Annotation Details for MME

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	MME ( CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP )
Gene Full Name:	membrane metallo-endopeptidase
Band:	3q25.2
Quick Links	Entrez ID:4311; OMIM: 120520; Uniprot ID:NEP_HUMAN; ENSEMBL ID: ENSG00000196549; HGNC ID: 7154
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:14 results
Molecular Function:9 results
Biological Process:12 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005737	IDA	-	cytoplasm	20876573
GO:0005886	IDA	-	plasma membrane	20876573
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	NAS	-	integral component of plasma membrane	2521388
GO:0005903	IDA	-	brush border	22272689
GO:0005925	IDA	-	focal adhesion	21423176
GO:0008021	ISS	-	synaptic vesicle	-
GO:0016021	NAS	-	integral component of membrane	2968607
GO:0030424	ISS	-	axon	-
GO:0030425	ISS	-	dendrite	-
GO:0030667	TAS	-	secretory granule membrane	-
GO:0044306	ISS	-	neuron projection terminus	-
GO:0045202	ISS	-	synapse	-
GO:0070062	IDA	-	extracellular exosome	19056867

GO ID	Evidence	Qualifier	GO_term	References
GO:0004175	IDA	-	endopeptidase activity	8168535
GO:0004175	IMP	-	endopeptidase activity	2531377
GO:0004222	IDA	-	metalloendopeptidase activity	15283675
GO:0004222	IMP	-	metalloendopeptidase activity	2521388
GO:0005515	IPI	-	protein binding	17342744
GO:0008237	EXP	-	metallopeptidase activity	15283675
GO:0008238	IDA	-	exopeptidase activity	6208535
GO:0008270	IDA	-	zinc ion binding	8168535
GO:0042277	ISS	-	peptide binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001822	IEP	-	kidney development	22272689
GO:0002003	TAS	-	angiotensin maturation	-
GO:0006508	IDA	-	proteolysis	8168535
GO:0006518	ISS	-	peptide metabolic process	-
GO:0019233	ISS	-	sensory perception of pain	-
GO:0043312	TAS	-	neutrophil degranulation	-
GO:0046449	IMP	-	creatinine metabolic process	22024547
GO:0050435	ISS	-	amyloid-beta metabolic process	-
GO:0071345	IDA	-	cellular response to cytokine stimulus	20876573
GO:0071492	IDA	-	cellular response to UV-A	20876573
GO:0071493	IDA	-	cellular response to UV-B	20876573
GO:0090399	IEP	-	replicative senescence	20876573

Protein-Protein Interaction

BioGRID:4 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
MME	CSNK2A1	107841	8943850	Biochemical Activity
MME	CSNK2A1	110455	8943850	Biochemical Activity
MME	LYN	110245	8943850	Affinity Capture-Western
MME	LYN	110455	8943850	Affinity Capture-Western

AlzGene, PDGene and SZGene

Alz Gene:1 results
PD Gene:0 results
SZ Gene:0 results

Gene Symbol	Poly Names	Gene overview in AlzGene
MME	IVS10-5C, IVS15+144, IVS17-294, IVS22+36, IVS3+106, MME_204, c401, rs1025192, rs10513467, rs10622201, rs11925306, rs13077421, rs13081581, rs1385477, rs16846960, rs1816558, rs1836915, rs2196521, rs34745881, rs35994024, rs3736187, rs3773882, rs3773885, rs3773906, rs3773907, rs4432598, rs5853711, rs6776185, rs6801319, rs701109, rs7623854, rs9834487, rs9853221, rs9881879, rs989692	Gene overview in AlzGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:97004
Data Attributes: MGI curated and HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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