AutismKB 2.0

Annotation Details for MSX1


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Basic Information Top
Gene Symbol:MSX1 ( HOX7,HYD1,STHAG1 )
Gene Full Name: msh homeobox 1
Band: 4p16.2
Quick LinksEntrez ID:4487; OMIM: 142983; Uniprot ID:MSX1_HUMAN; ENSEMBL ID: ENSG00000163132; HGNC ID: 7391
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus15705871
GO:0005654IDA-nucleoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000977IEA-RNA polymerase II regulatory region sequence-specific DNA binding-
GO:0000982IEA-transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001227IEA-transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0001228IEA-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0002039IPI-p53 binding15705871
GO:0035326IEA-enhancer binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0000902IDA-cell morphogenesis15705871
GO:0001701IEA-in utero embryonic development-
GO:0003198IEA-epithelial to mesenchymal transition involved in endocardial cushion formation-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007517IEA-muscle organ development-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0010463IEA-mesenchymal cell proliferation-
GO:0021983IEA-pituitary gland development-
GO:0023019IEA-signal transduction involved in regulation of gene expression-
GO:0030308IDA-negative regulation of cell growth15705871
GO:0030513IEA-positive regulation of BMP signaling pathway-
GO:0030901IEA-midbrain development-
GO:0034504IDA-protein localization to nucleus15705871
GO:0035115IEA-embryonic forelimb morphogenesis-
GO:0035116IEA-embryonic hindlimb morphogenesis-
GO:0035880IMP-embryonic nail plate morphogenesis11369996
GO:0042474IEA-middle ear morphogenesis-
GO:0042475IMP-odontogenesis of dentin-containing tooth8696335
GO:0042481IEA-regulation of odontogenesis-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043517IC-positive regulation of DNA damage response, signal transduction by p53 class mediator15705871
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048863IEA-stem cell differentiation-
GO:0050821IDA-protein stabilization15705871
GO:0051154IEA-negative regulation of striated muscle cell differentiation-
GO:0060021IEA-palate development-
GO:0060325IMP-face morphogenesis10742093
GO:0060349IEA-bone morphogenesis-
GO:0060536IEA-cartilage morphogenesis-
GO:0061180IEA-mammary gland epithelium development-
GO:0061312IEA-BMP signaling pathway involved in heart development-
GO:0071316IEA-cellular response to nicotine-
GO:0090427IEA-activation of meiosis-
GO:1902255IDA-positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator15705871
GO:2000678IEA-negative regulation of transcription regulatory region DNA binding-
GO:2001055IEA-positive regulation of mesenchymal cell apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MSX1CREBBP11059310215616 Affinity Capture-Western; Phenotypic Suppression
MSX1CREBBP10777710215616 Affinity Capture-Western; Phenotypic Suppression
MSX1DLX21080909111364 Reconstituted Complex; Two-hybrid
MSX1DLX21105939111364 Reconstituted Complex; Two-hybrid
MSX1DLX51080939111364 Reconstituted Complex
MSX1DLX51105939111364 Reconstituted Complex
MSX1HOXC81105939111364 Reconstituted Complex
MSX1HOXC81094649111364 Reconstituted Complex
TBPMSX11105938700832 9111364 10215616 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
TBPMSX11127718700832 9111364 10215616 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
MSX1MSX11105939111364 Reconstituted Complex; Two-hybrid
MSX2MSX11105939111364 Reconstituted Complex; Two-hybrid
MSX2MSX11105949111364 Reconstituted Complex; Two-hybrid
LHX2MSX11147589697309 Reconstituted Complex
LHX2MSX11105939697309 Reconstituted Complex
SP1MSX111059310215616 Affinity Capture-Western; Phenotypic Suppression
SP1MSX111255010215616 Affinity Capture-Western; Phenotypic Suppression
PAX3MSX111111110529415 Reconstituted Complex
PAX3MSX111059310529415 Reconstituted Complex
TLE2MSX111294420211142 Two-hybrid
TLE2MSX111059320211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97168
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-312'