AutismKB 2.0

Annotation Details for MSH2


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Basic Information Top
Gene Symbol:MSH2 ( COCA1,FCC1,HNPCC,HNPCC1,LCFS2 )
Gene Full Name: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Band: 2p21-p16.3
Quick LinksEntrez ID:4436; OMIM: 609309; Uniprot ID:MSH2_HUMAN; ENSEMBL ID: ENSG00000095002; HGNC ID: 7325
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IDA-nuclear chromosome, telomeric region19135898
GO:0005654TAS-nucleoplasm-
GO:0016020IDA-membrane19946888
GO:0032301IDA-MutSalpha complex8942985
GO:0032302IDA-MutSbeta complex8942985
GO ID Evidence Qualifier GO_term References
GO:0000287IDAcontributes_tomagnesium ion binding16403449
GO:0000400IDAcontributes_tofour-way junction DNA binding12034830
GO:0003677IDA-DNA binding7923193
GO:0003690IDAcontributes_todouble-stranded DNA binding11809883
GO:0003697IDAcontributes_tosingle-stranded DNA binding11809883
GO:0005515IPI-protein binding8942985
GO:0005515IPIcontributes_toprotein binding16403449
GO:0005524IDAcontributes_toATP binding15105434
GO:0008022IPI-protein C-terminus binding14706347
GO:0016887IDAcontributes_toATPase activity16403449
GO:0019237IEA-centromeric DNA binding-
GO:0019899IPI-enzyme binding9788596
GO:0019901IPI-protein kinase binding14657349
GO:0030983IDAcontributes_tomismatched DNA binding8942985
GO:0032137IDAcontributes_toguanine/thymine mispair binding8942985
GO:0032137IMP-guanine/thymine mispair binding16713580
GO:0032139IDAcontributes_todinucleotide insertion or deletion binding8942985
GO:0032142IDAcontributes_tosingle guanine insertion binding8942985
GO:0032143IDAcontributes_tosingle thymine insertion binding8942985
GO:0032181IDAcontributes_todinucleotide repeat insertion binding8942985
GO:0032357IDAcontributes_tooxidized purine DNA binding11756455
GO:0032405IDAcontributes_toMutLalpha complex binding16403449
GO:0042803IDA-protein homodimerization activity8942985
GO:0043531IDAcontributes_toADP binding15105434
GO ID Evidence Qualifier GO_term References
GO:0001701IEA-in utero embryonic development-
GO:0006119IEA-oxidative phosphorylation-
GO:0006281IDA-DNA repair8942985
GO:0006298IDA-mismatch repair7923193
GO:0006298IGI-mismatch repair23603115
GO:0006298TAS-mismatch repair-
GO:0006301IDA-postreplication repair7923193
GO:0006302IEA-double-strand break repair-
GO:0007050IEA-cell cycle arrest-
GO:0007281IEA-germ cell development-
GO:0008340IEA-determination of adult lifespan-
GO:0008584ISS-male gonad development-
GO:0010165ISS-response to X-ray-
GO:0010224ISS-response to UV-B-
GO:0016446IEA-somatic hypermutation of immunoglobulin genes-
GO:0016447ISS-somatic recombination of immunoglobulin gene segments-
GO:0019724ISS-B cell mediated immunity-
GO:0030183ISS-B cell differentiation-
GO:0031573IEA-intra-S DNA damage checkpoint-
GO:0042771IEA-intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-
GO:0043524ISS-negative regulation of neuron apoptotic process-
GO:0043570IMP-maintenance of DNA repeat elements16388310
GO:0045190ISS-isotype switching-
GO:0045910IDA-negative regulation of DNA recombination17715146
GO:0045910ISS-negative regulation of DNA recombination-
GO:0048298IEA-positive regulation of isotype switching to IgA isotypes-
GO:0048304IEA-positive regulation of isotype switching to IgG isotypes-
GO:0051096IDA-positive regulation of helicase activity17715146
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MSH2AIRE11057320085707 Affinity Capture-MS
MSH2AIRE10682320085707 Affinity Capture-MS
MSH2ATM11057310783165 Co-purification
MSH2ATM10696210783165 Co-purification
MSH2ATR11057314657349 21285353 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex
MSH2ATR10702714657349 21285353 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex
MSH2BARD111057311498787 Reconstituted Complex
MSH2BARD110705611498787 Reconstituted Complex
MSH2BLM11057310783165 Co-purification
MSH2BLM10711010783165 Co-purification
MSH2BRCA111057310783165 11498787 15886699 16260778 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
MSH2BRCA110714010783165 11498787 15886699 16260778 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
MSH2CHEK111057315647386 Affinity Capture-Western
MSH2CHEK110753615647386 Affinity Capture-Western
MSH2ESR111057315886699 16260778 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
MSH2ESR110840315886699 16260778 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
MSH2ESR211057315886699 Affinity Capture-Western; Reconstituted Complex
MSH2ESR210840415886699 Affinity Capture-Western; Reconstituted Complex
MSH2KAT2A11057316260778 Affinity Capture-Western
MSH2KAT2A10891816260778 Affinity Capture-Western
MSH2MSH61105738942985 9774676 10029069 10783165 14657349 Affinity Capture-MS; Co-purification; Reconstituted Complex
MSH2MSH61092118942985 9774676 10029069 10783165 14657349 Affinity Capture-MS; Co-purification; Reconstituted Complex
MSH2MAX11057312584560 Affinity Capture-Western; Reconstituted Complex
MSH2MAX11031912584560 Affinity Capture-Western; Reconstituted Complex
MSH2MGMT11057316226712 Affinity Capture-MS
MSH2MGMT11041116226712 Affinity Capture-MS
MSH2MLH111057310783165 Co-purification
MSH2MLH111043810783165 Co-purification
MSH2MRE11A11057310783165 Co-purification
MSH2MRE11A11050110783165 Co-purification
MSH3MSH21105738942985 9774676 10029069 14657349 Affinity Capture-MS; Reconstituted Complex
MSH3MSH21105748942985 9774676 10029069 14657349 Affinity Capture-MS; Reconstituted Complex
MSH2MSH21105738942985 Reconstituted Complex
EXO1MSH21146029788596 10856833 11427529 19015241 Reconstituted Complex; Two-hybrid
EXO1MSH21105739788596 10856833 11427529 19015241 Reconstituted Complex; Two-hybrid
RAD50MSH211541710783165 Co-purification
RAD50MSH211057310783165 Co-purification
NBNMSH211057310783165 Co-purification
NBNMSH211076310783165 Co-purification
RFC1MSH211057310783165 Co-purification
RFC1MSH211191310783165 Co-purification
TP53MSH211301012101417 Affinity Capture-Western
TP53MSH211057312101417 Affinity Capture-Western
PCNAMSH211057312171929 Affinity Capture-MS
PCNAMSH211114212171929 Affinity Capture-MS
CHEK2MSH211636912447371 15647386 Affinity Capture-Western; Reconstituted Complex
CHEK2MSH211057312447371 15647386 Affinity Capture-Western; Reconstituted Complex
MYCMSH211057312584560 Affinity Capture-Western
MYCMSH211069412584560 Affinity Capture-Western
ATRIPMSH231346314657349 Affinity Capture-Western
ATRIPMSH211057314657349 Affinity Capture-Western
PRKCZMSH211057315808853 Affinity Capture-Western
PRKCZMSH211157615808853 Affinity Capture-Western
UBCMSH211316415808853 Affinity Capture-Western
UBCMSH211057315808853 Affinity Capture-Western
PMS2MSH211057317148452 Affinity Capture-MS
PMS2MSH211140417148452 Affinity Capture-MS
PTP4A3MSH211632717353931 Affinity Capture-MS
PTP4A3MSH211057317353931 Affinity Capture-MS
SUMO2MSH211249719394292 Affinity Capture-MS
SUMO2MSH211057319394292 Affinity Capture-MS
RPA4MSH211897519468048 Reconstituted Complex
RPA4MSH211057319468048 Reconstituted Complex
XPAMSH211334419468048 Reconstituted Complex
XPAMSH211057319468048 Reconstituted Complex
SLX4MSH212409719596235 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
SLX4MSH211057319596235 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
OTUB1MSH212075119615732 Affinity Capture-MS
OTUB1MSH211057319615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:101816
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2932'