AutismKB 2.0

Annotation Details for CIITA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CIITA ( C2TA,CIITAIV,MHC2TA,NLRA )
Gene Full Name: class II, major histocompatibility complex, transactivator
Band: 16p13.13
Quick LinksEntrez ID:4261; OMIM: 600005; Uniprot ID:C2TA_HUMAN; ENSEMBL ID: ENSG00000179583; HGNC ID: 7067
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0016605IDA-PML body23007646
GO ID Evidence Qualifier GO_term References
GO:0003677TASNOTDNA binding15771576
GO:0003713TAS-transcription coactivator activity7749984
GO:0005515IPI-protein binding16600381
GO:0005524IEA-ATP binding-
GO:0005525IEA-GTP binding-
GO:0008022IPI-protein C-terminus binding16600381
GO:0016301IEA-kinase activity-
GO:0016746IEA-transferase activity, transferring acyl groups-
GO:0032403IDA-protein complex binding17493635
GO:0033613IPI-activating transcription factor binding9171108
GO:0044212IDA-transcription regulatory region DNA binding19041327
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter19041327
GO:0006351IEA-transcription, DNA-templated-
GO:0006955TAS-immune response8402893
GO:0016310IEA-phosphorylation-
GO:0032966IC-negative regulation of collagen biosynthetic process19041327
GO:0034341IDA-response to interferon-gamma19041327
GO:0045345IDA-positive regulation of MHC class I biosynthetic process20639463
GO:0045348IC-positive regulation of MHC class II biosynthetic process9171108
GO:0045892IDA-negative regulation of transcription, DNA-templated19041327
GO:0045893IDA-positive regulation of transcription, DNA-templated19041327
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter20639463
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter9171108
GO:0046677IDA-response to antibiotic107465
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CIITACDK111041618245089 Biochemical Activity
CIITACDK110742018245089 Biochemical Activity
CIITAGSK3B11041617991736 Biochemical Activity
CIITAGSK3B10918717991736 Biochemical Activity
CIITAHDAC110931512697811 Reconstituted Complex
CIITAHDAC111041612697811 Reconstituted Complex
CIITAHDAC210931612697811 17991736 19041327 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
CIITAHDAC211041612697811 17991736 19041327 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RFX5CIITA1104169177217 11003667 12697811 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
RFX5CIITA1119259177217 11003667 12697811 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
RFXANKCIITA11041611003667 11463838 Affinity Capture-Western; Reconstituted Complex
RFXANKCIITA11418011003667 11463838 Affinity Capture-Western; Reconstituted Complex
SMARCA4CIITA11248112077331 Reconstituted Complex
SMARCA4CIITA11041612077331 Reconstituted Complex
XPO1CIITA11041612517958 18245089 Affinity Capture-Western; Reconstituted Complex
XPO1CIITA11334812517958 18245089 Affinity Capture-Western; Reconstituted Complex
NCOA1CIITA11041612933903 Affinity Capture-Western; Reconstituted Complex
NCOA1CIITA11420012933903 Affinity Capture-Western; Reconstituted Complex
HDAC5CIITA11533115964851 Affinity Capture-Western
HDAC5CIITA11041615964851 Affinity Capture-Western
HDAC4CIITA11510615964851 Affinity Capture-Western
HDAC4CIITA11041615964851 Affinity Capture-Western
SIN3BCIITA11690117991736 Affinity Capture-Western
SIN3BCIITA11041617991736 Affinity Capture-Western
MAPK3CIITA11158118245089 Affinity Capture-Western
MAPK3CIITA11041618245089 Affinity Capture-Western
MAPK1CIITA11041618245089 Affinity Capture-Western; Biochemical Activity
MAPK1CIITA11158018245089 Affinity Capture-Western; Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:108445
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-071116-6'