AutismKB 2.0

Annotation Details for MMP9


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Basic Information Top
Gene Symbol:MMP9 ( CLG4B,GELB,MANDP2,MMP-9 )
Gene Full Name: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Band: 20q13.12
Quick LinksEntrez ID:4318; OMIM: 120361; Uniprot ID:MMP9_HUMAN; ENSEMBL ID: ENSG00000100985; HGNC ID: 7176
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005578IEA-proteinaceous extracellular matrix-
GO:0005615IDA-extracellular space2551898
GO:0070062IDA-extracellular exosome23376485
GO:1904724TAS-tertiary granule lumen-
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004175EXP-endopeptidase activity9256427
GO:0004175IDA-endopeptidase activity19022250
GO:0004222IDA-metalloendopeptidase activity2551898
GO:0004222TAS-metalloendopeptidase activity-
GO:0004252EXP-serine-type endopeptidase activity17428795
GO:0004252TAS-serine-type endopeptidase activity-
GO:0005515IPI-protein binding2251898
GO:0005518TAS-collagen binding2551898
GO:0008237IDA-metallopeptidase activity24236012
GO:0008270TAS-zinc ion binding2551898
GO:0042802IPI-identical protein binding23601700
GO ID Evidence Qualifier GO_term References
GO:0001501IEA-skeletal system development-
GO:0001503IEA-ossification-
GO:0001934IMP-positive regulation of protein phosphorylation22984561
GO:0006508IDA-proteolysis2551898
GO:0007566IEA-embryo implantation-
GO:0022617TAS-extracellular matrix disassembly-
GO:0030225TAS-macrophage differentiation2551898
GO:0030335TAS-positive regulation of cell migration23675531
GO:0030574TAS-collagen catabolic process-
GO:0034614IDA-cellular response to reactive oxygen species26514923
GO:0035987IEP-endodermal cell differentiation23154389
GO:0043066IMP-negative regulation of apoptotic process22984561
GO:0043312TAS-neutrophil degranulation-
GO:0043388IDA-positive regulation of DNA binding22984561
GO:0045742IMP-positive regulation of epidermal growth factor receptor signaling pathway22984561
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0050900IEA-leukocyte migration-
GO:0051549IMP-positive regulation of keratinocyte migration17704059
GO:0071276IDA-cellular response to cadmium ion26514923
GO:0090200IMP-positive regulation of release of cytochrome c from mitochondria22984561
GO:1900122IDA-positive regulation of receptor binding24164424
GO:1904707IMP-positive regulation of vascular smooth muscle cell proliferation18667463
GO:2001243IMP-negative regulation of intrinsic apoptotic signaling pathway22984561
GO:2001258IDA-negative regulation of cation channel activity24164424
GO:2001268IMP-negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway22984561
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TGFB1MMP911046110652271 Biochemical Activity
TGFB1MMP911289810652271 Biochemical Activity
THBS1MMP911291510900205 Affinity Capture-Western
THBS1MMP911046110900205 Affinity Capture-Western
THBS2MMP911046110900205 Affinity Capture-Western
THBS2MMP911291610900205 Affinity Capture-Western
CXCL6MMP911227412950257 Biochemical Activity
CXCL6MMP911046112950257 Biochemical Activity
CXCL5MMP911227612950257 Biochemical Activity
CXCL5MMP911046112950257 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
MMP9rs2250889, rs2274756, rs2664538, rs3918242 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
MMP9rs3918242 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97011
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2132'