AutismKB 2.0

Annotation Details for MAP3K1


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Basic Information Top
Gene Symbol:MAP3K1 ( MAPKKK1,MEKK,MEKK1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 1
Band: 5q11.2
Quick LinksEntrez ID:4214; OMIM: 600982; Uniprot ID:M3K1_HUMAN; ENSEMBL ID: ENSG00000095015; HGNC ID: 6848
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity15001576
GO:0004672TAS-protein kinase activity-
GO:0004674EXP-protein serine/threonine kinase activity7997270
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0004709NAS-MAP kinase kinase kinase activity9808624
GO:0005515IPI-protein binding9808624
GO:0005524IEA-ATP binding-
GO:0008270IEA-zinc ion binding-
GO:0019901IPI-protein kinase binding17906693
GO ID Evidence Qualifier GO_term References
GO:0000165IEA-MAPK cascade-
GO:0000186IEA-activation of MAPKK activity-
GO:0002755TAS-MyD88-dependent toll-like receptor signaling pathway-
GO:0006468NAS-protein phosphorylation9808624
GO:0006915IBA-apoptotic process-
GO:0030036IBA-actin cytoskeleton organization-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0071260IEP-cellular response to mechanical stimulus19593445
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K1ALK10673914968112 Affinity Capture-MS; Affinity Capture-Western
MAP3K1ALK11037814968112 Affinity Capture-MS; Affinity Capture-Western
MAP3K1DTX111037815684388 Affinity Capture-Western; Reconstituted Complex
MAP3K1DTX110817315684388 Affinity Capture-Western; Reconstituted Complex
MAP3K1DVL211037810829020 Affinity Capture-Western
MAP3K1DVL210818910829020 Affinity Capture-Western
MAP3K1FKBP511037814743216 Affinity Capture-MS
MAP3K1FKBP510857914743216 Affinity Capture-MS
MAP3K1GRB21103789733714 Affinity Capture-Western; Reconstituted Complex
MAP3K1GRB21091429733714 Affinity Capture-Western; Reconstituted Complex
MAP3K1HSP90AA211037814743216 Affinity Capture-MS
MAP3K1HSP90AA210955614743216 Affinity Capture-MS
MAP3K1IKBKB11037811057907 Biochemical Activity
MAP3K1IKBKB10976711057907 Biochemical Activity
MAP4K4MAP3K11103789135144 Affinity Capture-Western
MAP4K4MAP3K11148389135144 Affinity Capture-Western
MAPK8MAP3K11115859405400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8MAP3K11103789405400 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
YWHAEMAP3K11103789452471 Reconstituted Complex
YWHAEMAP3K11133639452471 Reconstituted Complex
UBE2IMAP3K11103789563508 Reconstituted Complex; Two-hybrid
UBE2IMAP3K11131779563508 Reconstituted Complex; Two-hybrid
MAP4K2MAP3K11103789712898 Reconstituted Complex
MAP4K2MAP3K11118099712898 Reconstituted Complex
TRAF2MAP3K111037810346818 Affinity Capture-Western; Co-fractionation
TRAF2MAP3K111303810346818 Affinity Capture-Western; Co-fractionation
MAPK8IP3MAP3K111037810523642 Affinity Capture-Western
MAPK8IP3MAP3K111677410523642 Affinity Capture-Western
MAP2K4MAP3K111037810713157 Affinity Capture-Western
MAP2K4MAP3K111231510713157 Affinity Capture-Western
AXIN1MAP3K111037810829020 11884395 Affinity Capture-Western
AXIN1MAP3K111390910829020 11884395 Affinity Capture-Western
MAPK1MAP3K111037810969079 Affinity Capture-Western
MAPK1MAP3K111158010969079 Affinity Capture-Western
MAP2K1MAP3K111037810969079 Affinity Capture-Western
MAP2K1MAP3K111159010969079 Affinity Capture-Western
RAF1MAP3K111183110969079 Affinity Capture-Western; Reconstituted Complex
RAF1MAP3K111037810969079 Affinity Capture-Western; Reconstituted Complex
DCAF7MAP3K111037814743216 Affinity Capture-MS
DCAF7MAP3K111553214743216 Affinity Capture-MS
CDC37MAP3K111037814743216 Affinity Capture-MS
CDC37MAP3K111631214743216 Affinity Capture-MS
RPL4MAP3K111037814743216 Affinity Capture-MS
RPL4MAP3K111204414743216 Affinity Capture-MS
RPL30MAP3K111037814743216 Affinity Capture-MS
RPL30MAP3K111207514743216 Affinity Capture-MS
RPS13MAP3K111037814743216 Affinity Capture-MS
RPS13MAP3K111212114743216 Affinity Capture-MS
UBCMAP3K111037815684388 Affinity Capture-Western
UBCMAP3K111316415684388 Affinity Capture-Western
UBE2D4MAP3K111037819690564 Two-hybrid
UBE2D4MAP3K111964119690564 Two-hybrid
UBE2WMAP3K111037819690564 Two-hybrid
UBE2WMAP3K112057219690564 Two-hybrid
UBE2D1MAP3K111037819690564 Two-hybrid
UBE2D1MAP3K111316919690564 Two-hybrid
UBE2D2MAP3K111037819690564 Two-hybrid
UBE2D2MAP3K111317019690564 Two-hybrid
UBE2D3MAP3K111037819690564 Two-hybrid
UBE2D3MAP3K111317119690564 Two-hybrid
UBE2E1MAP3K111037819690564 Two-hybrid
UBE2E1MAP3K111317219690564 Two-hybrid
UBE2L6MAP3K111037819690564 Two-hybrid
UBE2L6MAP3K111467219690564 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346872
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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