AutismKB 2.0

Annotation Details for MEF2A


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Basic Information Top
Gene Symbol:MEF2A ( ADCAD1,RSRFC4,RSRFC9 )
Gene Full Name: myocyte enhancer factor 2A
Band: 15q26.3
Quick LinksEntrez ID:4205; OMIM: 600660; Uniprot ID:MEF2A_HUMAN; ENSEMBL ID: ENSG00000068305; HGNC ID: 6993
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790ISS-nuclear chromatin-
GO:0005634IDA-nucleus16484498
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IDA-transcription factor complex16043483
GO:0005829IDA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding20590529
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding7760790
GO:0000981IDA-RNA polymerase II transcription factor activity, sequence-specific DNA binding10748098
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding7760790
GO:0001085IPI-RNA polymerase II transcription factor binding15466416
GO:0001105IDA-RNA polymerase II transcription coactivator activity15466416
GO:0003682IDA-chromatin binding21468593
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding16043483
GO:0003705IEA-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-
GO:0005515IPI-protein binding15466416
GO:0005515IPIcontributes_toprotein binding16043483
GO:0019901IEA-protein kinase binding-
GO:0033613IPI-activating transcription factor binding20590529
GO:0035035IPI-histone acetyltransferase binding20590529
GO:0042826IPI-histone deacetylase binding10748098
GO:0043565IDA-sequence-specific DNA binding10835359
GO:0046332IPI-SMAD binding11160896
GO:0046982IPI-protein heterodimerization activity9858528
GO ID Evidence Qualifier GO_term References
GO:0000002ISS-mitochondrial genome maintenance-
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter16484498
GO:0000165IDA-MAPK cascade9858528
GO:0006351IDA-transcription, DNA-templated16043483
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006915IEA-apoptotic process-
GO:0007507IEP-heart development10458488
GO:0007517NAS-muscle organ development1516833
GO:0010613IDA-positive regulation of cardiac muscle hypertrophy24161931
GO:0010613IGI-positive regulation of cardiac muscle hypertrophy24161931
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter7760790
GO:0048311ISS-mitochondrion distribution-
GO:0048813ISS-dendrite morphogenesis-
GO:0051149TAS-positive regulation of muscle cell differentiation-
GO:0055005ISS-ventricular cardiac myofibril assembly-
GO:0061337ISS-cardiac conduction-
GO:0070375IMP-ERK5 cascade15132737
GO:0071277IDA-cellular response to calcium ion16484498
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MEF2AACTN410659616980305 Affinity Capture-Western; Reconstituted Complex
MEF2AACTN411036916980305 Affinity Capture-Western; Reconstituted Complex
MEF2AASCL11103698662987 Affinity Capture-Western; Reconstituted Complex
MEF2AASCL11069218662987 Affinity Capture-Western; Reconstituted Complex
MEF2AMAPK141078199858528 10330143 Biochemical Activity
MEF2AMAPK141103699858528 10330143 Biochemical Activity
MEF2AEP30010834712371907 Affinity Capture-Western; Reconstituted Complex
MEF2AEP30011036912371907 Affinity Capture-Western; Reconstituted Complex
MEF2ASMAD211026211160896 Affinity Capture-Western; Reconstituted Complex
MEF2ASMAD211036911160896 Affinity Capture-Western; Reconstituted Complex
MYOGMEF2A1107391329097 Reconstituted Complex
MYOGMEF2A1103691329097 Reconstituted Complex
MEF2DMEF2A1103738798771 Affinity Capture-Western; Co-localization
MEF2DMEF2A1103698798771 Affinity Capture-Western; Co-localization
MAPK7MEF2A1115849753748 Affinity Capture-Western
MAPK7MEF2A1103699753748 Affinity Capture-Western
HDAC9MEF2A11036910487761 10748098 Affinity Capture-Western; Reconstituted Complex
HDAC9MEF2A11508310487761 10748098 Affinity Capture-Western; Reconstituted Complex
HDAC4MEF2A11036910487761 10748098 19389706 Affinity Capture-Western; Reconstituted Complex
HDAC4MEF2A11510610487761 10748098 19389706 Affinity Capture-Western; Reconstituted Complex
HDAC5MEF2A11036910748098 12626519 Affinity Capture-Western; Reconstituted Complex
HDAC5MEF2A11533110748098 12626519 Affinity Capture-Western; Reconstituted Complex
THRAMEF2A11036912371907 Affinity Capture-Western; Reconstituted Complex
THRAMEF2A11292312371907 Affinity Capture-Western; Reconstituted Complex
VGLL4MEF2A11036915140898 Two-hybrid
VGLL4MEF2A11503915140898 Two-hybrid
HDAC7MEF2A11036916956611 16980305 Reconstituted Complex; Two-hybrid
HDAC7MEF2A11961316956611 16980305 Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
MEF2AMEF2A_P279L, rs3138597 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:99532
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-163'