AutismKB 2.0

Annotation Details for MAP3K4


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Basic Information Top
Gene Symbol:MAP3K4 ( FLJ42439,KIAA0213,MAPKKK4,MEKK4,MTK1,PRO0412 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 4
Band: 6q26
Quick LinksEntrez ID:4216; OMIM: 602425; Uniprot ID:M3K4_HUMAN; ENSEMBL ID: ENSG00000085511; HGNC ID: 6856
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm9827804
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004709IDA-MAP kinase kinase kinase activity9305639
GO:0005515IPI-protein binding12052864
GO:0005524IEA-ATP binding-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000165IEA-MAPK cascade-
GO:0000186IDA-activation of MAPKK activity9305639
GO:0001890IEA-placenta development-
GO:0010225IMP-response to UV-C9305639
GO:0010468IEA-regulation of gene expression-
GO:0019100IEA-male germ-line sex determination-
GO:0030036IBA-actin cytoskeleton organization-
GO:0032212IMP-positive regulation of telomere maintenance via telomerase21531765
GO:0035556ISS-intracellular signal transduction-
GO:0043507IDA-positive regulation of JUN kinase activity9305639
GO:0051973IMP-positive regulation of telomerase activity21531765
GO:0060718IEA-chorionic trophoblast cell differentiation-
GO:1900745IDA-positive regulation of p38MAPK cascade9305639
GO:1904355IMP-positive regulation of telomere capping21531765
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K4ALK10673914968112 Affinity Capture-MS
MAP3K4ALK11038014968112 Affinity Capture-MS
MAP3K4CDC421103809079650 Reconstituted Complex
MAP3K4CDC421074339079650 Reconstituted Complex
MAP3K4GADD45A1103809827804 Affinity Capture-Western; Two-hybrid
MAP3K4GADD45A1080149827804 Affinity Capture-Western; Two-hybrid
RAC1MAP3K41103809079650 Reconstituted Complex
RAC1MAP3K41118179079650 Reconstituted Complex
GADD45GMAP3K41103809827804 Affinity Capture-Western; Two-hybrid
GADD45GMAP3K41161179827804 Affinity Capture-Western; Two-hybrid
GADD45BMAP3K41103809827804 16256071 Affinity Capture-Western; Two-hybrid
GADD45BMAP3K41107019827804 16256071 Affinity Capture-Western; Two-hybrid
MAP2K1MAP3K41103809841871 Biochemical Activity
MAP2K1MAP3K41115909841871 Biochemical Activity
MAP2K3MAP3K41103809841871 Biochemical Activity
MAP2K3MAP3K41115929841871 Biochemical Activity
MAP2K6MAP3K41103809841871 Biochemical Activity
MAP2K6MAP3K41115949841871 Biochemical Activity
MAP2K4MAP3K41103809841871 Biochemical Activity
MAP2K4MAP3K41123159841871 Biochemical Activity
UBCMAP3K411038016256071 Affinity Capture-Western
UBCMAP3K411316416256071 Affinity Capture-Western
SH3KBP1MAP3K411038016256071 Affinity Capture-Western; Reconstituted Complex
SH3KBP1MAP3K411902916256071 Affinity Capture-Western; Reconstituted Complex
CEP110MAP3K411624820936779 Two-hybrid
CEP110MAP3K411038020936779 Two-hybrid
TPRMAP3K411038020936779 Two-hybrid
TPRMAP3K411302820936779 Two-hybrid
YWHAZMAP3K411038020936779 Two-hybrid
YWHAZMAP3K411336620936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346875
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990603-4'