AutismKB 2.0

Annotation Details for MLL


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Basic Information Top
Gene Symbol:MLL ( ALL-1,CXXC7,FLJ11783,HRX,HTRX1,KMT2A,MLL/GAS7,MLL1A,TET1-MLL,TRX1 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
Band: 11q23
Quick LinksEntrez ID:4297; OMIM: 159555; Uniprot ID:MLL1_HUMAN; ENSEMBL ID: ENSG00000118058; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11313484
GO:0005634NAS-nucleus1423624
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0035097IDA-histone methyltransferase complex19556245
GO:0071339IDA-MLL1 complex15960975
GO ID Evidence Qualifier GO_term References
GO:0001046ISS-core promoter sequence-specific DNA binding-
GO:0003680NAS-AT DNA binding1423624
GO:0003682IEA-chromatin binding-
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding10821850
GO:0005515IPI-protein binding11313484
GO:0008270IDA-zinc ion binding16990798
GO:0018024TAS-histone-lysine N-methyltransferase activity-
GO:0042800IDA-histone methyltransferase activity (H3-K4 specific)19187761
GO:0042800IMP-histone methyltransferase activity (H3-K4 specific)15960975
GO:0042802IPI-identical protein binding10656681
GO:0042803IDA-protein homodimerization activity11313484
GO:0044212IDA-transcription regulatory region DNA binding20484083
GO:0045322IDA-unmethylated CpG binding16990798
GO:0070577IDA-lysine-acetylated histone binding19187761
GO ID Evidence Qualifier GO_term References
GO:0006306IEA-DNA methylation-
GO:0006366TAS-transcription from RNA polymerase II promoter10821850
GO:0006461IDA-protein complex assembly15199122
GO:0006915IEA-apoptotic process-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0008542IEA-visual learning-
GO:0009791IEA-post-embryonic development-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0018026IEA-peptidyl-lysine monomethylation-
GO:0032411IMP-positive regulation of transporter activity20861184
GO:0032922ISS-circadian regulation of gene expression-
GO:0035162TAS-embryonic hemopoiesis15618964
GO:0035640IEA-exploration behavior-
GO:0035864IEA-response to potassium ion-
GO:0043984IMP-histone H4-K16 acetylation15960975
GO:0044648IEA-histone H3-K4 dimethylation-
GO:0045893IMP-positive regulation of transcription, DNA-templated15960975
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter20861184
GO:0048172IEA-regulation of short-term neuronal synaptic plasticity-
GO:0048536IEA-spleen development-
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0051568IDA-histone H3-K4 methylation19556245
GO:0051568IMP-histone H3-K4 methylation15960975
GO:0051571ISS-positive regulation of histone H3-K4 methylation-
GO:0051899IEA-membrane depolarization-
GO:0060216IEA-definitive hemopoiesis-
GO:0071440ISS-regulation of histone H3-K14 acetylation-
GO:0080182IDA-histone H3-K4 trimethylation20861184
GO:1901674IEA-regulation of histone H3-K27 acetylation-
GO:2000615ISS-regulation of histone H3-K9 acetylation-
GO:2001040IMP-positive regulation of cellular response to drug20861184
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MLLAVP11044314607844 Biochemical Activity
MLLAVP10703214607844 Biochemical Activity
MLLBMI111044312829790 Reconstituted Complex
MLLBMI110711612829790 Reconstituted Complex
MLLCREBBP11044311259575 12205094 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MLLCREBBP10777711259575 12205094 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
MLLCTBP111044312829790 Affinity Capture-Western; Reconstituted Complex
MLLCTBP110786912829790 Affinity Capture-Western; Reconstituted Complex
MLLCTNNB111044316510874 16510875 Affinity Capture-MS; Reconstituted Complex
MLLCTNNB110788016510874 16510875 Affinity Capture-MS; Reconstituted Complex
MLLE2F211044316951254 Affinity Capture-Western
MLLE2F210820216951254 Affinity Capture-Western
MLLE2F411044316951254 Affinity Capture-Western
MLLE2F410820616951254 Affinity Capture-Western
MLLE2F610820816951254 Affinity Capture-Western
MLLE2F611044316951254 Affinity Capture-Western
MLLHCFC111044315199122 Affinity Capture-Western; Co-purification
MLLHCFC110930415199122 Affinity Capture-Western; Co-purification
MLLHDAC110931512829790 Affinity Capture-Western; Reconstituted Complex
MLLHDAC111044312829790 Affinity Capture-Western; Reconstituted Complex
MLLINS10984214607844 Biochemical Activity
MLLINS11044314607844 Biochemical Activity
MLLMAP3K511044314607843 Affinity Capture-Western
MLLMAP3K511038114607843 Affinity Capture-Western
MLLMEN111044315199122 16199523 16239140 16618927 17671196 19818711 20064463 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
MLLMEN111038415199122 16199523 16239140 16618927 17671196 19818711 20064463 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
SETMLL1104439353299 Reconstituted Complex; Two-hybrid
SETMLL1123169353299 Reconstituted Complex; Two-hybrid
MTM1MLL1104439537414 Reconstituted Complex
MTM1MLL1106309537414 Reconstituted Complex
SBF1MLL1104439537414 Reconstituted Complex
SBF1MLL1122129537414 Reconstituted Complex
SMARCB1MLL11248210490642 Affinity Capture-Western
SMARCB1MLL11044310490642 Affinity Capture-Western
PPP1R15AMLL11717210490642 Affinity Capture-Western; Two-hybrid
PPP1R15AMLL11044310490642 Affinity Capture-Western; Two-hybrid
MLLMLL11044311313484 12393701 12482972 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPIEMLL11571411313484 18676843 Affinity Capture-Western; Two-hybrid
PPIEMLL11044311313484 18676843 Affinity Capture-Western; Two-hybrid
CBX4MLL11044312829790 Reconstituted Complex
CBX4MLL11410512829790 Reconstituted Complex
OXTMLL11106014607844 Biochemical Activity
OXTMLL11044314607844 Biochemical Activity
RBBP5MLL11044315199122 15960975 20064463 Affinity Capture-Western; Co-localization; Co-purification
RBBP5MLL11186415199122 15960975 20064463 Affinity Capture-Western; Co-localization; Co-purification
ASH2LMLL11044315199122 20064463 Affinity Capture-Western; Co-localization; Co-purification
ASH2LMLL11452815199122 20064463 Affinity Capture-Western; Co-localization; Co-purification
HCFC2MLL11895915199122 Affinity Capture-Western; Co-purification
HCFC2MLL11044315199122 Affinity Capture-Western; Co-purification
WDR5MLL11044315199122 18840606 Affinity Capture-Western; Co-purification; Reconstituted Complex
WDR5MLL11627215199122 18840606 Affinity Capture-Western; Co-purification; Reconstituted Complex
RNF2MLL11197215960975 Affinity Capture-Western
RNF2MLL11044315960975 Affinity Capture-Western
MYST1MLL11044315960975 Affinity Capture-Western
MYST1MLL12391415960975 Affinity Capture-Western
TP53MLL11044315960975 Reconstituted Complex
TP53MLL11301015960975 Reconstituted Complex
POLR2AMLL11044316199523 Affinity Capture-Western; Co-localization; Reconstituted Complex
POLR2AMLL11142616199523 Affinity Capture-Western; Co-localization; Reconstituted Complex
MLLT4MLL11044316239140 Affinity Capture-Western
MLLT4MLL11044716239140 Affinity Capture-Western
CXXC1MLL11904518082152 Affinity Capture-Western
CXXC1MLL11044318082152 Affinity Capture-Western
PSIP1MLL11044318598942 Affinity Capture-Western
PSIP1MLL11633918598942 Affinity Capture-Western
SNW1MLL11044319818711 Affinity Capture-Western
SNW1MLL11659719818711 Affinity Capture-Western
MYBMLL11068720093773 Affinity Capture-Western
MYBMLL11044320093773 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96995
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080521-3'