AutismKB 2.0

Annotation Details for MAP3K5


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Basic Information Top
Gene Symbol:MAP3K5 ( ASK1,MAPKKK5,MEKK5 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 5
Band: 6q23.3
Quick LinksEntrez ID:4217; OMIM: 602448; Uniprot ID:M3K5_HUMAN; ENSEMBL ID: ENSG00000197442; HGNC ID: 6857
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0009897IEA-external side of plasma membrane-
GO:0043234IMP-protein complex11096076
GO:1902911IDA-protein kinase complex15983381
GO:1990604IDA-IRE1-TRAF2-ASK1 complex12050113
GO ID Evidence Qualifier GO_term References
GO:0000287IDA-magnesium ion binding17210579
GO:0004672IDA-protein kinase activity11096076
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004709IDA-MAP kinase kinase kinase activity17210579
GO:0005515IPI-protein binding9743501
GO:0005524IDA-ATP binding17210579
GO:0019901IEA-protein kinase binding-
GO:0019903IPI-protein phosphatase binding11959862
GO:0019904IPI-protein domain specific binding11096076
GO:0042803IDA-protein homodimerization activity11920685
GO ID Evidence Qualifier GO_term References
GO:0000165IDA-MAPK cascade17210579
GO:0000186IDA-activation of MAPKK activity11959862
GO:0002931IEA-response to ischemia-
GO:0006468IDA-protein phosphorylation11096076
GO:0007254IDA-JNK cascade21771788
GO:0007257TAS-activation of JUN kinase activity8974401
GO:0008631IDA-intrinsic apoptotic signaling pathway in response to oxidative stress21771788
GO:0010666IEA-positive regulation of cardiac muscle cell apoptotic process-
GO:0016032IEA-viral process-
GO:0034198IDA-cellular response to amino acid starvation11096076
GO:0034976IMP-response to endoplasmic reticulum stress23000344
GO:0038066IEA-p38MAPK cascade-
GO:0042060IEA-wound healing-
GO:0043065IDA-positive regulation of apoptotic process21771788
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process20674765
GO:0043507IMP-positive regulation of JUN kinase activity23000344
GO:0045087IEA-innate immune response-
GO:0045663IEA-positive regulation of myoblast differentiation-
GO:0045893IDA-positive regulation of transcription, DNA-templated11096076
GO:0046330ISS-positive regulation of JNK cascade-
GO:0051403IDA-stress-activated MAPK cascade11096076
GO:0070059ISS-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-
GO:0070301IDA-cellular response to hydrogen peroxide20674765
GO:0071356IEA-cellular response to tumor necrosis factor-
GO:0072577IEA-endothelial cell apoptotic process-
GO:0097190TAS-apoptotic signaling pathway8974401
GO:0097300IEA-programmed necrotic cell death-
GO:1900745IEA-positive regulation of p38MAPK cascade-
GO:1901216IGI-positive regulation of neuron death15983381
GO:1901216ISS-positive regulation of neuron death-
GO:1902170IEA-cellular response to reactive nitrogen species-
GO:1904707IEA-positive regulation of vascular smooth muscle cell proliferation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K5ALK10673914968112 Affinity Capture-MS
MAP3K5ALK11038114968112 Affinity Capture-MS
MAP3K5ARRB211038111090355 Affinity Capture-Western
MAP3K5ARRB210690211090355 Affinity Capture-Western
MAP3K5CDC25A11038111416155 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP3K5CDC25A10742811416155 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP3K5CDKN1A11038112820963 Affinity Capture-Western
MAP3K5CDKN1A10746012820963 Affinity Capture-Western
MAP3K5CREBBP11038120936779 Two-hybrid
MAP3K5CREBBP10777720936779 Two-hybrid
MAP3K5DAXX1079859743501 Affinity Capture-Western
MAP3K5DAXX1103819743501 Affinity Capture-Western
MAP3K5DMD10809620936779 Two-hybrid
MAP3K5DMD11038120936779 Two-hybrid
MAP3K5EP30010834720936779 Two-hybrid
MAP3K5EP30011038120936779 Two-hybrid
MAP3K5ERN111038112050113 Affinity Capture-Western
MAP3K5ERN110839112050113 Affinity Capture-Western
MAP3K5GLRX11038112244106 Affinity Capture-Western
MAP3K5GLRX10900712244106 Affinity Capture-Western
MAP3K5GNA1210903017595347 Affinity Capture-Western
MAP3K5GNA1211038117595347 Affinity Capture-Western
MAP3K5GSTM110919912077134 Affinity Capture-Western
MAP3K5GSTM111038112077134 Affinity Capture-Western
