Annotation Details for MLL
Basic Information Top
Gene Symbol: | MLL ( ALL-1,CXXC7,FLJ11783,HRX,HTRX1,KMT2A,MLL/GAS7,MLL1A,TET1-MLL,TRX1 ) |
---|---|
Gene Full Name: | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) |
Band: | 11q23 |
Quick Links | Entrez ID:4297; OMIM: 159555; Uniprot ID:MLL1_HUMAN; ENSEMBL ID: ENSG00000118058; HGNC ID: |
Relate to Another Database: | SFARIGene; denovo-db |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0005634 | IDA | - | nucleus | 11313484 |
GO:0005634 | NAS | - | nucleus | 1423624 |
GO:0005654 | IDA | - | nucleoplasm | - |
GO:0005654 | TAS | - | nucleoplasm | - |
GO:0005829 | IDA | - | cytosol | - |
GO:0035097 | IDA | - | histone methyltransferase complex | 19556245 |
GO:0071339 | IDA | - | MLL1 complex | 15960975 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0001046 | ISS | - | core promoter sequence-specific DNA binding | - |
GO:0003680 | NAS | - | AT DNA binding | 1423624 |
GO:0003682 | IEA | - | chromatin binding | - |
GO:0003700 | NAS | - | transcription factor activity, sequence-specific DNA binding | 10821850 |
GO:0005515 | IPI | - | protein binding | 11313484 |
GO:0008270 | IDA | - | zinc ion binding | 16990798 |
GO:0018024 | TAS | - | histone-lysine N-methyltransferase activity | - |
GO:0042800 | IDA | - | histone methyltransferase activity (H3-K4 specific) | 19187761 |
GO:0042800 | IMP | - | histone methyltransferase activity (H3-K4 specific) | 15960975 |
GO:0042802 | IPI | - | identical protein binding | 10656681 |
GO:0042803 | IDA | - | protein homodimerization activity | 11313484 |
GO:0044212 | IDA | - | transcription regulatory region DNA binding | 20484083 |
GO:0045322 | IDA | - | unmethylated CpG binding | 16990798 |
GO:0070577 | IDA | - | lysine-acetylated histone binding | 19187761 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0006306 | IEA | - | DNA methylation | - |
GO:0006366 | TAS | - | transcription from RNA polymerase II promoter | 10821850 |
GO:0006461 | IDA | - | protein complex assembly | 15199122 |
GO:0006915 | IEA | - | apoptotic process | - |
GO:0008285 | IEA | - | negative regulation of cell proliferation | - |
GO:0008542 | IEA | - | visual learning | - |
GO:0009791 | IEA | - | post-embryonic development | - |
GO:0009952 | IEA | - | anterior/posterior pattern specification | - |
GO:0018026 | IEA | - | peptidyl-lysine monomethylation | - |
GO:0032411 | IMP | - | positive regulation of transporter activity | 20861184 |
GO:0032922 | ISS | - | circadian regulation of gene expression | - |
GO:0035162 | TAS | - | embryonic hemopoiesis | 15618964 |
GO:0035640 | IEA | - | exploration behavior | - |
GO:0035864 | IEA | - | response to potassium ion | - |
GO:0043984 | IMP | - | histone H4-K16 acetylation | 15960975 |
GO:0044648 | IEA | - | histone H3-K4 dimethylation | - |
GO:0045893 | IMP | - | positive regulation of transcription, DNA-templated | 15960975 |
GO:0045944 | IDA | - | positive regulation of transcription from RNA polymerase II promoter | 20861184 |
GO:0048172 | IEA | - | regulation of short-term neuronal synaptic plasticity | - |
GO:0048536 | IEA | - | spleen development | - |
GO:0048873 | IEA | - | homeostasis of number of cells within a tissue | - |
GO:0051568 | IDA | - | histone H3-K4 methylation | 19556245 |
GO:0051568 | IMP | - | histone H3-K4 methylation | 15960975 |
GO:0051571 | ISS | - | positive regulation of histone H3-K4 methylation | - |
GO:0051899 | IEA | - | membrane depolarization | - |
GO:0060216 | IEA | - | definitive hemopoiesis | - |
GO:0071440 | ISS | - | regulation of histone H3-K14 acetylation | - |
GO:0080182 | IDA | - | histone H3-K4 trimethylation | 20861184 |
GO:1901674 | IEA | - | regulation of histone H3-K27 acetylation | - |
GO:2000615 | ISS | - | regulation of histone H3-K9 acetylation | - |
GO:2001040 | IMP | - | positive regulation of cellular response to drug | 20861184 |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
MLL | AVP | 110443 | 14607844 | Biochemical Activity |
MLL | AVP | 107032 | 14607844 | Biochemical Activity |
MLL | BMI1 | 110443 | 12829790 | Reconstituted Complex |
MLL | BMI1 | 107116 | 12829790 | Reconstituted Complex |
MLL | CREBBP | 110443 | 11259575 12205094 | Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid |
MLL | CREBBP | 107777 | 11259575 12205094 | Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid |
MLL | CTBP1 | 110443 | 12829790 | Affinity Capture-Western; Reconstituted Complex |
MLL | CTBP1 | 107869 | 12829790 | Affinity Capture-Western; Reconstituted Complex |
