AutismKB 2.0

Annotation Details for NEDD4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NEDD4 ( KIAA0093,MGC176705,NEDD4-1,RPF1 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 4
Band: 15q21.3
Quick LinksEntrez ID:4734; OMIM: 602278; Uniprot ID:NEDD4_HUMAN; ENSEMBL ID: ENSG00000069869; HGNC ID: 7727
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151ISS-ubiquitin ligase complex-
GO:0000785IDA-chromatin17996703
GO:0005737IDA-cytoplasm12796489
GO:0005794IDA-Golgi apparatus16118794
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol9405440
GO:0005886IDA-plasma membrane16118794
GO:0005886IMP-plasma membrane15126635
GO:0005938IDA-cell cortex9990509
GO:0016327TAS-apicolateral plasma membrane9405440
GO:0043197IEA-dendritic spine-
GO:0048471IDA-perinuclear region of cytoplasm9990509
GO:0070062IDA-extracellular exosome23533145
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding9305852
GO:0019871IDA-sodium channel inhibitor activity10642508
GO:0019904IPI-protein domain specific binding12907594
GO:0031698IDA-beta-2 adrenergic receptor binding18544533
GO:0035255IEA-ionotropic glutamate receptor binding-
GO:0043130IDA-ubiquitin binding9990509
GO:0050815ISS-phosphoserine residue binding-
GO:0050816ISS-phosphothreonine residue binding-
GO:0061630IDA-ubiquitin protein ligase activity17996703
GO:0070063IPI-RNA polymerase binding17996703
GO:0070064IMP-proline-rich region binding15126635
GO:0070064IPI-proline-rich region binding11342538
GO ID Evidence Qualifier GO_term References
GO:0002250IEA-adaptive immune response-
GO:0003151IEA-outflow tract morphogenesis-
GO:0003197IEA-endocardial cushion development-
GO:0006513IEA-protein monoubiquitination-
GO:0006622IDA-protein targeting to lysosome17116753
GO:0007041IDA-lysosomal transport18544533
GO:0007528IEA-neuromuscular junction development-
GO:0010766IDA-negative regulation of sodium ion transport10642508
GO:0010768IMP-negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage17996703
GO:0014068IMP-positive regulation of phosphatidylinositol 3-kinase signaling17218260
GO:0016241TAS-regulation of macroautophagy25809873
GO:0016567IDA-protein ubiquitination17996703
GO:0019089IMP-transmission of virus15126635
GO:0030948ISS-negative regulation of vascular endothelial growth factor receptor signaling pathway-
GO:0031175IEP-neuron projection development9990509
GO:0031623IDA-receptor internalization18544533
GO:0032801IDA-receptor catabolic process18544533
GO:0034644IMP-cellular response to UV17996703
GO:0034765IDA-regulation of ion transmembrane transport17289006
GO:0042110IEA-T cell activation-
GO:0042391IDA-regulation of membrane potential17289006
GO:0042787IDA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process20086093
GO:0042787IMP-protein ubiquitination involved in ubiquitin-dependent protein catabolic process17218260
GO:0042921IDA-glucocorticoid receptor signaling pathway8649367
GO:0043162IMP-ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway20086093
GO:0044111IMP-development involved in symbiotic interaction15126635
GO:0045732IDA-positive regulation of protein catabolic process14973438
GO:0046824IDA-positive regulation of nucleocytoplasmic transport17218261
GO:0048514IEA-blood vessel morphogenesis-
GO:0048814ISS-regulation of dendrite morphogenesis-
GO:0050807IEA-regulation of synapse organization-
GO:0050847IDA-progesterone receptor signaling pathway8649367
GO:0051592TAS-response to calcium ion9405440
GO:0070534ISS-protein K63-linked ubiquitination-
GO:1901016IDA-regulation of potassium ion transmembrane transporter activity17289006
GO:2000650IDA-negative regulation of sodium ion transmembrane transporter activity10642508
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NEDD4ARRB110690118544533 Affinity Capture-Western
NEDD4ARRB111081118544533 Affinity Capture-Western
NEDD4ARRB210690218544533 Affinity Capture-Western
NEDD4ARRB211081118544533 Affinity Capture-Western
NEDD4CAD10724316055720 Affinity Capture-MS
NEDD4CAD11081116055720 Affinity Capture-MS
NEDD4CBLB11081112907674 Affinity Capture-Western; Reconstituted Complex
