AutismKB 2.0

Annotation Details for MRE11A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MRE11A ( ATLD,HNGS1,MRE11,MRE11B )
Gene Full Name: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Band: 11q21
Quick LinksEntrez ID:4361; OMIM: 600814; Uniprot ID:MRE11_HUMAN; ENSEMBL ID: ENSG00000020922; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000781IDAcolocalizes_withchromosome, telomeric region15149599
GO:0000784IDA-nuclear chromosome, telomeric region10811102
GO:0000784IDAcolocalizes_withnuclear chromosome, telomeric region24270157
GO:0000784ISScolocalizes_withnuclear chromosome, telomeric region-
GO:0005634TAS-nucleus10802669
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm25468996
GO:0005829TAS-cytosol-
GO:0016605IDA-PML body10811102
GO:0016605ISS-PML body-
GO:0030870IDA-Mre11 complex19151086
GO:0030870NAS-Mre11 complex15790808
GO:0030870TAS-Mre11 complex27918544
GO:0035861IDA-site of double-strand break15916964
GO ID Evidence Qualifier GO_term References
GO:0000014IDA-single-stranded DNA endodeoxyribonuclease activity9705271
GO:0003677IDAcontributes_toDNA binding15790808
GO:0003690TAS-double-stranded DNA binding10802669
GO:0004003IMPcontributes_toATP-dependent DNA helicase activity15790808
GO:0004518TAS-nuclease activity15790808
GO:0004520IDA-endodeoxyribonuclease activity9705271
GO:0004520TAS-endodeoxyribonuclease activity-
GO:0005515IPI-protein binding12419185
GO:0008022IPI-protein C-terminus binding9590181
GO:0008408IDA-3'-5' exonuclease activity9651580
GO:0030145IEA-manganese ion binding-
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0000019TAS-regulation of mitotic recombination8530104
GO:0000724TAS-double-strand break repair via homologous recombination-
GO:0000729TAS-DNA double-strand break processing-
GO:0000731TAS-DNA synthesis involved in DNA repair-
GO:0000732TAS-strand displacement-
GO:0006260TAS-DNA replication-
GO:0006281TAS-DNA repair9705271
GO:0006302TAS-double-strand break repair10612394
GO:0006303IDA-double-strand break repair via nonhomologous end joining9651580
GO:0006303TAS-double-strand break repair via nonhomologous end joining-
GO:0006310TAS-DNA recombination9705271
GO:0006974IDA-cellular response to DNA damage stimulus17500065
GO:0007004TAS-telomere maintenance via telomerase9705271
GO:0007062IMP-sister chromatid cohesion15917200
GO:0007095IEA-mitotic G2 DNA damage checkpoint-
GO:0007129IEA-synapsis-
GO:0007131TAS-reciprocal meiotic recombination8530104
GO:0008283IEA-cell proliferation-
GO:0016032IEA-viral process-
GO:0031573IBA-intra-S DNA damage checkpoint-
GO:0031860IMP-telomeric 3' overhang formation16374507
GO:0031954IDA-positive regulation of protein autophosphorylation15790808
GO:0032206IMP-positive regulation of telomere maintenance16374507
GO:0032481TAS-positive regulation of type I interferon production-
GO:0032508IMP-DNA duplex unwinding15790808
GO:0032876IMP-negative regulation of DNA endoreduplication15917200
GO:0033674IDA-positive regulation of kinase activity15790808
GO:0043066IMP-negative regulation of apoptotic process16374507
GO:0090305IEA-nucleic acid phosphodiester bond hydrolysis-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MRE11AATM11050110608806 10783165 Co-purification; Protein-peptide
MRE11AATM10696210608806 10783165 Co-purification; Protein-peptide
MRE11AATR10702710608806 Protein-peptide
MRE11AATR11050110608806 Protein-peptide
MRE11ABLM10711010783165 Co-purification
MRE11ABLM11050110783165 Co-purification
MRE11ABRCA110714010426999 10783165 11353843 11504724 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
MRE11ABRCA111050110426999 10783165 11353843 11504724 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
MRE11AATF210777615916964 Co-localization
MRE11AATF211050115916964 Co-localization
MRE11ADDX110801918710941 Affinity Capture-Western
MRE11ADDX111050118710941 Affinity Capture-Western
MRE11AXRCC610882210508516 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MRE11AXRCC611050110508516 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MRE11AMSH610921110783165 Co-purification
MRE11AMSH611050110783165 Co-purification
MRE11AH2AFX10926815201865 Affinity Capture-Western
MRE11AH2AFX11050115201865 Affinity Capture-Western
MRE11APRMT110951218285453 Affinity Capture-Western
MRE11APRMT111050118285453 Affinity Capture-Western
MRE11ALIG11101668530104 Two-hybrid
MRE11ALIG11105018530104 Two-hybrid
MRE11AMLH111043810783165 Co-purification
MRE11AMLH111050110783165 Co-purification
RAD50MRE11A1105018756642 9705271 10508516 10783165 11504724 12607003 17500065 19270065 Affinity Capture-MS; Affinity Capture-Western; Co-purification
RAD50MRE11A1154178756642 9705271 10508516 10783165 11504724 12607003 17500065 19270065 Affinity Capture-MS; Affinity Capture-Western; Co-purification
NBNMRE11A1107639705271 10783165 11238951 12607003 12679336 17500065 18458108 19270065 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Two-hybrid
NBNMRE11A1105019705271 10783165 11238951 12607003 12679336 17500065 18458108 19270065 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Two-hybrid
PRKDCMRE11A11157710608806 Protein-peptide
PRKDCMRE11A11050110608806 Protein-peptide
MSH2MRE11A11057310783165 Co-purification
MSH2MRE11A11050110783165 Co-purification
RFC1MRE11A11191310783165 Co-purification
RFC1MRE11A11050110783165 Co-purification
TERF2MRE11A11287310888888 18212065 Affinity Capture-Western
TERF2MRE11A11050110888888 18212065 Affinity Capture-Western
MDC1MRE11A11501412607003 14519663 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
MDC1MRE11A11050112607003 14519663 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TERF2IPMRE11A11994215100233 Affinity Capture-MS
TERF2IPMRE11A11050115100233 Affinity Capture-MS
PAXIP1MRE11A11050117500065 Affinity Capture-MS; Affinity Capture-Western
PAXIP1MRE11A11662517500065 Affinity Capture-MS; Affinity Capture-Western
NLRP2MRE11A12078718285453 Affinity Capture-Western
NLRP2MRE11A11050118285453 Affinity Capture-Western
RECQL5MRE11A11479719270065 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RECQL5MRE11A11050119270065 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SUMO2MRE11A11249719394292 Affinity Capture-MS
SUMO2MRE11A11050119394292 Affinity Capture-MS
USP11MRE11A11386619615732 Affinity Capture-MS
USP11MRE11A11050119615732 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
TP53MRE11A30097415806145 Mre11 interacts with p53. This interaction was modeled on a demonstrated interaction between Mre11 and p53 both from African green monkey.
NBNMRE11A25869615758953 NBS1 interacts with MRE11A (Mre11).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1100512
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2638'