MDM2_HUMAN; ENSEMBL ID: ENSG00000135679; HGNC ID: 6973
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10360174
GO:0005634IMP-nucleus15314173
GO:0005654IDA-nucleoplasm10707090
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus10707090
GO:0005730IMP-nucleolus11718560
GO:0005737IMP-cytoplasm15314173
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0016604IDAcolocalizes_withnuclear body10360174
GO:0030666TAS-endocytic vesicle membrane-
GO:0043234IDA-protein complex9529249
GO:0043234IMP-protein complex11718560
GO:0045202IEA-synapse-
GO ID Evidence Qualifier GO_term References
GO:0002039IPI-p53 binding9529249
GO:0004842IDA-ubiquitin-protein transferase activity9450543
GO:0004842IMP-ubiquitin-protein transferase activity20173098
GO:0005515IPI-protein binding8875929
GO:0008270IDA-zinc ion binding10722742
GO:0016874IDA-ligase activity17142452
GO:0019789EXP-SUMO transferase activity21900752
GO:0019899IPI-enzyme binding15577914
GO:0031625IPI-ubiquitin protein ligase binding18382127
GO:0042802IPI-identical protein binding17159902
GO:0042975IEA-peroxisome proliferator activated receptor binding-
GO:0047485IPI-protein N-terminus binding11718560
GO:0061630IDA-ubiquitin protein ligase activity15314173
GO:0061630IMP-ubiquitin protein ligase activity18560357
GO:0061630TAS-ubiquitin protein ligase activity-
GO:0061663IMP-NEDD8 ligase activity18560357
GO:0097110IEA-scaffold protein binding-
GO:0097718IPI-disordered domain specific binding12630860
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter9271120
GO:0001568IEA-blood vessel development-
GO:0001974IEA-blood vessel remodeling-
GO:0002027IEA-regulation of heart rate-
GO:0003181IEA-atrioventricular valve morphogenesis-
GO:0003203IEA-endocardial cushion morphogenesis-
GO:0003281IEA-ventricular septum development-
GO:0003283IEA-atrial septum development-
GO:0006461IDA-protein complex assembly10608892
GO:0006977IMP-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest21726810
GO:0006977TAS-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-
GO:0007089IEA-traversing start control point of mitotic cell cycle-
GO:0008284TAS-positive regulation of cell proliferation7791904
GO:0009636IEA-response to toxic substance-
GO:0010039IEA-response to iron ion-
GO:0010628IEA-positive regulation of gene expression-
GO:0010955IEA-negative regulation of protein processing-
GO:0010977IEA-negative regulation of neuron projection development-
GO:0016032IEA-viral process-
GO:0016567IDA-protein ubiquitination9450543
GO:0016579TAS-protein deubiquitination-
GO:0016925IEA-protein sumoylation-
GO:0018205IMP-peptidyl-lysine modification19372219
GO:0031648IDA-protein destabilization9529249
GO:0031648IMP-protein destabilization18560357
GO:0032026IEA-response to magnesium ion-
GO:0032436IDA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process11278372
GO:0034504IDA-protein localization to nucleus10360174
GO:0036369TAS-transcription factor catabolic process20181722
GO:0042176IDA-regulation of protein catabolic process9153395
GO:0042220IEA-response to cocaine-
GO:0042493IEA-response to drug-
GO:0042787IDA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process11278372
GO:0042787IGI-protein ubiquitination involved in ubiquitin-dependent protein catabolic process17237821
GO:0042787IMP-protein ubiquitination involved in ubiquitin-dependent protein catabolic process18560357
GO:0043154IEA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043278IEA-response to morphine-
GO:0043518IDA-negative regulation of DNA damage response, signal transduction by p53 class mediator9529249
GO:0045184IDA-establishment of protein localization10360174
GO:0045472IEA-response to ether-
GO:0045892IDA-negative regulation of transcription, DNA-templated9271120
