AutismKB 2.0

Annotation Details for MT2A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MT2A ( MT2 )
Gene Full Name: metallothionein 2A
Band: 16q13
Quick LinksEntrez ID:4502; OMIM: 156360; Uniprot ID:MT2_HUMAN; ENSEMBL ID: ENSG00000125148; HGNC ID: 7406
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005737ISS-cytoplasm-
GO:0005829TAS-cytosol-
GO:0048471ISS-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding12646258
GO:0008144IDA-drug binding19536566
GO:0008270IDA-zinc ion binding19536566
GO:0008270ISS-zinc ion binding-
GO:0046870IEA-cadmium ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006878TAS-cellular copper ion homeostasis6719135
GO:0006882IEA-cellular zinc ion homeostasis-
GO:0007263IEA-nitric oxide mediated signal transduction-
GO:0010038TAS-response to metal ion-
GO:0010273IEA-detoxification of copper ion-
GO:0035690IDA-cellular response to drug19536566
GO:0036016IEP-cellular response to interleukin-311168427
GO:0036018IEP-cellular response to erythropoietin11168427
GO:0045926ISS-negative regulation of growth-
GO:0048143IEA-astrocyte activation-
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0071294IEP-cellular response to zinc ion11168427
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SPINK7MT2A12417412646258 12970870 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPINK7MT2A11060812646258 12970870 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRKD1MT2A11157314550308 Affinity Capture-Western; Two-hybrid
PRKD1MT2A11060814550308 Affinity Capture-Western; Two-hybrid
USP25MT2A11889516501887 Two-hybrid
USP25MT2A11060816501887 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
SPINK7MT2A29740112970870 ECRG2 interacts with MT2A.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97172
  • Data Attributes: MGI curated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018