AutismKB 2.0

Annotation Details for MYO6


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Basic Information Top
Gene Symbol:MYO6 ( DFNA22,DFNB37,KIAA0389 )
Gene Full Name: myosin VI
Band: 6q14.1
Quick LinksEntrez ID:4646; OMIM: 600970; Uniprot ID:MYO6_HUMAN; ENSEMBL ID: ENSG00000196586; HGNC ID: 7605
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IDA-ruffle9852149
GO:0005634IDA-nucleus16507995
GO:0005654IDA-nucleoplasm16949370
GO:0005737IDA-cytoplasm9852149
GO:0005737ISS-cytoplasm-
GO:0005765TAS-lysosomal membrane-
GO:0005794IDA-Golgi apparatus16507995
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0005902IEA-microvillus-
GO:0005905IEA-clathrin-coated pit-
GO:0005938ISS-cell cortex-
GO:0016020IDA-membrane19946888
GO:0016461TAS-unconventional myosin complex9259267
GO:0016591IDA-DNA-directed RNA polymerase II, holoenzyme16949370
GO:0030139ISScolocalizes_withendocytic vesicle-
GO:0030665IEA-clathrin-coated vesicle membrane-
GO:0031410IDA-cytoplasmic vesicle16507995
GO:0031941IDA-filamentous actin9852149
GO:0031941ISScolocalizes_withfilamentous actin-
GO:0031965IDA-nuclear membrane16507995
GO:0032587IEA-ruffle membrane-
GO:0045177IEA-apical part of cell-
GO:0045334IDAcolocalizes_withclathrin-coated endocytic vesicle11447109
GO:0048471IDA-perinuclear region of cytoplasm9852149
GO:0048471ISS-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0003774ISS-motor activity-
GO:0003779TAS-actin binding10519557
GO:0005515IPI-protein binding11447109
GO:0005516ISS-calmodulin binding-
GO:0005516TAS-calmodulin binding12857860
GO:0005524IEA-ATP binding-
GO:0043531ISS-ADP binding-
GO:0045296IDA-cadherin binding25468996
GO:0051015IDA-actin filament binding9852149
GO:0051015ISS-actin filament binding-
GO:0060001NAS-minus-end directed microfilament motor activity10519557
GO ID Evidence Qualifier GO_term References
GO:0006886ISS-intracellular protein transport-
GO:0006897IMP-endocytosis15247260
GO:0006897ISS-endocytosis-
GO:0007605IEA-sensory perception of sound-
GO:0030048ISS-actin filament-based movement-
GO:0030048NAS-actin filament-based movement10519557
GO:0030330IDA-DNA damage response, signal transduction by p53 class mediator16507995
GO:0042493IEA-response to drug-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter16949370
GO:0051046IMP-regulation of secretion15837803
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MYO6APC11073020936779 Two-hybrid
MYO6APC10682120936779 Two-hybrid
MYO6CALM211073016169070 Two-hybrid
MYO6CALM210725616169070 Two-hybrid
MYO6CDC4210743320936779 Two-hybrid
MYO6CDC4211073020936779 Two-hybrid
MYO6CYLD11073019615732 Affinity Capture-MS
MYO6CYLD10792019615732 Affinity Capture-MS
MYO6DAB111073011967127 Reconstituted Complex
MYO6DAB110797011967127 Reconstituted Complex
MYO6DAB211073011906161 11967127 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
MYO6DAB210797111906161 11967127 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
GIPC1MYO611597812857860 17353931 Affinity Capture-MS; Affinity Capture-Western
GIPC1MYO611073012857860 17353931 Affinity Capture-MS; Affinity Capture-Western
USP25MYO611073019615732 Affinity Capture-MS
USP25MYO611889519615732 Affinity Capture-MS
USP11MYO611073019615732 Affinity Capture-MS
USP11MYO611386619615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104785
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030318-3'