GO:0045892IMP-negative regulation of transcription, DNA-templated25417702
GO:0045931IMP-positive regulation of mitotic cell cycle17290220
GO:0046677IEP-response to antibiotic20810912
GO:0046827IEA-positive regulation of protein export from nucleus-
GO:0048545IEA-response to steroid hormone-
GO:0051603IMP-proteolysis involved in cellular protein catabolic process25417702
GO:0051865IMP-protein autoubiquitination17237821
GO:0060411IEA-cardiac septum morphogenesis-
GO:0070301IEA-cellular response to hydrogen peroxide-
GO:0071157IDA-negative regulation of cell cycle arrest9529249
GO:0071301IEA-cellular response to vitamin B1-
GO:0071312IEA-cellular response to alkaloid-
GO:0071363IEA-cellular response to growth factor stimulus-
GO:0071375IEA-cellular response to peptide hormone stimulus-
GO:0071391IEA-cellular response to estrogen stimulus-
GO:0071456IEP-cellular response to hypoxia20810912
GO:0071480IDA-cellular response to gamma radiation16213212
GO:0071494IEA-cellular response to UV-C-
GO:0072717IDA-cellular response to actinomycin D15314173
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:1901797IDA-negative regulation of signal transduction by p53 class mediator16173922
GO:1902254IMP-negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator17310983
GO:1904404IEA-response to formaldehyde-
GO:1904707IEA-positive regulation of vascular smooth muscle cell proliferation-
GO:1904754IEA-positive regulation of vascular associated smooth muscle cell migration-
GO:1990000IMP-amyloid fibril formation12630860
GO:1990785IEA-response to water-immersion restraint stress-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MDM2ABL110654312110584 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MDM2ABL111035812110584 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MDM2AKT110671011715018 11923280 12145204 Affinity Capture-Western; Biochemical Activity
MDM2AKT111035811715018 11923280 12145204 Affinity Capture-Western; Biochemical Activity
MDM2AR11035815640443 17974989 Affinity Capture-Western; Co-localization
MDM2AR10686215640443 17974989 Affinity Capture-Western; Co-localization
MDM2ARRB111035812538596 18544533 Affinity Capture-Western
MDM2ARRB110690112538596 18544533 Affinity Capture-Western
MDM2ARRB210690212488444 12538596 18544533 Affinity Capture-Western
MDM2ARRB211035812488444 12538596 18544533 Affinity Capture-Western
MDM2ATF310695715933712 Reconstituted Complex
MDM2ATF311035815933712 Reconstituted Complex
MDM2CA1111035818382127 Affinity Capture-Western
MDM2CCNG111035812556559 Affinity Capture-Western; Reconstituted Complex
MDM2CCNG110734012556559 Affinity Capture-Western; Reconstituted Complex
MDM2CDH111035816980628 Affinity Capture-Western; Reconstituted Complex
MDM2CDH110743416980628 Affinity Capture-Western; Reconstituted Complex
MDM2CDKN1A11035814761977 Affinity Capture-Western; Reconstituted Complex
MDM2CDKN1A10746014761977 Affinity Capture-Western; Reconstituted Complex
MDM2CDKN2A1103589529248 9529249 12085228 14612427 16107876 18583933 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MDM2CDKN2A1074639529248 9529249 12085228 14612427 16107876 18583933 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MDM2CTBP111035812867035 Affinity Capture-Western; Far Western
MDM2CTBP110786912867035 Affinity Capture-Western; Far Western
MDM2CTBP210787012867035 Affinity Capture-Western; Reconstituted Complex
MDM2CTBP211035812867035 Affinity Capture-Western; Reconstituted Complex
MDM2DAXX10798518583933 Affinity Capture-Western
MDM2DAXX11035818583933 Affinity Capture-Western
MDM2DHFR10806518451149 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MDM2DHFR11035818451149 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MDM2E2F110820116170383 Affinity Capture-Western
