AutismKB 2.0

Annotation Details for ATF4


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Basic Information Top
Gene Symbol:ATF4 ( CREB-2,CREB2,TAXREB67,TXREB )
Gene Full Name: activating transcription factor 4 (tax-responsive enhancer element B67)
Band: 22q13.1
Quick LinksEntrez ID:468; OMIM: 604064; Uniprot ID:ATF4_HUMAN; ENSEMBL ID: ENSG00000128272; HGNC ID: 786
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11478948
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm23392669
GO:0005737ISS-cytoplasm-
GO:0005815IEA-microtubule organizing center-
GO:0032590IEA-dendrite membrane-
GO:0034399IDA-nuclear periphery23392669
GO:0043005IDA-neuron projection23392669
GO:1990037IDA-Lewy body core23392669
GO:1990589IDA-ATF4-CREB1 transcription factor complex12871976
GO:1990590IDA-ATF1-ATF4 transcription factor complex12871976
GO:1990617IDA-CHOP-ATF4 complex11478948
GO:1990617IPI-CHOP-ATF4 complex18940792
GO:1990617NAS-CHOP-ATF4 complex15775988
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0000981IC-RNA polymerase II transcription factor activity, sequence-specific DNA binding21113145
GO:0000981IDA-RNA polymerase II transcription factor activity, sequence-specific DNA binding11478948
GO:0001046ISS-core promoter sequence-specific DNA binding-
GO:0001076IC-transcription factor activity, RNA polymerase II transcription factor binding12871976
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001085IPI-RNA polymerase II transcription factor binding11478948
GO:0003677IDA-DNA binding15788408
GO:0003677ISS-DNA binding-
GO:0003700ISS-transcription factor activity, sequence-specific DNA binding-
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding12689582
GO:0005515IPI-protein binding9488481
GO:0008022IEA-protein C-terminus binding-
GO:0043522IDA-leucine zipper domain binding11478948
GO:0043565IDA-sequence-specific DNA binding22915762
GO:0044212IDA-transcription regulatory region DNA binding21113145
GO:0044212IDAcontributes_totranscription regulatory region DNA binding12871976
GO:0044212TAS-transcription regulatory region DNA binding23392669
GO:0046982NAS-protein heterodimerization activity15775988
GO ID Evidence Qualifier GO_term References
GO:0006094ISS-gluconeogenesis-
GO:0006355ISS-regulation of transcription, DNA-templated-
GO:0006366ISS-transcription from RNA polymerase II promoter-
GO:0006520TAS-cellular amino acid metabolic process12689582
GO:0007214IEA-gamma-aminobutyric acid signaling pathway-
GO:0010575IMP-positive regulation of vascular endothelial growth factor production22915762
GO:0010628IMP-positive regulation of gene expression24136195
GO:0032057ISS-negative regulation of translational initiation in response to stress-
GO:0032922ISS-circadian regulation of gene expression-
GO:0034198ISS-cellular response to amino acid starvation-
GO:0034644ISS-cellular response to UV-
GO:0034976IDA-response to endoplasmic reticulum stress19061639
GO:0034976IMP-response to endoplasmic reticulum stress24939851
GO:0036003IC-positive regulation of transcription from RNA polymerase II promoter in response to stress25681212
GO:0036091IMP-positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress21113145
GO:0036091ISS-positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress23392669
GO:0036499TAS-PERK-mediated unfolded protein response22013210
GO:0042149IMP-cellular response to glucose starvation22915762
GO:0042789ISS-mRNA transcription from RNA polymerase II promoter-
GO:0043065TAS-positive regulation of apoptotic process23392669
GO:0043267IEA-negative regulation of potassium ion transport-
GO:0043525ISS-positive regulation of neuron apoptotic process-
GO:0045893IDA-positive regulation of transcription, DNA-templated15775988
GO:0045893IMP-positive regulation of transcription, DNA-templated11960987
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045893NAS-positive regulation of transcription, DNA-templated9190894
GO:0045943IMP-positive regulation of transcription from RNA polymerase I promoter22915762
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter11478948
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter15788408
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0061395TAS-positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance14685163
GO:0070059ISS-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-
GO:1903204IGI-negative regulation of oxidative stress-induced neuron death23392669
GO:1903351IMP-cellular response to dopamine24136195
GO:1990440IDA-positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress12871976
GO:1990440IMP-positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress21113145
GO:1990737IEA-response to manganese-induced endoplasmic reticulum stress-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ATF4ATF310695719164757 Affinity Capture-Western
ATF4ATF310695819164757 Affinity Capture-Western
JUNATF41069581827203 20936779 Reconstituted Complex; Two-hybrid
JUNATF41099281827203 20936779 Reconstituted Complex; Two-hybrid
CREBBPATF41069589295363 Reconstituted Complex
CREBBPATF41077779295363 Reconstituted Complex
GTF2BATF41069589295363 Reconstituted Complex
GTF2BATF41092149295363 Reconstituted Complex
GTF2F2ATF41069589295363 Reconstituted Complex
GTF2F2ATF41092189295363 Reconstituted Complex
TBPATF41069589295363 Reconstituted Complex
TBPATF41127719295363 Reconstituted Complex
GABBR2ATF410695811087824 Affinity Capture-Western
GABBR2ATF411493811087824 Affinity Capture-Western
GABBR1ATF410695811087824 Affinity Capture-Western; Two-hybrid
GABBR1ATF410882511087824 Affinity Capture-Western; Two-hybrid
TRIB3ATF410695812743605 18276110 Affinity Capture-Western; Two-hybrid
TRIB3ATF412175612743605 18276110 Affinity Capture-Western; Two-hybrid
DISC1ATF410695812812986 Two-hybrid
DISC1ATF411806112812986 Two-hybrid
POLR2CATF410695812860379 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
POLR2CATF411142812860379 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EIF2AATF410695815475356 Affinity Capture-Western
EIF2AATF412382215475356 Affinity Capture-Western
CCDC106ATF410695816169070 Two-hybrid
CCDC106ATF411895216169070 Two-hybrid
TREX2ATF411638816189514 Two-hybrid
TREX2ATF410695816189514 Two-hybrid
LDOC1ATF410695816189514 Two-hybrid
LDOC1ATF411716916189514 Two-hybrid
GPS2ATF410695816189514 Two-hybrid
GPS2ATF410913216189514 Two-hybrid
PTCD3ATF410695816189514 Two-hybrid
PTCD3ATF412036616189514 Two-hybrid
TTRATF410695816189514 Two-hybrid
TTRATF411312716189514 Two-hybrid
UBCATF410695816219772 Affinity Capture-Western
UBCATF411316416219772 Affinity Capture-Western
BTRCATF410695816219772 Affinity Capture-Western
BTRCATF411445716219772 Affinity Capture-Western
EP300ATF410695816219772 Affinity Capture-Western; Reconstituted Complex
EP300ATF410834716219772 Affinity Capture-Western; Reconstituted Complex
KAT2BATF411437517726049 Reconstituted Complex
KAT2BATF410695817726049 Reconstituted Complex
GTF2A1LATF410695820211142 Two-hybrid
GTF2A1LATF411622520211142 Two-hybrid
ZNF226ATF411355220211142 Two-hybrid
ZNF226ATF410695820211142 Two-hybrid
TRIM24ATF410695820211142 Two-hybrid
TRIM24ATF411433320211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
ATF4rs17001266, rs4894 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88096
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2340'