AutismKB 2.0

Annotation Details for MYH9


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Basic Information Top
Gene Symbol:MYH9 ( DFNA17,EPSTS,FTNS,MGC104539,MHA,NMHC-II-A,NMMHCA )
Gene Full Name: myosin, heavy chain 9, non-muscle
Band: 22q12.3
Quick LinksEntrez ID:4627; OMIM: 160775; Uniprot ID:MYH9_HUMAN; ENSEMBL ID: ENSG00000100345; HGNC ID: 7579
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001725IDA-stress fiber7699007
GO:0001726IDA-ruffle16403913
GO:0001772IDAcolocalizes_withimmunological synapse15064761
GO:0001931IDA-uropod15064761
GO:0005634IDA-nucleus14508515
GO:0005737IDA-cytoplasm7699007
GO:0005819IEA-spindle-
GO:0005826IDA-actomyosin contractile ring11029059
GO:0005829IDA-cytosol14508515
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane16186248
GO:0005886IDAcolocalizes_withplasma membrane15064761
GO:0005903IEA-brush border-
GO:0005913IEA-cell-cell adherens junction-
GO:0005925ISScolocalizes_withfocal adhesion-
GO:0008180IDAcolocalizes_withCOP9 signalosome18850735
GO:0008305IDAcolocalizes_withintegrin complex10822899
GO:0015629IDA-actin cytoskeleton15869600
GO:0016020IDA-membrane19946888
GO:0016460IDA-myosin II complex24072716
GO:0031012IDA-extracellular matrix23979707
GO:0031252IDA-cell leading edge12421915
GO:0031594IEA-neuromuscular junction-
GO:0032154IDA-cleavage furrow7699007
GO:0042641IDA-actomyosin24072716
GO:0043234IDA-protein complex12421915
GO:0070062IDA-extracellular exosome19056867
GO:0097513IDA-myosin II filament24072716
GO ID Evidence Qualifier GO_term References
GO:0000146IDA-microfilament motor activity12237319
GO:0003723IDA-RNA binding22681889
GO:0003774NAS-motor activity12421915
GO:0003779IDA-actin binding15065866
GO:0005515IPI-protein binding10822899
GO:0005516IEA-calmodulin binding-
GO:0005524IDA-ATP binding15065866
GO:0016887IDA-ATPase activity12237319
GO:0019904IPI-protein domain specific binding23325791
GO:0030898IDA-actin-dependent ATPase activity15065866
GO:0030898IDAcontributes_toactin-dependent ATPase activity24072716
GO:0042803IDA-protein homodimerization activity12237319
GO:0043495IMP-protein anchor16403913
GO:0043531IDA-ADP binding15065866
GO:0045296IDA-cadherin binding25468996
GO:0051015IDA-actin filament binding12237319
GO:0051015IDAcontributes_toactin filament binding24072716
GO:0051015NAS-actin filament binding16403913
GO ID Evidence Qualifier GO_term References
GO:0000212IEA-meiotic spindle organization-
GO:0001525IDA-angiogenesis16403913
GO:0001701IEA-in utero embryonic development-
GO:0001768IEA-establishment of T cell polarity-
GO:0006509IDA-membrane protein ectodomain proteolysis16186248
GO:0006911ISS-phagocytosis, engulfment-
GO:0007229NAS-integrin-mediated signaling pathway10822899
GO:0007520IEA-myoblast fusion-
GO:0008360IMP-regulation of cell shape11029059
GO:0015031IMP-protein transport16403913
GO:0030048IDA-actin filament-based movement12237319
GO:0030220IMP-platelet formation12237319
GO:0030224IEP-monocyte differentiation1912569
GO:0031032IDA-actomyosin structure organization24072716
GO:0031532IMP-actin cytoskeleton reorganization15869600
GO:0032506IMP-cytokinetic process15774463
GO:0032796IEA-uropod organization-
GO:0043534IMP-blood vessel endothelial cell migration16403913
GO:0050900NAS-leukocyte migration12421915
GO:0051295IEA-establishment of meiotic spindle localization-
GO:0070527IMP-platelet aggregation23382103
GO:1903919IMP-negative regulation of actin filament severing23325791
GO:1903919ISS-negative regulation of actin filament severing-
GO:1903923ISS-positive regulation of protein processing in phagocytic vesicle-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MYH9EMD11071217620012 Affinity Capture-MS
MYH9EMD10832517620012 Affinity Capture-MS
MYH9EPB4110834917353931 Affinity Capture-MS
MYH9EPB4111071217353931 Affinity Capture-MS
MYH9GRB210914220936779 Two-hybrid
MYH9GRB211071220936779 Two-hybrid
PRKCEMYH911156711897493 Affinity Capture-MS; Affinity Capture-Western
PRKCEMYH911071211897493 Affinity Capture-MS; Affinity Capture-Western
MARK4MYH911071214594945 Affinity Capture-MS
MARK4MYH912176014594945 Affinity Capture-MS
MYL9MYH911567016169070 Two-hybrid
MYL9MYH911071216169070 Two-hybrid
ASCC2MYH912392116169070 Two-hybrid
ASCC2MYH911071216169070 Two-hybrid
USP1MYH911324119615732 Affinity Capture-MS
USP1MYH911071219615732 Affinity Capture-MS
USP45MYH912443019615732 Affinity Capture-MS
USP45MYH911071219615732 Affinity Capture-MS
RAC1MYH911071220936779 Two-hybrid
RAC1MYH911181720936779 Two-hybrid
YWHAZMYH911336620936779 Two-hybrid
YWHAZMYH911071220936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
MYH9D22S283, rs1005570, rs11089788, rs11703137, rs11703176, rs11704382, rs1557538, rs2239781, rs2239784, rs2239788, rs2294356, rs3830104, rs5756129, rs5756130, rs5756133, rs5756154, rs5756168, rs6000262, rs735854, rs739096, rs9306310, rs933224, rs9610489, rs9610498 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:107717
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-5870'