MDM2E2F111035816170383 Affinity Capture-Western
MDM2EP3001083479809062 15154850 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
MDM2EP3001103589809062 15154850 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
MDM2ESR110840310766163 Reconstituted Complex
MDM2ESR111035810766163 Reconstituted Complex
MDM2FKBP310857719166840 Affinity Capture-Western; Reconstituted Complex
MDM2FKBP311035819166840 Affinity Capture-Western; Reconstituted Complex
MDM2GATA310889515975924 Affinity Capture-Western
MDM2GATA311035815975924 Affinity Capture-Western
MDM2GNAS10904018948082 Affinity Capture-Western
MDM2GNAS11035818948082 Affinity Capture-Western
MDM2SFN11035817546054 Affinity Capture-Western; Reconstituted Complex
MDM2SFN10907217546054 Affinity Capture-Western; Reconstituted Complex
MDM2NR3C111035811562347 Affinity Capture-Western
MDM2NR3C110916511562347 Affinity Capture-Western
MDM2GTF2E11092159271120 Reconstituted Complex
MDM2GTF2E11103589271120 Reconstituted Complex
MDM2HDAC110931512426395 15640443 Affinity Capture-Western; Co-localization; Reconstituted Complex
MDM2HDAC111035812426395 15640443 Affinity Capture-Western; Co-localization; Reconstituted Complex
MDM2HIF1A10933810640274 12606552 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MDM2HIF1A11035810640274 12606552 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MDM2IGF1R10970112821780 18632619 Affinity Capture-Western; Biochemical Activity
MDM2IGF1R11035812821780 18632619 Affinity Capture-Western; Biochemical Activity
TP53MDM21130107686617 9271120 9529249 9809062 10722742 10766163 11384992 11431470 11562347 11709713 11713288 11744695 11925449 12167711 12208736 12426395 12612087 12620407 12915590 12944468 14596917 14612427 14671306 14702041 15064742 15122315 15154850 15210108 15295102 15308643 15542844 15908921 15933712 16023600 16107876 16547496 16579792 16624812 16857591 16866370 16964247 17098746 17139261 17363365 17369817 17380154 17470788 17525743 17591690 17908790 17936559 18172499 18223694 18309296 18332869 18485870 18665269 19071110 19085961 19098711 19166840 19188367 19223463 19303885 21454483 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation; Co-localization; PCA; Reconstituted Complex
TP53MDM21103587686617 9271120 9529249 9809062 10722742 10766163 11384992 11431470 11562347 11709713 11713288 11744695 11925449 12167711 12208736 12426395 12612087 12620407 12915590 12944468 14596917 14612427 14671306 14702041 15064742 15122315 15154850 15210108 15295102 15308643 15542844 15908921 15933712 16023600 16107876 16547496 16579792 16624812 16857591 16866370 16964247 17098746 17139261 17363365 17369817 17380154 17470788 17525743 17591690 17908790 17936559 18172499 18223694 18309296 18332869 18485870 18665269 19071110 19085961 19098711 19166840 19188367 19223463 19303885 21454483 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation; Co-localization; PCA; Reconstituted Complex
RPL5MDM21120457935455 14612427 15308643 15314173 18426907 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RPL5MDM21103587935455 14612427 15308643 15314173 18426907 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
TBPMDM21103589271120 9388200 Reconstituted Complex
TBPMDM21127719271120 9388200 Reconstituted Complex
TAF1MDM21127359388200 Reconstituted Complex
TAF1MDM21103589388200 Reconstituted Complex
RB1MDM211186010078201 15044952 Affinity Capture-Western; Reconstituted Complex
RB1MDM211035810078201 15044952 Affinity Capture-Western; Reconstituted Complex
TP73MDM211301410207051 10435614 Affinity Capture-Western; Reconstituted Complex
TP73MDM211035810207051 10435614 Affinity Capture-Western; Reconstituted Complex
