AutismKB 2.0

Annotation Details for NEDD8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NEDD8 ( FLJ43224,MGC104393,MGC125896,MGC125897,Nedd-8 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 8
Band: 14q12
Quick LinksEntrez ID:4738; OMIM: 603171; Uniprot ID:NEDD8_HUMAN; ENSEMBL ID: ENSG00000129559; HGNC ID: 7732
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus9353319
GO:0005654TAS-nucleoplasm-
GO:0005829TAS-cytosol-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding15988528
GO:0031625IPI-ubiquitin protein ligase binding15694336
GO ID Evidence Qualifier GO_term References
GO:0006357IEA-regulation of transcription from RNA polymerase II promoter-
GO:0006464TAS-cellular protein modification process9694792
GO:0006508TAS-proteolysis9694792
GO:0006511TAS-ubiquitin-dependent protein catabolic process9353319
GO:0006879TAS-cellular iron ion homeostasis-
GO:0007179TAS-transforming growth factor beta receptor signaling pathway-
GO:0008104IEA-protein localization-
GO:0009653TAS-anatomical structure morphogenesis9694792
GO:0014070IEA-response to organic cyclic compound-
GO:0016567TAS-protein ubiquitination-
GO:0016579TAS-protein deubiquitination-
GO:0043687TAS-post-translational protein modification-
GO:0045116IDA-protein neddylation10500095
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NEDD8PARP110665216620772 Affinity Capture-MS
NEDD8PARP111081516620772 Affinity Capture-MS
NEDD8AHR10669912215427 Affinity Capture-Western; Reconstituted Complex
NEDD8AHR11081512215427 Affinity Capture-Western; Reconstituted Complex
NEDD8CDK211081517353931 Affinity Capture-MS
NEDD8CDK210745217353931 Affinity Capture-MS
NEDD8DDB111081516964240 Affinity Capture-MS
NEDD8DDB110800916964240 Affinity Capture-MS
NEDD8EGFR11081516735510 Affinity Capture-Western
NEDD8EGFR10827616735510 Affinity Capture-Western
UCHL3NEDD81131949790970 Reconstituted Complex; Two-hybrid
UCHL3NEDD81108159790970 Reconstituted Complex; Two-hybrid
UBE2MNEDD811081510207026 16620772 16735510 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
UBE2MNEDD811450410207026 16620772 16735510 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
UBA3NEDD811081510207026 16620772 Affinity Capture-MS; Biochemical Activity; Reconstituted Complex
UBA3NEDD811450310207026 16620772 Affinity Capture-MS; Biochemical Activity; Reconstituted Complex
UBA2NEDD811536510217437 Reconstituted Complex
UBA2NEDD811081510217437 Reconstituted Complex
NUB1NEDD811081511585840 14757770 Affinity Capture-Western; Reconstituted Complex
NUB1NEDD811967011585840 14757770 Affinity Capture-Western; Reconstituted Complex
PSMD4NEDD811081511585840 Reconstituted Complex
PSMD4NEDD811168311585840 Reconstituted Complex
CUL4ANEDD811402912481031 16620772 16964240 Affinity Capture-MS
CUL4ANEDD811081512481031 16620772 16964240 Affinity Capture-MS
RBX1NEDD811530112481031 Affinity Capture-MS
RBX1NEDD811081512481031 Affinity Capture-MS
SENP8NEDD812581912759363 Reconstituted Complex
SENP8NEDD811081512759363 Reconstituted Complex
UCHL1NEDD811319216169070 Two-hybrid
UCHL1NEDD811081516169070 Two-hybrid
CUL1NEDD811403216177058 16620772 18627766 Affinity Capture-MS; Affinity Capture-Western
CUL1NEDD811081516177058 16620772 18627766 Affinity Capture-MS; Affinity Capture-Western
PTK2NEDD811171916620772 Affinity Capture-MS
PTK2NEDD811081516620772 Affinity Capture-MS
CUL4BNEDD811402816620772 Affinity Capture-MS
CUL4BNEDD811081516620772 Affinity Capture-MS
NAE1NEDD811440216620772 Affinity Capture-MS
NAE1NEDD811081516620772 Affinity Capture-MS
CUL3NEDD811081516620772 17192413 Affinity Capture-MS; Affinity Capture-Western
CUL3NEDD811403016620772 17192413 Affinity Capture-MS; Affinity Capture-Western
TP53NEDD811081516620772 17098746 17369817 17546054 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TP53NEDD811301016620772 17098746 17369817 17546054 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CUL2NEDD811081516620772 18173839 Affinity Capture-MS; Reconstituted Complex
CUL2NEDD811403116620772 18173839 Affinity Capture-MS; Reconstituted Complex
UBCNEDD811316416735510 Affinity Capture-Western
UBCNEDD811081516735510 Affinity Capture-Western
HGSNEDD811081516735510 Affinity Capture-Western
HGSNEDD811459316735510 Affinity Capture-Western
SIRT1NEDD811698316998474 Affinity Capture-Western
SIRT1NEDD811081516998474 Affinity Capture-Western
C11orf17NEDD811081516998474 Affinity Capture-Western
C11orf17NEDD812118016998474 Affinity Capture-Western
FBXO4NEDD811765617353931 Affinity Capture-MS
FBXO4NEDD811081517353931 Affinity Capture-MS
TFE3NEDD811288817353931 Affinity Capture-MS
TFE3NEDD811081517353931 Affinity Capture-MS
VHLNEDD811326917353931 Affinity Capture-MS
VHLNEDD811081517353931 Affinity Capture-MS
MAGED1NEDD811487917353931 Affinity Capture-MS
MAGED1NEDD811081517353931 Affinity Capture-MS
CUL5NEDD811374318805092 Co-crystal Structure
CUL5NEDD811081518805092 Co-crystal Structure
COPS6NEDD811617619615732 Affinity Capture-MS
COPS6NEDD811081519615732 Affinity Capture-MS
COPS5NEDD811618319615732 Affinity Capture-MS
COPS5NEDD811081519615732 Affinity Capture-MS
USP25NEDD811081519615732 Affinity Capture-MS
USP25NEDD811889519615732 Affinity Capture-MS
USP13NEDD811446519615732 Affinity Capture-MS
USP13NEDD811081519615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97301
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030616-588'