AutismKB 2.0

Annotation Details for MECP2


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Basic Information Top
Gene Symbol:MECP2 ( AUTSX3,DKFZp686A24160,MRX16,MRX79,MRXS13,MRXSL,PPMX,RS,RTS,RTT )
Gene Full Name: methyl CpG binding protein 2 (Rett syndrome)
Band: Xq28
Quick LinksEntrez ID:4204; OMIM: 300005; Uniprot ID:MECP2_HUMAN; ENSEMBL ID: ENSG00000169057; HGNC ID: 6990
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000792IDA-heterochromatin11441023
GO:0000930IMPcolocalizes_withgamma-tubulin complex25527496
GO:0005615IDA-extracellular space22664934
GO:0005634IDA-nucleus11441023
GO:0005739IEA-mitochondrion-
GO:0005813IMPcolocalizes_withcentrosome25527496
GO:0005829IEA-cytosol-
GO:0098794IEA-postsynapse-
GO ID Evidence Qualifier GO_term References
GO:0001078IEA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003677TAS-DNA binding9620804
GO:0003682IEA-chromatin binding-
GO:0003714TAS-transcription corepressor activity10773092
GO:0003723IDA-RNA binding22658674
GO:0003729IEA-mRNA binding-
GO:0005515IPI-protein binding15696166
GO:0008134IEA-transcription factor binding-
GO:0008327IEA-methyl-CpG binding-
GO:0010385IMP-double-stranded methylated DNA binding17296936
GO:0019904IPI-protein domain specific binding11441023
GO:0035197IEA-siRNA binding-
GO:0047485IPI-protein N-terminus binding11441023
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter9620804
GO:0001662IEA-behavioral fear response-
GO:0001666IEA-response to hypoxia-
GO:0001964IEA-startle response-
GO:0001976IEA-neurological system process involved in regulation of systemic arterial blood pressure-
GO:0002087IEA-regulation of respiratory gaseous exchange by neurological system process-
GO:0006020IEA-inositol metabolic process-
GO:0006122IEA-mitochondrial electron transport, ubiquinol to cytochrome c-
GO:0006342IEA-chromatin silencing-
GO:0006349IEA-regulation of gene expression by genetic imprinting-
GO:0006351IEA-transcription, DNA-templated-
GO:0006541IEA-glutamine metabolic process-
GO:0006576IEA-cellular biogenic amine metabolic process-
GO:0007052IMP-mitotic spindle organization25527496
GO:0007416IEA-synapse assembly-
GO:0007585IEA-respiratory gaseous exchange-
GO:0007616IEA-long-term memory-
GO:0008104IEA-protein localization-
GO:0008211IEA-glucocorticoid metabolic process-
GO:0008284IMP-positive regulation of cell proliferation25527496
GO:0008344IEA-adult locomotory behavior-
GO:0008542IEA-visual learning-
GO:0009405IEA-pathogenesis-
GO:0009791IEA-post-embryonic development-
GO:0010971IMP-positive regulation of G2/M transition of mitotic cell cycle25527496
GO:0016358IEA-dendrite development-
GO:0016571IEA-histone methylation-
GO:0016573IEA-histone acetylation-
GO:0019230IEA-proprioception-
GO:0019233IEA-sensory perception of pain-
GO:0021549IEA-cerebellum development-
GO:0021591IEA-ventricular system development-
GO:0031061IEA-negative regulation of histone methylation-
GO:0032048IEA-cardiolipin metabolic process-
GO:0035067IEA-negative regulation of histone acetylation-
GO:0035176IEA-social behavior-
GO:0042551IEA-neuron maturation-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045892IDA-negative regulation of transcription, DNA-templated11441023
GO:0045893IEA-positive regulation of transcription, DNA-templated-
GO:0046470IEA-phosphatidylcholine metabolic process-
GO:0050432IEA-catecholamine secretion-
GO:0051151IEA-negative regulation of smooth muscle cell differentiation-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0060291IEA-long-term synaptic potentiation-
GO:0090063IMP-positive regulation of microtubule nucleation25527496
GO:1900114IEA-positive regulation of histone H3-K9 trimethylation-
GO:2000820IEA-negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MECP2DNMT110812312473678 Affinity Capture-Western; Reconstituted Complex
MECP2DNMT111036812473678 Affinity Capture-Western; Reconstituted Complex
MECP2GTF2B10921410756192 Reconstituted Complex
MECP2GTF2B11036810756192 Reconstituted Complex
MECP2HDAC110931512473678 14593184 14647463 16331260 Affinity Capture-Western; Reconstituted Complex
MECP2HDAC111036812473678 14593184 14647463 16331260 Affinity Capture-Western; Reconstituted Complex
MECP2HMGB111036811748221 Reconstituted Complex
MECP2HMGB110938911748221 Reconstituted Complex
MECP2RBPJ10973616763620 Affinity Capture-Western
MECP2RBPJ11036816763620 Affinity Capture-Western
MECP2LBR11012219331822 Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
MECP2LBR11036819331822 Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
PRPF40AMECP21103689171351 14618241 Affinity Capture-Western; Far Western; Reconstituted Complex
PRPF40AMECP21207929171351 14618241 Affinity Capture-Western; Far Western; Reconstituted Complex
SIN3BMECP21169019620779 Affinity Capture-Western
SIN3BMECP21103689620779 Affinity Capture-Western
SIN3AMECP21174399620779 9620804 10773092 14593184 15322089 Affinity Capture-Western; Reconstituted Complex
SIN3AMECP21103689620779 9620804 10773092 14593184 15322089 Affinity Capture-Western; Reconstituted Complex
SKIMECP211036811441023 Affinity Capture-Western; Reconstituted Complex
SKIMECP211238811441023 Affinity Capture-Western; Reconstituted Complex
NCOR1MECP211497311441023 Reconstituted Complex
NCOR1MECP211036811441023 Reconstituted Complex
RCOR1MECP211679612399542 Affinity Capture-Western
RCOR1MECP211036812399542 Affinity Capture-Western
SUV39H1MECP211270612399542 Affinity Capture-Western
SUV39H1MECP211036812399542 Affinity Capture-Western
HIST2H3AMECP213061612427740 Reconstituted Complex
HIST2H3AMECP211036812427740 Reconstituted Complex
PRPF40BMECP211730514618241 Affinity Capture-Western; Reconstituted Complex
PRPF40BMECP211036814618241 Affinity Capture-Western; Reconstituted Complex
SPI1MECP211036814647463 16331260 Affinity Capture-Western; Reconstituted Complex
SPI1MECP211256614647463 16331260 Affinity Capture-Western; Reconstituted Complex
SP1MECP211036815109260 Affinity Capture-Western
SP1MECP211255015109260 Affinity Capture-Western
SMARCE1MECP211248915696166 Affinity Capture-Western
SMARCE1MECP211036815696166 Affinity Capture-Western
SMARCA2MECP211247915696166 Affinity Capture-Western; Reconstituted Complex
SMARCA2MECP211036815696166 Affinity Capture-Western; Reconstituted Complex
SMARCB1MECP211248215696166 Reconstituted Complex
SMARCB1MECP211036815696166 Reconstituted Complex
CDKL5MECP211266815917271 Affinity Capture-Western; Reconstituted Complex
CDKL5MECP211036815917271 Affinity Capture-Western; Reconstituted Complex
YBX1MECP211036816251272 Affinity Capture-Western
YBX1MECP211095916251272 Affinity Capture-Western
CBX5MECP211703017698499 Affinity Capture-Western
CBX5MECP211036817698499 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99918
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7190'