MDM4MDM211035910218570 12393902 12483531 12860999 16227609 18219319 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MDM4MDM211035810218570 12393902 12483531 12860999 16227609 18219319 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MDM2MDM211035810722742 14596917 16714300 16803902 16965791 17936559 19166840 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex
MTBPMDM211798810906133 15632057 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
MTBPMDM211035810906133 15632057 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
EID1MDM211724311073989 Affinity Capture-Western
EID1MDM211035811073989 Affinity Capture-Western
TSG101MDM211310211172000 Affinity Capture-Western
TSG101MDM211035811172000 Affinity Capture-Western
SUMO1MDM211318811384992 12917636 15876864 18583933 Affinity Capture-Western
SUMO1MDM211035811384992 12917636 15876864 18583933 Affinity Capture-Western
UBE2IMDM211317711384992 Affinity Capture-Western; Reconstituted Complex
UBE2IMDM211035811384992 Affinity Capture-Western; Reconstituted Complex
KAT5MDM211035811927554 19150978 Affinity Capture-Western; Reconstituted Complex
KAT5MDM211577911927554 19150978 Affinity Capture-Western; Reconstituted Complex
KAT2BMDM211437512068014 14769800 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex
KAT2BMDM211035812068014 14769800 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex
UBCMDM211035812145204 12167711 15314155 15632057 16023600 16227609 16479015 17353187 17879958 17936559 18382127 18566590 18583933 Affinity Capture-Western; Reconstituted Complex
UBCMDM211316412145204 12167711 15314155 15632057 16023600 16227609 16479015 17353187 17879958 17936559 18382127 18566590 18583933 Affinity Capture-Western; Reconstituted Complex
UBE2AMDM211316712640129 Affinity Capture-Western
UBE2AMDM211035812640129 Affinity Capture-Western
NUMBMDM211420212646252 18172499 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NUMBMDM211035812646252 18172499 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PMLMDM211138412759344 12915590 14507915 15195100 19150978 Affinity Capture-Western; Reconstituted Complex
PMLMDM211035812759344 12915590 14507915 15195100 19150978 Affinity Capture-Western; Reconstituted Complex
MDC1MDM211501414578343 Protein-peptide
MDC1MDM211035814578343 Protein-peptide
RPL11MDM211205514612427 15308643 15314173 16803902 18426907 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RPL11MDM211035814612427 15308643 15314173 16803902 18426907 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RAD23AMDM211182315064742 Affinity Capture-Western; Reconstituted Complex
RAD23AMDM211035815064742 Affinity Capture-Western; Reconstituted Complex
YY1MDM211336015210108 Affinity Capture-Western; Reconstituted Complex
YY1MDM211035815210108 Affinity Capture-Western; Reconstituted Complex
RPL23MDM211475215308643 15314173 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RPL23MDM211035815308643 15314173 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
HIST2H2BEMDM211394515546622 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HIST2H2BEMDM211035815546622 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PSMD10MDM211168816023600 17904523 18332869 Affinity Capture-Western; Reconstituted Complex
PSMD10MDM211035816023600 17904523 18332869 Affinity Capture-Western; Reconstituted Complex
TRIM28MDM211545716107876 Affinity Capture-MS; Affinity Capture-Western
TRIM28MDM211035816107876 Affinity Capture-MS; Affinity Capture-Western
USP7MDM211362216402859 16943424 17380154 17936559 Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Protein-peptide
USP7MDM211035816402859 16943424 17380154 17936559 Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Protein-peptide
PYHIN1MDM212722516479015 Affinity Capture-Western
PYHIN1MDM211035816479015 Affinity Capture-Western
NCLMDM211077116751805 Affinity Capture-Western; Reconstituted Complex