NEDD4CBLB10731612907674 Affinity Capture-Western; Reconstituted Complex
NEDD4CDC25C11081110037602 Affinity Capture-Western; Protein-peptide
NEDD4CDC25C10743010037602 Affinity Capture-Western; Protein-peptide
NEDD4DDX3X10802016055720 Affinity Capture-MS
NEDD4DDX3X11081116055720 Affinity Capture-MS
NEDD4DIAPH110807316055720 Affinity Capture-MS
NEDD4DIAPH111081116055720 Affinity Capture-MS
NEDD4EPRS10837216055720 Affinity Capture-MS
NEDD4EPRS11081116055720 Affinity Capture-MS
NEDD4MLANA10860415703212 Affinity Capture-Western; Reconstituted Complex
NEDD4MLANA11081115703212 Affinity Capture-Western; Reconstituted Complex
NEDD4HNRNPK10943116055720 Affinity Capture-MS
NEDD4HNRNPK11081116055720 Affinity Capture-MS
NEDD4HNRNPL11081116055720 Affinity Capture-MS
NEDD4HNRNPL10943216055720 Affinity Capture-MS
NEDD4HNRNPU10943316055720 Affinity Capture-MS
NEDD4HNRNPU11081116055720 Affinity Capture-MS
NEDD4IGF1R10970112697834 18632619 Affinity Capture-Western; Biochemical Activity
NEDD4IGF1R11081112697834 18632619 Affinity Capture-Western; Biochemical Activity
NEDD4SMAD211026215496141 Affinity Capture-Western
NEDD4SMAD211081115496141 Affinity Capture-Western
NEDD4SMAD311026315496141 Affinity Capture-Western
NEDD4SMAD311081115496141 Affinity Capture-Western
NEDD4SMAD611026615496141 Affinity Capture-Western
NEDD4SMAD611081115496141 Affinity Capture-Western
NEDD4SMAD711026715496141 Affinity Capture-Western
NEDD4SMAD711081115496141 Affinity Capture-Western
UBE2D2NEDD41108119182527 9990509 Biochemical Activity; Two-hybrid
UBE2D2NEDD41131709182527 9990509 Biochemical Activity; Two-hybrid
UBE2E1NEDD41131729990509 18287095 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
UBE2E1NEDD41108119990509 18287095 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
UBE2D3NEDD41131719990509 18498243 Biochemical Activity; Reconstituted Complex
UBE2D3NEDD41108119990509 18498243 Biochemical Activity; Reconstituted Complex
UBE2L3NEDD41131809990509 17719543 18498246 Biochemical Activity; Reconstituted Complex
UBE2L3NEDD41108119990509 17719543 18498246 Biochemical Activity; Reconstituted Complex
SCNN1ANEDD411081110642508 11244092 12167593 Far Western; Reconstituted Complex
SCNN1ANEDD411224110642508 11244092 12167593 Far Western; Reconstituted Complex
SCNN1BNEDD411224210642508 11244092 12167593 Far Western; Reconstituted Complex
SCNN1BNEDD411081110642508 11244092 12167593 Far Western; Reconstituted Complex
SCNN1GNEDD411224410642508 11244092 12167593 Far Western; Reconstituted Complex
SCNN1GNEDD411081110642508 11244092 12167593 Far Western; Reconstituted Complex
SGK1NEDD411234411696533 12729930 Reconstituted Complex
SGK1NEDD411081111696533 12729930 Reconstituted Complex
N4BP3NEDD411081111717310 Affinity Capture-Western
N4BP3NEDD411675511717310 Affinity Capture-Western
HGSNEDD411081112230472 Biochemical Activity
HGSNEDD411459312230472 Biochemical Activity
NDFIP2NEDD412007412796489 15252135 Affinity Capture-Western; Reconstituted Complex
NDFIP2NEDD411081112796489 15252135 Affinity Capture-Western; Reconstituted Complex
PMEPA1NEDD411081112907594 Affinity Capture-Western; Reconstituted Complex
PMEPA1NEDD412126212907594 Affinity Capture-Western; Reconstituted Complex
SCN5ANEDD411223615217910 Biochemical Activity; Reconstituted Complex
SCN5ANEDD411081115217910 Biochemical Activity; Reconstituted Complex
SMURF2NEDD412226515496141 Affinity Capture-Western
SMURF2NEDD411081115496141 Affinity Capture-Western
SKILNEDD411238915496141 Affinity Capture-Western
SKILNEDD411081115496141 Affinity Capture-Western
TP73NEDD411301415678106 Affinity Capture-Western
TP73NEDD411081115678106 Affinity Capture-Western
PRPF8NEDD411584216055720 Affinity Capture-MS
PRPF8NEDD411081116055720 Affinity Capture-MS
NUDT21NEDD411623716055720 Affinity Capture-MS
NUDT21NEDD411081116055720 Affinity Capture-MS
HNRNPUL1NEDD411628116055720 Affinity Capture-MS
HNRNPUL1NEDD411081116055720 Affinity Capture-MS
POLR3ANEDD411081116055720 Affinity Capture-MS
POLR3ANEDD411630116055720 Affinity Capture-MS
AMOTL1NEDD412755916055720 Affinity Capture-MS
AMOTL1NEDD411081116055720 Affinity Capture-MS
DHX30NEDD411657116055720 Affinity Capture-MS
