AutismKB 2.0

Annotation Details for NCF2


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Basic Information Top
Gene Symbol:NCF2 ( FLJ93058,NCF-2,NOXA2,P67-PHOX,P67PHOX )
Gene Full Name: neutrophil cytosolic factor 2
Band: 1q25.3
Quick LinksEntrez ID:4688; OMIM: 608515; Uniprot ID:NCF2_HUMAN; ENSEMBL ID: ENSG00000116701; HGNC ID: 7661
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001669IEA-acrosomal vesicle-
GO:0005730IDA-nucleolus-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0032010TAS-phagolysosome-
GO:0043020TAS-NADPH oxidase complex7938008
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding7938008
GO:0008022IPI-protein C-terminus binding9365277
GO:0009055TAS-electron carrier activity1692159
GO:0016175IEA-superoxide-generating NADPH oxidase activity-
GO:0016176IEA-superoxide-generating NADPH oxidase activator activity-
GO:0048365IEA-Rac GTPase binding-
GO ID Evidence Qualifier GO_term References
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0006801TAS-superoxide metabolic process7938008
GO:0006909IEA-phagocytosis-
GO:0006968TAS-cellular defense response1692159
GO:0034599TAS-cellular response to oxidative stress-
GO:0042554TAS-superoxide anion generation7938008
GO:0043085IEA-positive regulation of catalytic activity-
GO:0045087TAS-innate immune response7938008
GO:0045454TAS-cell redox homeostasis-
GO:0045730TAS-respiratory burst7938008
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0055114IEA-oxidation-reduction process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NCF2ACTB11076811027608 Far Western
NCF2ACTB10657511027608 Far Western
NCF2CDC421107689642115 Reconstituted Complex
NCF2CDC421074339642115 Reconstituted Complex
NCF2CYBA11076811733522 11917128 Protein-peptide; Reconstituted Complex
NCF2CYBA10791511733522 11917128 Protein-peptide; Reconstituted Complex
NCF1NCF21107687938008 10486263 11733522 11796733 12169629 Co-crystal Structure; Far Western; Protein-peptide; Reconstituted Complex
NCF1NCF25757247938008 10486263 11733522 11796733 12169629 Co-crystal Structure; Far Western; Protein-peptide; Reconstituted Complex
NCF4NCF21107689083043 11483497 11796733 11893732 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
NCF4NCF21107699083043 11483497 11796733 11893732 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
RAC1NCF21107689624165 9642115 11090627 Co-crystal Structure; Reconstituted Complex
RAC1NCF21118179624165 9642115 11090627 Co-crystal Structure; Reconstituted Complex
RAC2NCF21107689624165 9642115 Reconstituted Complex; Two-hybrid
RAC2NCF21118189624165 9642115 Reconstituted Complex; Two-hybrid
PRKDCNCF21115779914162 Biochemical Activity
PRKDCNCF21107689914162 Biochemical Activity
SYTL1NCF211076811278853 Reconstituted Complex
SYTL1NCF212438911278853 Reconstituted Complex
PRDX6NCF211495612121978 Affinity Capture-MS; Two-hybrid
PRDX6NCF211076812121978 Affinity Capture-MS; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97284
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070209-29'