AutismKB 2.0

Annotation Details for MIF


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Basic Information Top
Gene Symbol:MIF ( GIF,GLIF,MMIF )
Gene Full Name: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Band: 22q11.23
Quick LinksEntrez ID:4282; OMIM: 153620; Uniprot ID:MIF_HUMAN; ENSEMBL ID: ENSG00000133460; HGNC ID: 7097
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region12782713
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0009986IDA-cell surface12782713
GO:0031982IDA-vesicle19190083
GO:0034774TAS-secretory granule lumen-
GO:0043209IEA-myelin sheath-
GO:0070062IDA-extracellular exosome19056867
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004167IDA-dopachrome isomerase activity17526494
GO:0005102IPI-receptor binding12782713
GO:0005125IDA-cytokine activity12782713
GO:0005126IPI-cytokine receptor binding17045821
GO:0005515IPI-protein binding12681488
GO:0042056IDA-chemoattractant activity19602265
GO:0050178IDA-phenylpyruvate tautomerase activity16285950
GO ID Evidence Qualifier GO_term References
GO:0001516IDA-prostaglandin biosynthetic process12782713
GO:0002906IEA-negative regulation of mature B cell apoptotic process-
GO:0006954IEA-inflammatory response-
GO:0007166IDA-cell surface receptor signaling pathway12782713
GO:0007569IEA-cell aging-
GO:0008283IDA-cell proliferation12782713
GO:0010629IDA-negative regulation of gene expression10562313
GO:0010739IDA-positive regulation of protein kinase A signaling17045821
GO:0019752IDA-carboxylic acid metabolic process12782713
GO:0030330IEA-DNA damage response, signal transduction by p53 class mediator-
GO:0030890IDA-positive regulation of B cell proliferation12782713
GO:0031666IEA-positive regulation of lipopolysaccharide-mediated signaling pathway-
GO:0032269IEA-negative regulation of cellular protein metabolic process-
GO:0033033IEA-negative regulation of myeloid cell apoptotic process-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation17045821
GO:0042327IDA-positive regulation of phosphorylation12782713
GO:0043030NAS-regulation of macrophage activation12782713
GO:0043066IDA-negative regulation of apoptotic process12782713
GO:0043312TAS-neutrophil degranulation-
GO:0043406IEA-positive regulation of MAP kinase activity-
GO:0043518IDA-negative regulation of DNA damage response, signal transduction by p53 class mediator17045821
GO:0045087IEA-innate immune response-
GO:0048146IDA-positive regulation of fibroblast proliferation12782713
GO:0050715IDA-positive regulation of cytokine secretion19602265
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation17045821
GO:0050900TAS-leukocyte migration-
GO:0050918IEA-positive chemotaxis-
GO:0061078IEA-positive regulation of prostaglandin secretion involved in immune response-
GO:0061081IEA-positive regulation of myeloid leukocyte cytokine production involved in immune response-
GO:0070207IPI-protein homotrimerization17526494
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade12782713
GO:0071157IDA-negative regulation of cell cycle arrest10562313
GO:0090238IEA-positive regulation of arachidonic acid secretion-
GO:0090344IDA-negative regulation of cell aging10562313
GO:1902166IDA-negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator17045821
GO:2000343IEA-positive regulation of chemokine (C-X-C motif) ligand 2 production-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MIFCD7411042812782713 Affinity Capture-Western; Reconstituted Complex
MIFCD7410741012782713 Affinity Capture-Western; Reconstituted Complex
COPS5MIF11618311089976 Affinity Capture-Western; Reconstituted Complex
COPS5MIF11042811089976 Affinity Capture-Western; Reconstituted Complex
BNIPLMIF12721112681488 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BNIPLMIF11042812681488 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GORASP2MIF11042816189514 Two-hybrid
GORASP2MIF11747916189514 Two-hybrid
FIBPMIF11460317353931 Affinity Capture-MS
FIBPMIF11042817353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
MIFrs755622 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
MIFMIF_-173C/G, MIF_4pbSTR Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96982
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080708-1'