NCLMDM211035816751805 Affinity Capture-Western; Reconstituted Complex
YWHAQMDM211616816943424 Affinity Capture-Western
YWHAQMDM211035816943424 Affinity Capture-Western
CHEK2MDM211636916943424 Biochemical Activity
CHEK2MDM211035816943424 Biochemical Activity
DDX17MDM211577617226766 Affinity Capture-Luminescence
DDX17MDM211035817226766 Affinity Capture-Luminescence
RBBP6MDM211186517470788 Affinity Capture-Western
RBBP6MDM211035817470788 Affinity Capture-Western
COPS5MDM211618317879958 Affinity Capture-Western; Reconstituted Complex
COPS5MDM211035817879958 Affinity Capture-Western; Reconstituted Complex
PPM1DMDM211406517936559 Affinity Capture-Western
PPM1DMDM211035817936559 Affinity Capture-Western
PTK2MDM211171918206965 Reconstituted Complex
PTK2MDM211035818206965 Reconstituted Complex
PSME3MDM211549218309296 Affinity Capture-Western; Reconstituted Complex
PSME3MDM211035818309296 Affinity Capture-Western; Reconstituted Complex
CCAR1MDM211035818382127 Affinity Capture-Western
GNL3MDM211769018426907 Affinity Capture-Western; Reconstituted Complex
GNL3MDM211035818426907 Affinity Capture-Western; Reconstituted Complex
FOXO4MDM211044918665269 Affinity Capture-Western; Biochemical Activity
FOXO4MDM211035818665269 Affinity Capture-Western; Biochemical Activity
RPL26MDM211207318951086 Affinity Capture-Western; Biochemical Activity
RPL26MDM211035818951086 Affinity Capture-Western; Biochemical Activity
RRM2BMDM211907119015526 Affinity Capture-Western; Biochemical Activity
RRM2BMDM211035819015526 Affinity Capture-Western; Biochemical Activity
RYBPMDM211035819098711 Affinity Capture-Western; Reconstituted Complex
RYBPMDM211699719098711 Affinity Capture-Western; Reconstituted Complex
BANPMDM211035819303885 Affinity Capture-Western; Reconstituted Complex
BANPMDM212030819303885 Affinity Capture-Western; Reconstituted Complex
UBE2UMDM212715619690564 Two-hybrid
UBE2UMDM211035819690564 Two-hybrid
UBE2ZMDM212241919690564 Two-hybrid
UBE2ZMDM211035819690564 Two-hybrid
UBE2G2MDM211317519690564 Two-hybrid
UBE2G2MDM211035819690564 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
RB1MDM219721515577944 Rb interacts with Mdm2.
TP53MDM22956199223638 hdm2 interacts with p53. This interaction was modeled on a demonstrated interaction between hdm2 and p53 both from an unspecified species.
TP53MDM229593210781812 p53 interacts with mdm2. This interaction was modelled on a demonstrated interaction between human p53 and mdm2 from an unspecified species.
TP53MDM230091511597128 p53 interacts with Mdm2.
TP53MDM229536515280377 Mdm2 interacts with and ubiquitinates p53.
TP53MDM219385515558054 HDM-2 interacts with p53
TP53MDM219308115577914 p53 interacts with and is ubiquitinated by Mdm2.
TP53MDM219732915577944 p53 interacts with Mdm2.
TP53MDM221980415688025 MDM2 (HDM2) interacts with TP53 (p53). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human TP53.
TP53MDM229558715824742 p53 interacts with unspecified isoform of Mdm2.
TP53MDM229516515867431 An unspecifed isoform of Mdm2 interacts with p53.
TP53MDM230061315950904 An unspecified isoform of HDM2 interacts with p53. This interaction was modelled on a demonstrated interaction between human HDM2 and p53 from an unspecified species.
HIST3H3MDM218381815546622 Mdm2 interacts with H3.
MAPKAPK2MDM221976415688025 MDM2 (HDM2) interacts with MAPKAPK2 isoform 1 (MK2). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2.
RBL2MDM219732715577944 p130 interacts with Mdm2.
MAPKAPK2MDM222552615688025 MDM2 (HDM2) interacts with MAPKAPK2 (MK2) isoform 2. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2.
HIST4H4MDM218381915546622 Mdm2 interacts with H4.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96952
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-153'