AutismKB 2.0

Annotation Details for MET


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Basic Information Top
Gene Symbol:MET ( AUTS9,HGFR,RCCP2,c-Met )
Gene Full Name: met proto-oncogene (hepatocyte growth factor receptor)
Band: 7q31
Quick LinksEntrez ID:4233; OMIM: 164860; Uniprot ID:MET_HUMAN; ENSEMBL ID: ENSG00000105976; HGNC ID: 7029
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005622IEA-intracellular-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane1846706
GO:0009925IDA-basal plasma membrane15314156
GO:0009986IDA-cell surface19581412
GO:0016021NAS-integral component of membrane2819873
GO ID Evidence Qualifier GO_term References
GO:0004713NAS-protein tyrosine kinase activity3325883
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005008TAS-hepatocyte growth factor-activated receptor activity10871856
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding1846706
GO:0005524IEA-ATP binding-
GO:0019903IPI-protein phosphatase binding18819921
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001886IDA-endothelial cell morphogenesis14500721
GO:0007165TAS-signal transduction1846706
GO:0007166NAS-cell surface receptor signaling pathway2819873
GO:0008283TAS-cell proliferation10871856
GO:0010507NAS-negative regulation of autophagy24743740
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0031116IMP-positive regulation of microtubule polymerization25198505
GO:0035024IDA-negative regulation of Rho protein signal transduction25198505
GO:0035635TAS-entry of bacterium into host cell-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter22521434
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048012IEA-hepatocyte growth factor receptor signaling pathway-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048754IMP-branching morphogenesis of an epithelial tube16153003
GO:0050918IDA-positive chemotaxis15218527
GO:0051497IDA-negative regulation of stress fiber assembly25198505
GO:0061436IMP-establishment of skin barrier25198505
GO:0070495IDA-negative regulation of thrombin-activated receptor signaling pathway25198505
GO:0071526IDA-semaphorin-plexin signaling pathway15218527
GO:1901299IMP-negative regulation of hydrogen peroxide-mediated programmed cell death20655899
GO:1905098IDA-negative regulation of guanyl-nucleotide exchange factor activity25198505
GO:2001028IMP-positive regulation of endothelial cell chemotaxis19850054
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
METCBL10731511894096 15123609 16397241 18273061 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex
METCBL11039111894096 15123609 16397241 18273061 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex
METCDH110743411254878 Affinity Capture-Western
METCDH111039111254878 Affinity Capture-Western
METCTNNB110788011254878 Affinity Capture-Western
METCTNNB111039111254878 Affinity Capture-Western
METGAB111039110871282 Affinity Capture-Western
METGAB110882410871282 Affinity Capture-Western
METGRB21091428662889 9660480 Affinity Capture-Western; Reconstituted Complex
METGRB21103918662889 9660480 Affinity Capture-Western; Reconstituted Complex
METHGF1103911655405 8380735 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
METHGF1093301655405 8380735 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT3MET1103919440692 Affinity Capture-Western
STAT3MET1126519440692 Affinity Capture-Western
SHC1MET1103919660480 Affinity Capture-Western
SHC1MET1123619660480 Affinity Capture-Western
SOS1MET1125379660480 Affinity Capture-Western
SOS1MET1103919660480 Affinity Capture-Western
SRCMET1103919837958 Affinity Capture-Western
SRCMET1125929837958 Affinity Capture-Western
GAB2MET11039110871282 Affinity Capture-Western
GAB2MET11518110871282 Affinity Capture-Western
GLMNMET11631811571281 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GLMNMET11039111571281 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SH3KBP1MET11902911894096 Affinity Capture-Western
SH3KBP1MET11039111894096 Affinity Capture-Western
RANBP9MET11535912147692 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RANBP9MET11039112147692 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RANBP10MET12165714684163 Affinity Capture-Western; Reconstituted Complex
RANBP10MET11039114684163 Affinity Capture-Western; Reconstituted Complex
UBCMET11039115123609 16397241 17449471 17679095 Affinity Capture-Western
UBCMET11316415123609 16397241 17449471 17679095 Affinity Capture-Western
LRIG1MET11039117178829 Affinity Capture-Western
LRIG1MET11748917178829 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
METGAB119476811894096 Met interacts with Gab1.
Gene Symbol Interactant Interaction ID References Description
METINPPL10290015735664 -
METINPPL10128015735664 -
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
METrs10215153, rs2237717, rs2283053, rs2299433, rs38841, rs38852, rs38857, rs41735, rs41741, rs6944417 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96969
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041014-1'