MLL | CTNNB1 | 110443 | 16510874 16510875 | Affinity Capture-MS; Reconstituted Complex |
MLL | CTNNB1 | 107880 | 16510874 16510875 | Affinity Capture-MS; Reconstituted Complex |
MLL | E2F2 | 110443 | 16951254 | Affinity Capture-Western |
MLL | E2F2 | 108202 | 16951254 | Affinity Capture-Western |
MLL | E2F4 | 110443 | 16951254 | Affinity Capture-Western |
MLL | E2F4 | 108206 | 16951254 | Affinity Capture-Western |
MLL | E2F6 | 108208 | 16951254 | Affinity Capture-Western |
MLL | E2F6 | 110443 | 16951254 | Affinity Capture-Western |
MLL | HCFC1 | 110443 | 15199122 | Affinity Capture-Western; Co-purification |
MLL | HCFC1 | 109304 | 15199122 | Affinity Capture-Western; Co-purification |
MLL | HDAC1 | 109315 | 12829790 | Affinity Capture-Western; Reconstituted Complex |
MLL | HDAC1 | 110443 | 12829790 | Affinity Capture-Western; Reconstituted Complex |
MLL | INS | 109842 | 14607844 | Biochemical Activity |
MLL | INS | 110443 | 14607844 | Biochemical Activity |
MLL | MAP3K5 | 110443 | 14607843 | Affinity Capture-Western |
MLL | MAP3K5 | 110381 | 14607843 | Affinity Capture-Western |
MLL | MEN1 | 110443 | 15199122 16199523 16239140 16618927 17671196 19818711 20064463 | Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex |
MLL | MEN1 | 110384 | 15199122 16199523 16239140 16618927 17671196 19818711 20064463 | Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex |
SET | MLL | 110443 | 9353299 | Reconstituted Complex; Two-hybrid |
SET | MLL | 112316 | 9353299 | Reconstituted Complex; Two-hybrid |
MTM1 | MLL | 110443 | 9537414 | Reconstituted Complex |
MTM1 | MLL | 110630 | 9537414 | Reconstituted Complex |
SBF1 | MLL | 110443 | 9537414 | Reconstituted Complex |
SBF1 | MLL | 112212 | 9537414 | Reconstituted Complex |
SMARCB1 | MLL | 112482 | 10490642 | Affinity Capture-Western |
SMARCB1 | MLL | 110443 | 10490642 | Affinity Capture-Western |
PPP1R15A | MLL | 117172 | 10490642 | Affinity Capture-Western; Two-hybrid |
PPP1R15A | MLL | 110443 | 10490642 | Affinity Capture-Western; Two-hybrid |
MLL | MLL | 110443 | 11313484 12393701 12482972 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
PPIE | MLL | 115714 | 11313484 18676843 | Affinity Capture-Western; Two-hybrid |
PPIE | MLL | 110443 | 11313484 18676843 | Affinity Capture-Western; Two-hybrid |
CBX4 | MLL | 110443 | 12829790 | Reconstituted Complex |
CBX4 | MLL | 114105 | 12829790 | Reconstituted Complex |
OXT | MLL | 111060 | 14607844 | Biochemical Activity |
OXT | MLL | 110443 | 14607844 | Biochemical Activity |
RBBP5 | MLL | 110443 | 15199122 15960975 20064463 | Affinity Capture-Western; Co-localization; Co-purification |
RBBP5 | MLL | 111864 | 15199122 15960975 20064463 | Affinity Capture-Western; Co-localization; Co-purification |
ASH2L | MLL | 110443 | 15199122 20064463 | Affinity Capture-Western; Co-localization; Co-purification |
ASH2L | MLL | 114528 | 15199122 20064463 | Affinity Capture-Western; Co-localization; Co-purification |
HCFC2 | MLL | 118959 | 15199122 | Affinity Capture-Western; Co-purification |
HCFC2 | MLL | 110443 | 15199122 | Affinity Capture-Western; Co-purification |
WDR5 | MLL | 110443 | 15199122 18840606 | Affinity Capture-Western; Co-purification; Reconstituted Complex |
WDR5 | MLL | 116272 | 15199122 18840606 | Affinity Capture-Western; Co-purification; Reconstituted Complex |
RNF2 | MLL | 111972 | 15960975 | Affinity Capture-Western |
RNF2 | MLL | 110443 | 15960975 | Affinity Capture-Western |
MYST1 | MLL | 110443 | 15960975 | Affinity Capture-Western |
MYST1 | MLL | 123914 | 15960975 | Affinity Capture-Western |
TP53 | MLL | 110443 | 15960975 | Reconstituted Complex |
TP53 | MLL | 113010 | 15960975 | Reconstituted Complex |
POLR2A | MLL | 110443 | 16199523 | Affinity Capture-Western; Co-localization; Reconstituted Complex |
POLR2A | MLL | 111426 | 16199523 | Affinity Capture-Western; Co-localization; Reconstituted Complex |
MLLT4 | MLL | 110443 | 16239140 | Affinity Capture-Western |
MLLT4 | MLL | 110447 | 16239140 | Affinity Capture-Western |
CXXC1 | MLL | 119045 | 18082152 | Affinity Capture-Western |
CXXC1 | MLL | 110443 | 18082152 | Affinity Capture-Western |
PSIP1 | MLL | 110443 | 18598942 | Affinity Capture-Western |
PSIP1 | MLL | 116339 | 18598942 | Affinity Capture-Western |
SNW1 | MLL | 110443 | 19818711 | Affinity Capture-Western |
SNW1 | MLL | 116597 | 19818711 | Affinity Capture-Western |
MYB | MLL | 110687 | 20093773 | Affinity Capture-Western |
MYB | MLL | 110443 | 20093773 | Affinity Capture-Western |
No data |
No data |
- MGI ID: MGI:96995
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-080521-3