AutismKB 2.0

Annotation Details for MLH1


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Basic Information Top
Gene Symbol:MLH1 ( COCA2,FCC2,HNPCC,HNPCC2,MGC5172,hMLH1 )
Gene Full Name: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Band: 3p22.2
Quick LinksEntrez ID:4292; OMIM: 120436; Uniprot ID:MLH1_HUMAN; ENSEMBL ID: ENSG00000076242; HGNC ID: 7127
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000795IBA-synaptonemal complex-
GO:0001673IEA-male germ cell nucleus-
GO:0005634IC-nucleus11809883
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005712IBA-chiasma-
GO:0005715IEA-late recombination nodule-
GO:0016020IDA-membrane19946888
GO:0032389IBA-MutLalpha complex-
GO ID Evidence Qualifier GO_term References
GO:0003682IEA-chromatin binding-
GO:0003697IDAcontributes_tosingle-stranded DNA binding11809883
GO:0005515IPI-protein binding2414623
GO:0005515IPIcontributes_toprotein binding16403449
GO:0005524IEA-ATP binding-
GO:0016887IBA-ATPase activity-
GO:0032137IEA-guanine/thymine mispair binding-
GO:0032407IDAcontributes_toMutSalpha complex binding16403449
GO ID Evidence Qualifier GO_term References
GO:0000289IEA-nuclear-transcribed mRNA poly(A) tail shortening-
GO:0000712IEA-resolution of meiotic recombination intermediates-
GO:0006298IGI-mismatch repair23603115
GO:0006298TAS-mismatch repair-
GO:0006303IEA-double-strand break repair via nonhomologous end joining-
GO:0007060IEA-male meiosis chromosome segregation-
GO:0007129IEA-synapsis-
GO:0007283IEA-spermatogenesis-
GO:0008630IEA-intrinsic apoptotic signaling pathway in response to DNA damage-
GO:0016321IEA-female meiosis chromosome segregation-
GO:0016446IBA-somatic hypermutation of immunoglobulin genes-
GO:0043060IEA-meiotic metaphase I plate congression-
GO:0045141IEA-meiotic telomere clustering-
GO:0045190IEA-isotype switching-
GO:0045950IEA-negative regulation of mitotic recombination-
GO:0048298IEA-positive regulation of isotype switching to IgA isotypes-
GO:0048304IEA-positive regulation of isotype switching to IgG isotypes-
GO:0048477IEA-oogenesis-
GO:0051257IEA-meiotic spindle midzone assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MLH1AP2B110667216189514 Two-hybrid
MLH1AP2B111043816189514 Two-hybrid
MLH1ATM11043810783165 Co-purification
MLH1ATM10696210783165 Co-purification
MLH1ATP5A110698717148452 Affinity Capture-MS
MLH1ATP5A111043817148452 Affinity Capture-MS
MLH1BLM11043810783165 11325959 11470874 11691925 19015241 Affinity Capture-Western; Co-purification; Far Western; Protein-peptide; Reconstituted Complex; Two-hybrid
MLH1BLM10711010783165 11325959 11470874 11691925 19015241 Affinity Capture-Western; Co-purification; Far Western; Protein-peptide; Reconstituted Complex; Two-hybrid
MLH1BRCA110714010783165 17148452 21240188 Affinity Capture-MS; Affinity Capture-Western; Co-purification
MLH1BRCA111043810783165 17148452 21240188 Affinity Capture-MS; Affinity Capture-Western; Co-purification
MLH1MSH610921110783165 Co-purification
MLH1MSH611043810783165 Co-purification
MLH1KPNB111043817148452 Affinity Capture-MS
MLH1KPNB111003517148452 Affinity Capture-MS
MLH1KPNA211003617148452 Affinity Capture-MS
MLH1KPNA211043817148452 Affinity Capture-MS
PMS2MLH111043810037723 11292842 12584560 17148452 19015241 20978114 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PMS2MLH111140410037723 11292842 12584560 17148452 19015241 20978114 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MBD4MLH111043810097147 Affinity Capture-Western; Two-hybrid
MBD4MLH111444410097147 Affinity Capture-Western; Two-hybrid
RAD50MLH111043810783165 Co-purification
RAD50MLH111541710783165 Co-purification
MRE11AMLH111043810783165 Co-purification
MRE11AMLH111050110783165 Co-purification
MSH2MLH111057310783165 Co-purification
MSH2MLH111043810783165 Co-purification
