AutismKB 2.0

Annotation Details for MAP3K10


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Basic Information Top
Gene Symbol:MAP3K10 ( MEKK10,MLK2,MST )
Gene Full Name: mitogen-activated protein kinase kinase kinase 10
Band: 19q13.2
Quick LinksEntrez ID:4294; OMIM: 600137; Uniprot ID:M3K10_HUMAN; ENSEMBL ID: ENSG00000130758; HGNC ID: 6849
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm18455992
GO ID Evidence Qualifier GO_term References
GO:0003714ISS-transcription corepressor activity-
GO:0004672TAS-protein kinase activity8536694
GO:0004674IDA-protein serine/threonine kinase activity19801649
GO:0004706IBA-JUN kinase kinase kinase activity-
GO:0004706ISS-JUN kinase kinase kinase activity-
GO:0005524IEA-ATP binding-
GO:0042803ISS-protein homodimerization activity8195146
GO:0043425IPI-bHLH transcription factor binding19801649
GO ID Evidence Qualifier GO_term References
GO:0006915TAS-apoptotic process10801775
GO:0007165TAS-signal transduction10801775
GO:0007224IMP-smoothened signaling pathway18455992
GO:0007254TAS-JNK cascade10801775
GO:0007256IEA-activation of JNKK activity-
GO:0007257IBA-activation of JUN kinase activity-
GO:0007257ISS-activation of JUN kinase activity8195146
GO:0018105IDA-peptidyl-serine phosphorylation19801649
GO:0018107IDA-peptidyl-threonine phosphorylation19801649
GO:0043065IBA-positive regulation of apoptotic process-
GO:0043433IMP-negative regulation of sequence-specific DNA binding transcription factor activity19801649
GO:0043507IMP-positive regulation of JUN kinase activity17584736
GO:0045892IMP-negative regulation of transcription, DNA-templated19801649
GO:0045892ISS-negative regulation of transcription, DNA-templated-
GO:0046330IMP-positive regulation of JNK cascade17584736
GO:0046777ISS-protein autophosphorylation8195146
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K10ABL211044020936779 Two-hybrid
MAP3K10ABL210654520936779 Two-hybrid
MAP3K10CDC421104409427749 Reconstituted Complex; Two-hybrid
MAP3K10CDC421074339427749 Reconstituted Complex; Two-hybrid
MAP3K10CLTC11044012105200 Affinity Capture-Western
MAP3K10CLTC10762312105200 Affinity Capture-Western
MAP3K10DLG411044011152698 Affinity Capture-Western
MAP3K10DLG410808611152698 Affinity Capture-Western
MAP3K10DNM11080999742220 Reconstituted Complex
MAP3K10DNM11104409742220 Reconstituted Complex
MAP3K10HTT11044010801775 Affinity Capture-Western
MAP3K10HTT10931410801775 Affinity Capture-Western
MAP3K10HPCA1104409427749 Affinity Capture-Western
MAP3K10HPCA1094489427749 Affinity Capture-Western
MAP2K4MAP3K101104409182538 Biochemical Activity
MAP2K4MAP3K101123159182538 Biochemical Activity
YWHAEMAP3K101133639427749 Affinity Capture-Western
YWHAEMAP3K101104409427749 Affinity Capture-Western
KRTAP3-4PMAP3K101244799427749 Affinity Capture-Western
KRTAP3-4PMAP3K101104409427749 Affinity Capture-Western
KIF3AMAP3K101104409427749 Affinity Capture-Western; Two-hybrid
KIF3AMAP3K101163009427749 Affinity Capture-Western; Two-hybrid
RAC1MAP3K101104409427749 Reconstituted Complex
RAC1MAP3K101118179427749 Reconstituted Complex
KIFAP3MAP3K101165829427749 Two-hybrid
KIFAP3MAP3K101104409427749 Two-hybrid
KIF17MAP3K101216299427749 Two-hybrid
KIF17MAP3K101104409427749 Two-hybrid
MAPK8IP2MAP3K1011044010490659 Affinity Capture-Western; Reconstituted Complex
MAPK8IP2MAP3K1011708610490659 Affinity Capture-Western; Reconstituted Complex
MAPK8IP1MAP3K1011044010490659 Affinity Capture-Western; Reconstituted Complex
MAPK8IP1MAP3K1011486410490659 Affinity Capture-Western; Reconstituted Complex
NEUROD1MAP3K1011044012881483 Affinity Capture-Western; Biochemical Activity; Two-hybrid
NEUROD1MAP3K1011083312881483 Affinity Capture-Western; Biochemical Activity; Two-hybrid
HGSMAP3K1011044019019082 Reconstituted Complex
HGSMAP3K1011459319019082 Reconstituted Complex
KIAA1804MAP3K1011044020936779 Two-hybrid
KIAA1804MAP3K1012408920936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
MAP3K10HTT12823310801775 MLK2 SH3 domain interacts with Huntingtin
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346879
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050419-112'