Annotation Details for MSH4

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Basic Information Top

Gene Symbol:	MSH4 ( - )
Gene Full Name:	mutS homolog 4 (E. coli)
Band:	1p31.1
Quick Links	Entrez ID:4438; OMIM: 602105; Uniprot ID:MSH4_HUMAN; ENSEMBL ID: ENSG00000057468; HGNC ID: 7327
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:3 results
Molecular Function:4 results
Biological Process:6 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0000795	IEA	-	synaptonemal complex	-
GO:0005634	TAS	-	nucleus	9299235
GO:0005713	IEA	-	recombination nodule	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003677	TAS	-	DNA binding	9299235
GO:0005515	IPI	-	protein binding	16397227
GO:0005524	IEA	-	ATP binding	-
GO:0030983	IEA	-	mismatched DNA binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001541	IEA	-	ovarian follicle development	-
GO:0006298	IEA	-	mismatch repair	-
GO:0007129	IEA	-	synapsis	-
GO:0007131	TAS	-	reciprocal meiotic recombination	9299235
GO:0007283	IEA	-	spermatogenesis	-
GO:0007292	IEA	-	female gamete generation	-

Protein-Protein Interaction

BioGRID:12 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
MSH4	MLH1	110438	10928988	Affinity Capture-Western; Reconstituted Complex
MSH4	MLH1	110575	10928988	Affinity Capture-Western; Reconstituted Complex
MSH5	MSH4	110575	9787078 10029069 12591739	Reconstituted Complex; Two-hybrid
MSH5	MSH4	110576	9787078 10029069 12591739	Reconstituted Complex; Two-hybrid
RAD51	MSH4	111825	11950880	Co-localization
RAD51	MSH4	110575	11950880	Co-localization
RPA1	MSH4	110575	11950880	Co-localization
RPA1	MSH4	112037	11950880	Co-localization
MLH3	MSH4	117961	12095912	Affinity Capture-Western; Reconstituted Complex
MLH3	MSH4	110575	12095912	Affinity Capture-Western; Reconstituted Complex
VBP1	MSH4	113254	12591739	Reconstituted Complex; Two-hybrid
VBP1	MSH4	110575	12591739	Reconstituted Complex; Two-hybrid

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:1860077
Data Attributes: MGI curated and HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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