NBNMLH111076310783165 Co-purification
NBNMLH111043810783165 Co-purification
RFC1MLH111043810783165 Co-purification
RFC1MLH111191310783165 Co-purification
MSH4MLH111043810928988 Affinity Capture-Western; Reconstituted Complex
MSH4MLH111057510928988 Affinity Capture-Western; Reconstituted Complex
PMS1MLH111043811292842 17148452 20004149 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Two-hybrid
PMS1MLH111139111292842 17148452 20004149 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Two-hybrid
MLH3MLH111043811292842 Two-hybrid
MLH3MLH111796111292842 Two-hybrid
EXO1MLH111043811427529 17148452 19015241 Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex
EXO1MLH111460211427529 17148452 19015241 Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex
MYCMLH111043812584560 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MYCMLH111069412584560 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FRMD6MLH111043816189514 Two-hybrid
FRMD6MLH112579516189514 Two-hybrid
UBOX5MLH111043816189514 Two-hybrid
UBOX5MLH111655416189514 Two-hybrid
TRIM29MLH111043816189514 Two-hybrid
TRIM29MLH111717716189514 Two-hybrid
ZC3H11AMLH111043816189514 Two-hybrid
ZC3H11AMLH111520816189514 Two-hybrid
RUVBL2MLH111043817148452 Affinity Capture-MS
RUVBL2MLH111606717148452 Affinity Capture-MS
AMOTMLH111043817148452 Affinity Capture-MS
AMOTMLH112755717148452 Affinity Capture-MS
PSD3MLH111043817148452 Affinity Capture-MS
PSD3MLH111694317148452 Affinity Capture-MS
MSH3MLH111043817148452 Affinity Capture-MS
MSH3MLH111057417148452 Affinity Capture-MS
PIK3C2AMLH111043817148452 Affinity Capture-MS
PIK3C2AMLH111130417148452 Affinity Capture-MS
XRN1MLH111043817148452 Affinity Capture-MS
XRN1MLH111997017148452 Affinity Capture-MS
PPP2R1AMLH111043817148452 Affinity Capture-MS
PPP2R1AMLH111151017148452 Affinity Capture-MS
PPP2R2AMLH111043817148452 Affinity Capture-MS
PPP2R2AMLH111151217148452 Affinity Capture-MS
PPP2R2BMLH111043817148452 Affinity Capture-MS
PPP2R2BMLH111151317148452 Affinity Capture-MS
ATAD3AMLH111043817148452 Affinity Capture-MS
ATAD3AMLH112050617148452 Affinity Capture-MS
PPP3CBMLH111043817148452 Affinity Capture-MS
PPP3CBMLH111152417148452 Affinity Capture-MS
PPP3CCMLH111043817148452 Affinity Capture-MS
PPP3CCMLH111152517148452 Affinity Capture-MS
PPP2R2DMLH111043817148452 Affinity Capture-MS
PPP2R2DMLH112094617148452 Affinity Capture-MS
PRKDCMLH111043817148452 Affinity Capture-MS
PRKDCMLH111157717148452 Affinity Capture-MS
YLPM1MLH111043817148452 Affinity Capture-MS
YLPM1MLH112111717148452 Affinity Capture-MS
PYGBMLH111043817148452 Affinity Capture-MS
PYGBMLH111179217148452 Affinity Capture-MS
UBCMLH111043817148452 Affinity Capture-MS
UBCMLH111316417148452 Affinity Capture-MS
WDR61MLH111043817148452 Affinity Capture-MS
WDR61MLH112325517148452 Affinity Capture-MS
SMC1AMLH111043817148452 Affinity Capture-MS
SMC1AMLH111387117148452 Affinity Capture-MS
ATAD3BMLH111043817148452 Affinity Capture-MS
ATAD3BMLH112377417148452 Affinity Capture-MS
DOCK7MLH111043817148452 Affinity Capture-MS
DOCK7MLH112452717148452 Affinity Capture-MS
RUVBL1MLH111043817148452 Affinity Capture-MS
RUVBL1MLH111416617148452 Affinity Capture-MS
AIFM1MLH111043817148452 Affinity Capture-MS
AIFM1MLH111457917148452 Affinity Capture-MS
UBAP2LMLH111043817148452 Affinity Capture-MS
UBAP2LMLH111522717148452 Affinity Capture-MS
FAN1MLH111043817148452 20603015 20603073 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
FAN1MLH111657317148452 20603015 20603073 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BRIP1MLH111043817148452 20173781 20978114 Affinity Capture-Western
BRIP1MLH112384117148452 20173781 20978114 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:101938
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1600'