DHX30NEDD411081116055720 Affinity Capture-MS
WBP2NEDD411081116055720 Affinity Capture-MS
WBP2NEDD411710216055720 Affinity Capture-MS
CPSF1NEDD411081116055720 Affinity Capture-MS
CPSF1NEDD411894616055720 Affinity Capture-MS
RAPGEF6NEDD411081116055720 Affinity Capture-MS
RAPGEF6NEDD411970516055720 Affinity Capture-MS
POLR2BNEDD411142716055720 Affinity Capture-MS
POLR2BNEDD411081116055720 Affinity Capture-MS
POLR2CNEDD411142816055720 Affinity Capture-MS
POLR2CNEDD411081116055720 Affinity Capture-MS
POLR2ENEDD411143016055720 Affinity Capture-MS
POLR2ENEDD411081116055720 Affinity Capture-MS
RPS3ANEDD411081116055720 Affinity Capture-MS
RPS3ANEDD411210316055720 Affinity Capture-MS
SRSF7NEDD411233016055720 Affinity Capture-MS
SRSF7NEDD411081116055720 Affinity Capture-MS
SMARCC1NEDD411081116055720 Affinity Capture-MS
SMARCC1NEDD411248316055720 Affinity Capture-MS
RPAP3NEDD412278316055720 Affinity Capture-MS
RPAP3NEDD411081116055720 Affinity Capture-MS
RPAP2NEDD412295916055720 Affinity Capture-MS
RPAP2NEDD411081116055720 Affinity Capture-MS
GRINL1ANEDD412349816055720 Affinity Capture-MS
GRINL1ANEDD411081116055720 Affinity Capture-MS
ARID1ANEDD411081116055720 Affinity Capture-MS
ARID1ANEDD411389416055720 Affinity Capture-MS
RUVBL1NEDD411416616055720 Affinity Capture-MS
RUVBL1NEDD411081116055720 Affinity Capture-MS
C19orf2NEDD411426416055720 Affinity Capture-MS
C19orf2NEDD411081116055720 Affinity Capture-MS
THRAP3NEDD411529216055720 Affinity Capture-MS
THRAP3NEDD411081116055720 Affinity Capture-MS
POLR2ANEDD411081116055720 17996703 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
POLR2ANEDD411142616055720 17996703 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
NEDD4NEDD411081116055720 18287095 Affinity Capture-MS; Biochemical Activity
CPSF6NEDD411623816055720 Affinity Capture-MS; Reconstituted Complex
CPSF6NEDD411081116055720 Affinity Capture-MS; Reconstituted Complex
UBAP2LNEDD411081116055720 Reconstituted Complex
UBAP2LNEDD411522716055720 Reconstituted Complex
NTRK1NEDD411096916701206 Affinity Capture-Western; Biochemical Activity
NTRK1NEDD411081116701206 Affinity Capture-Western; Biochemical Activity
SLC6A3NEDD411242216885233 Affinity Capture-Western
SLC6A3NEDD411081116885233 Affinity Capture-Western
GGA3NEDD411081117116753 Affinity Capture-Western
GGA3NEDD411677517116753 Affinity Capture-Western
LAPTM5NEDD411358017116753 Affinity Capture-Western
LAPTM5NEDD411081117116753 Affinity Capture-Western
UBCNEDD411316417719543 18287095 Affinity Capture-Western; Reconstituted Complex
UBCNEDD411081117719543 18287095 Affinity Capture-Western; Reconstituted Complex
ISG15NEDD411499518287095 Affinity Capture-Western
ISG15NEDD411081118287095 Affinity Capture-Western
UBA1NEDD411316518287095 18498243 Reconstituted Complex
UBA1NEDD411081118287095 18498243 Reconstituted Complex
PTENNEDD411170018498243 Biochemical Activity; Reconstituted Complex
PTENNEDD411081118498243 Biochemical Activity; Reconstituted Complex
TTYH3NEDD412327718577513 Affinity Capture-Western
TTYH3NEDD411081118577513 Affinity Capture-Western
TTYH2NEDD412508718577513 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TTYH2NEDD411081118577513 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
AP1G2NEDD411442018772139 Affinity Capture-Western; Biochemical Activity
AP1G2NEDD411081118772139 Affinity Capture-Western; Biochemical Activity
SCAMP3NEDD411537819158374 Affinity Capture-Western; Two-hybrid
SCAMP3NEDD411081119158374 Affinity Capture-Western; Two-hybrid
PDCD6IPNEDD411533220519395 Affinity Capture-Western
PDCD6IPNEDD411081120519395 Affinity Capture-Western
GABARAPNEDD411646520562859 Affinity Capture-MS
GABARAPNEDD411081120562859 Affinity Capture-MS
GABARAPL2NEDD411647320562859 Affinity Capture-MS
GABARAPL2NEDD411081120562859 Affinity Capture-MS
GABARAPL1NEDD411722320562859 Affinity Capture-MS
GABARAPL1NEDD411081120562859 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
TP73NEDD421606615678106 p73-alpha interacts with an unspecified isoform of Nedd4.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97297
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved