AutismKB 2.0

Annotation Details for MGMT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MGMT ( - )
Gene Full Name: O-6-methylguanine-DNA methyltransferase
Band: 10q26.3
Quick LinksEntrez ID:4255; OMIM: 156569; Uniprot ID:B4DEE8_HUMAN; ENSEMBL ID: ENSG00000170430; HGNC ID: 7059
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus2188979
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0016020IDA-membrane19946888
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003908IEA-methylated-DNA-[protein]-cysteine S-methyltransferase activity-
GO:0005509IEA-calcium ion binding-
GO:0008168TAS-methyltransferase activity2188979
GO:0009008TAS-DNA-methyltransferase activity2405387
GO ID Evidence Qualifier GO_term References
GO:0006266TAS-DNA ligation2188979
GO:0006306IEA-DNA methylation-
GO:0006307TAS-DNA dealkylation involved in DNA repair-
GO:0009636IEA-response to toxic substance-
GO:0034599IEA-cellular response to oxidative stress-
GO:0042493IEA-response to drug-
GO:0043066IDA-negative regulation of apoptotic process24147153
GO:0043281IEA-regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0045471IEA-response to ethanol-
GO:0051593IEA-response to folic acid-
GO:0060644IEA-mammary gland epithelial cell differentiation-
GO:0071407IEA-cellular response to organic cyclic compound-
GO:0071479IEA-cellular response to ionizing radiation-
GO:2000781IDA-positive regulation of double-strand break repair24147153
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MGMTACTB11041116226712 Affinity Capture-MS
MGMTACTB10657516226712 Affinity Capture-MS
MGMTSLC25A411041116226712 Affinity Capture-MS
MGMTSLC25A410678816226712 Affinity Capture-MS
MGMTSLC25A611041116226712 Affinity Capture-MS
MGMTSLC25A610679016226712 Affinity Capture-MS
MGMTANXA111041116226712 Affinity Capture-MS
MGMTANXA110679816226712 Affinity Capture-MS
MGMTANXA211041116226712 Affinity Capture-MS
MGMTANXA210679916226712 Affinity Capture-MS
MGMTCCNB111041116226712 Affinity Capture-Western
MGMTCCNB110733216226712 Affinity Capture-Western
MGMTCDK111041116226712 Affinity Capture-Western
MGMTCDK110742016226712 Affinity Capture-Western
MGMTCDK211041116226712 Affinity Capture-Western
MGMTCDK210745216226712 Affinity Capture-Western
MGMTCDKN1A11041116226712 Affinity Capture-Western
MGMTCDKN1A10746016226712 Affinity Capture-Western
MGMTCREBBP11041111564893 Affinity Capture-Western
MGMTCREBBP10777711564893 Affinity Capture-Western
MGMTCSNK2A111041110667577 Biochemical Activity
MGMTCSNK2A110784110667577 Biochemical Activity
MGMTCSNK2A210784210667577 Biochemical Activity
MGMTCSNK2A211041110667577 Biochemical Activity
MGMTDDX511041116226712 Affinity Capture-MS
MGMTDDX510802116226712 Affinity Capture-MS
MGMTEEF1A111041116226712 Affinity Capture-MS
MGMTEEF1A110823716226712 Affinity Capture-MS
MGMTEEF1A210823816226712 Affinity Capture-MS
MGMTEEF1A211041116226712 Affinity Capture-MS
MGMTEEF1B210825316226712 Affinity Capture-MS
MGMTEEF1B211041116226712 Affinity Capture-MS
MGMTEP30010834711564893 Affinity Capture-Western
MGMTEP30011041111564893 Affinity Capture-Western
MGMTFBL11041116226712 Affinity Capture-MS
MGMTFBL10839916226712 Affinity Capture-MS
MGMTESR110840311564893 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MGMTESR111041111564893 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MGMTXRCC610882216226712 Affinity Capture-MS
MGMTXRCC611041116226712 Affinity Capture-MS
MGMTHNRNPA2B110942216226712 Affinity Capture-MS
MGMTHNRNPA2B111041116226712 Affinity Capture-MS
MGMTHNRNPC10942416226712 Affinity Capture-MS
MGMTHNRNPC11041116226712 Affinity Capture-MS
MGMTHSP90AA111041116226712 Affinity Capture-MS; Affinity Capture-Western
MGMTHSP90AA110955216226712 Affinity Capture-MS; Affinity Capture-Western
MGMTHSP90AB110955816226712 Affinity Capture-MS
MGMTHSP90AB111041116226712 Affinity Capture-MS
MGMTKPNB111041116226712 Affinity Capture-MS
MGMTKPNB111003516226712 Affinity Capture-MS
MGMTMCM211041116226712 Affinity Capture-Western
MGMTMCM211033916226712 Affinity Capture-Western
MGMTMCM311041116226712 Affinity Capture-MS
MGMTMCM311034016226712 Affinity Capture-MS
PRKACAMGMT11155310667577 Biochemical Activity
PRKACAMGMT11041110667577 Biochemical Activity
PRKCAMGMT11156410667577 Biochemical Activity
PRKCAMGMT11041110667577 Biochemical Activity
UBCMGMT11041112016156 Reconstituted Complex
UBCMGMT11316412016156 Reconstituted Complex
TUBB2CMGMT11041116226712 Affinity Capture-MS
TUBB2CMGMT11565616226712 Affinity Capture-MS
USP19MGMT11607816226712 Affinity Capture-MS
USP19MGMT11041116226712 Affinity Capture-MS
FBXO27MGMT11041116226712 Affinity Capture-MS
FBXO27MGMT12599216226712 Affinity Capture-MS
FBXO2MGMT11041116226712 Affinity Capture-MS
FBXO2MGMT11762316226712 Affinity Capture-MS
H2BFMMGMT13037616226712 Affinity Capture-MS
H2BFMMGMT11041116226712 Affinity Capture-MS
MSH2MGMT11057316226712 Affinity Capture-MS
MSH2MGMT11041116226712 Affinity Capture-MS
MYO7AMGMT11073116226712 Affinity Capture-MS
MYO7AMGMT11041116226712 Affinity Capture-MS
NCLMGMT11077116226712 Affinity Capture-MS
NCLMGMT11041116226712 Affinity Capture-MS
PABPC3MGMT11107916226712 Affinity Capture-MS
PABPC3MGMT11041116226712 Affinity Capture-MS
CDK12MGMT11041116226712 Affinity Capture-MS
CDK12MGMT11971516226712 Affinity Capture-MS
PHBMGMT11126416226712 Affinity Capture-MS
PHBMGMT11041116226712 Affinity Capture-MS
PKM2MGMT11133216226712 Affinity Capture-MS
PKM2MGMT11041116226712 Affinity Capture-MS
PRKCHMGMT11156916226712 Affinity Capture-MS
PRKCHMGMT11041116226712 Affinity Capture-MS
PRKDCMGMT11157716226712 Affinity Capture-MS
PRKDCMGMT11041116226712 Affinity Capture-MS
DDX24MGMT12135316226712 Affinity Capture-MS
DDX24MGMT11041116226712 Affinity Capture-MS
PSMD9MGMT11168716226712 Affinity Capture-MS
PSMD9MGMT11041116226712 Affinity Capture-MS
PSME2MGMT11169316226712 Affinity Capture-MS
PSME2MGMT11041116226712 Affinity Capture-MS
PTPN4MGMT11174116226712 Affinity Capture-MS
PTPN4MGMT11041116226712 Affinity Capture-MS
RPLP1MGMT11041116226712 Affinity Capture-MS
RPLP1MGMT11209516226712 Affinity Capture-MS
RPS15AMGMT11212416226712 Affinity Capture-MS
RPS15AMGMT11041116226712 Affinity Capture-MS
SETMGMT11041116226712 Affinity Capture-MS
SETMGMT11231616226712 Affinity Capture-MS
IL25MGMT12231016226712 Affinity Capture-MS
IL25MGMT11041116226712 Affinity Capture-MS
SRP9MGMT11041116226712 Affinity Capture-MS
SRP9MGMT11260416226712 Affinity Capture-MS
SSRP1MGMT11041116226712 Affinity Capture-MS
SSRP1MGMT11262716226712 Affinity Capture-MS
CDKL5MGMT11041116226712 Affinity Capture-MS
CDKL5MGMT11266816226712 Affinity Capture-MS
TOP1MGMT11041116226712 Affinity Capture-MS
TOP1MGMT11300316226712 Affinity Capture-MS
TTPAMGMT11041116226712 Affinity Capture-MS
TTPAMGMT11312516226712 Affinity Capture-MS
UBBMGMT11316216226712 Affinity Capture-MS
UBBMGMT11041116226712 Affinity Capture-MS
VIMMGMT11041116226712 Affinity Capture-MS
VIMMGMT11327216226712 Affinity Capture-MS
WNT9BMGMT11041116226712 Affinity Capture-MS
WNT9BMGMT11332116226712 Affinity Capture-MS
YWHAZMGMT11041116226712 Affinity Capture-MS
YWHAZMGMT11336616226712 Affinity Capture-MS
ANP32EMGMT11041116226712 Affinity Capture-MS
ANP32EMGMT12354816226712 Affinity Capture-MS
SMC1AMGMT11041116226712 Affinity Capture-MS
SMC1AMGMT11387116226712 Affinity Capture-MS
HIST3H3MGMT11041116226712 Affinity Capture-MS
HIST3H3MGMT11389516226712 Affinity Capture-MS
HIST1H2AMMGMT11041116226712 Affinity Capture-MS
HIST1H2AMMGMT11393216226712 Affinity Capture-MS
HIST1H4AMGMT11041116226712 Affinity Capture-MS
HIST1H4AMGMT11395516226712 Affinity Capture-MS
TUBA1CMGMT11041116226712 Affinity Capture-MS
TUBA1CMGMT12425916226712 Affinity Capture-MS
CDK10MGMT11041116226712 Affinity Capture-MS
CDK10MGMT11412816226712 Affinity Capture-MS
EIF3HMGMT11041116226712 Affinity Capture-MS
EIF3HMGMT11421616226712 Affinity Capture-MS
RNF8MGMT11449216226712 Affinity Capture-MS
RNF8MGMT11041116226712 Affinity Capture-MS
PRPF4MGMT11041116226712 Affinity Capture-MS
PRPF4MGMT11457616226712 Affinity Capture-MS
ORC1MGMT11104016226712 Affinity Capture-Western
ORC1MGMT11041116226712 Affinity Capture-Western
PCNAMGMT11114216226712 Affinity Capture-Western
PCNAMGMT11041116226712 Affinity Capture-Western
POLD1MGMT11142016226712 Affinity Capture-Western
POLD1MGMT11041116226712 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96977
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved