AutismKB 2.0

Annotation Details for MLLT4


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Basic Information Top
Gene Symbol:MLLT4 ( AF6,FLJ34371,RP3-431P23.3 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Band: 6q27
Quick LinksEntrez ID:4301; OMIM: 159559; Uniprot ID:Q59FP0_HUMAN; ENSEMBL ID: ENSG00000130396,ENSG00000249273; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005911IEA-cell-cell junction-
GO:0005912IEA-adherens junction-
GO:0016607IDA-nuclear speck-
GO:0030054IDA-cell junction-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding17491594
GO:0008022TAS-protein C-terminus binding10856295
GO:0017016IDA-Ras GTPase binding23885123
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0007155IEA-cell adhesion-
GO:0007165IEA-signal transduction-
GO:0007267TAS-cell-cell signaling8242616
GO:0032880IBA-regulation of protein localization-
GO:0034332IBA-adherens junction organization-
GO:0034332TAS-adherens junction organization-
GO:0043547IMP-positive regulation of GTPase activity23885123
GO:0090557IMP-establishment of endothelial intestinal barrier23885123
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MLLT4JAG11104479707552 Two-hybrid
MLLT4JAG11066899707552 Two-hybrid
MLLT4BCR11044712808105 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MLLT4BCR10708312808105 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MLLT4CTNNA111044711907041 Reconstituted Complex
MLLT4CTNNA110787611907041 Reconstituted Complex
MLLT4EPHA71104479707552 Two-hybrid
MLLT4EPHA71083599707552 Two-hybrid
MLLT4EPHB21104479707552 Two-hybrid
MLLT4EPHB21083629707552 Two-hybrid
MLLT4EPHB31104479707552 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MLLT4EPHB31083639707552 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MLLT4EPHB61104479707552 Two-hybrid
MLLT4EPHB61083659707552 Two-hybrid
MLLT4HRAS10950110334923 10922060 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MLLT4HRAS11044710334923 10922060 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MLLT4LMO211019112067721 Affinity Capture-Western; Reconstituted Complex
MLLT4LMO211044712067721 Affinity Capture-Western; Reconstituted Complex
MLLT4MEN111038416239140 Affinity Capture-Western
MLLT4MEN111044716239140 Affinity Capture-Western
MLLT4MLL11044316239140 Affinity Capture-Western
MLLT4MLL11044716239140 Affinity Capture-Western
NRXN3MLLT41147709707552 Two-hybrid
NRXN3MLLT41104479707552 Two-hybrid
NRXN1MLLT41147799707552 Two-hybrid
NRXN1MLLT41104479707552 Two-hybrid
NRXN2MLLT41104479707552 Two-hybrid
NRXN2MLLT41147809707552 Two-hybrid
USP9XMLLT41138679722616 10620020 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
USP9XMLLT41104479722616 10620020 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SORBS1MLLT411044710085297 Affinity Capture-Western; Reconstituted Complex
SORBS1MLLT411583110085297 Affinity Capture-Western; Reconstituted Complex
PVRL1MLLT411177610225955 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
PVRL1MLLT411044710225955 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
TJP1MLLT411293710334923 Affinity Capture-Western; Reconstituted Complex
TJP1MLLT411044710334923 Affinity Capture-Western; Reconstituted Complex
SORBS2MLLT411044710521485 Reconstituted Complex
SORBS2MLLT411404710521485 Reconstituted Complex
RIT1MLLT411044710545207 Two-hybrid
RIT1MLLT411194810545207 Two-hybrid
RIN1MLLT411497210545207 Two-hybrid
RIN1MLLT411044710545207 Two-hybrid
PVRL2MLLT411177710617658 Affinity Capture-Western
PVRL2MLLT411044710617658 Affinity Capture-Western
PVRL3MLLT411744110744716 11024295 Reconstituted Complex
PVRL3MLLT411044710744716 11024295 Reconstituted Complex
F11RMLLT411915310856295 Affinity Capture-Western; Reconstituted Complex
F11RMLLT411044710856295 Affinity Capture-Western; Reconstituted Complex
PFN1MLLT411123710922060 Reconstituted Complex; Two-hybrid
PFN1MLLT411044710922060 Reconstituted Complex; Two-hybrid
RAP1AMLLT411044710922060 Reconstituted Complex; Two-hybrid
RAP1AMLLT411184110922060 Reconstituted Complex; Two-hybrid
RRAS2MLLT411648011788587 Two-hybrid
RRAS2MLLT411044711788587 Two-hybrid
SSX2IPMLLT411044712446711 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SSX2IPMLLT412556712446711 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAP1GAPMLLT411044712590145 Affinity Capture-Western; Two-hybrid
RAP1GAPMLLT411184412590145 Affinity Capture-Western; Two-hybrid
NRASMLLT411095212808105 Affinity Capture-Western
NRASMLLT411044712808105 Affinity Capture-Western
YWHAQMLLT411616817353931 Affinity Capture-MS
YWHAQMLLT411044717353931 Affinity Capture-MS
YWHABMLLT411336117353931 Affinity Capture-MS
YWHABMLLT411044717353931 Affinity Capture-MS
YWHAGMLLT411336417353931 Affinity Capture-MS
YWHAGMLLT411044717353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1314653
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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