MAP3K5HSPA1A10953512391142 Affinity Capture-Western; Reconstituted Complex
MAP3K5HSPA1A11038112391142 Affinity Capture-Western; Reconstituted Complex
TXNMAP3K51103819564042 11689443 12089063 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TXNMAP3K51131469564042 11689443 12089063 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF1MAP3K51130379774977 Affinity Capture-Western
TRAF1MAP3K51103819774977 Affinity Capture-Western
TRAF2MAP3K51103819774977 10523862 17015619 Affinity Capture-Western
TRAF2MAP3K51130389774977 10523862 17015619 Affinity Capture-Western
TRAF3MAP3K51130399774977 Affinity Capture-Western
TRAF3MAP3K51103819774977 Affinity Capture-Western
TRAF5MAP3K51130409774977 10523862 Affinity Capture-Western
TRAF5MAP3K51103819774977 10523862 Affinity Capture-Western
TRAF6MAP3K51130419774977 10523862 10921914 Affinity Capture-Western
TRAF6MAP3K51103819774977 10523862 10921914 Affinity Capture-Western
MAP3K6MAP3K51145249875215 11689443 Affinity Capture-Western; Two-hybrid
MAP3K6MAP3K51103819875215 11689443 Affinity Capture-Western; Two-hybrid
YWHAZMAP3K511336610411906 Affinity Capture-Western
YWHAZMAP3K511038110411906 Affinity Capture-Western
MAP3K7MAP3K511038110921914 Affinity Capture-Western; Two-hybrid
MAP3K7MAP3K511274810921914 Affinity Capture-Western; Two-hybrid
QARSMAP3K511179711096076 Affinity Capture-Western
QARSMAP3K511038111096076 Affinity Capture-Western
MAP3K5MAP3K511038111416155 11689443 11920685 Affinity Capture-Western
RAF1MAP3K511183111427728 Affinity Capture-Western; Reconstituted Complex
RAF1MAP3K511038111427728 Affinity Capture-Western; Reconstituted Complex
PPP5CMAP3K511152811689443 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression
PPP5CMAP3K511038111689443 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression
MAP2K6MAP3K511159411689443 12820963 Biochemical Activity; Reconstituted Complex
MAP2K6MAP3K511038111689443 12820963 Biochemical Activity; Reconstituted Complex
MAP2K7MAP3K511159511959862 Affinity Capture-Western
MAP2K7MAP3K511038111959862 Affinity Capture-Western
DUSP19MAP3K512677011959862 Affinity Capture-Western; Phenotypic Enhancement
DUSP19MAP3K511038111959862 Affinity Capture-Western; Phenotypic Enhancement
MAPK8IP3MAP3K511038112189133 Affinity Capture-Western; Biochemical Activity
MAPK8IP3MAP3K511677412189133 Affinity Capture-Western; Biochemical Activity
PDCD6MAP3K511038112372597 Affinity Capture-Western; Co-localization; Reconstituted Complex
PDCD6MAP3K511533312372597 Affinity Capture-Western; Co-localization; Reconstituted Complex
EIF2AK2MAP3K511159612473108 Affinity Capture-Western
EIF2AK2MAP3K511038112473108 Affinity Capture-Western
MLLMAP3K511044314607843 Affinity Capture-Western
MLLMAP3K511038114607843 Affinity Capture-Western
GADD45BMAP3K511070114743220 Affinity Capture-Western; Reconstituted Complex
GADD45BMAP3K511038114743220 Affinity Capture-Western; Reconstituted Complex
STUB1MAP3K511556316038411 17595347 Affinity Capture-Western
STUB1MAP3K511038116038411 17595347 Affinity Capture-Western
UBCMAP3K511316416038411 17595347 Affinity Capture-Western
UBCMAP3K511038116038411 17595347 Affinity Capture-Western
SOCS3MAP3K511448816407264 Affinity Capture-Western
SOCS3MAP3K511038116407264 Affinity Capture-Western
SOCS1MAP3K511420316407264 Affinity Capture-Western; Reconstituted Complex
SOCS1MAP3K511038116407264 Affinity Capture-Western; Reconstituted Complex
RB1CC1MAP3K511038117015619 Affinity Capture-Western
RB1CC1MAP3K511516017015619 Affinity Capture-Western
GNA13MAP3K511591417595347 Affinity Capture-Western
GNA13MAP3K511038117595347 Affinity Capture-Western
PRKAA2MAP3K511155020562859 Affinity Capture-MS
PRKAA2MAP3K511038120562859 Affinity Capture-MS
PRKAB2MAP3K511155220562859 Affinity Capture-MS
PRKAB2MAP3K511038120562859 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
MAP3K5GLRX26238112244106 GLRX (GRX) interacts with MAP3K5 (ASK1).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346876
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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