AutismKB 2.0

Annotation Details for NEK2


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Basic Information Top
Gene Symbol:NEK2 ( HsPK21,NEK2A,NLK1 )
Gene Full Name: NIMA (never in mitosis gene a)-related kinase 2
Band: 1q32.3
Quick LinksEntrez ID:4751; OMIM: 604043; Uniprot ID:NEK2_HUMAN; ENSEMBL ID: ENSG00000117650; HGNC ID: 7745
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000776IDA-kinetochore14978040
GO:0000776IDAcolocalizes_withkinetochore17621308
GO:0000777IEA-condensed chromosome kinetochore-
GO:0000794IEA-condensed nuclear chromosome-
GO:0000922IEA-spindle pole-
GO:0005654IDA-nucleoplasm-
GO:0005730IEA-nucleolus-
GO:0005813IDA-centrosome21399614
GO:0005829TAS-cytosol-
GO:0005874IEA-microtubule-
GO:0030496IEA-midbody-
GO:0043234IMP-protein complex10880350
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity10880350
GO:0004672IMP-protein kinase activity24554434
GO:0004674TAS-protein serine/threonine kinase activity16280549
GO:0005515IPI-protein binding9647649
GO:0005524IEA-ATP binding-
GO:0019903IPI-protein phosphatase binding10880350
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000070IEA-mitotic sister chromatid segregation-
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0000278TAS-mitotic cell cycle9430639
GO:0001824IEA-blastocyst development-
GO:0006468IDA-protein phosphorylation21076410
GO:0006468IMP-protein phosphorylation24554434
GO:0007059IDA-chromosome segregation14978040
GO:0007088TAS-regulation of mitotic nuclear division9430639
GO:0032212IMP-positive regulation of telomere maintenance via telomerase21531765
GO:0043392IEA-negative regulation of DNA binding-
GO:0046602IMP-regulation of mitotic centrosome separation26220856
GO:0046602TAS-regulation of mitotic centrosome separation16280549
GO:0046777IDA-protein autophosphorylation17626005
GO:0046777IMP-protein autophosphorylation10880350
GO:0051225TAS-spindle assembly16280549
GO:0051299IDA-centrosome separation18086858
GO:0051301IEA-cell division-
GO:0051321IEA-meiotic cell cycle-
GO:0051973IMP-positive regulation of telomerase activity21531765
GO:0051988IMP-regulation of attachment of spindle microtubules to kinetochore18297113
GO:0090307IEA-mitotic spindle assembly-
GO:0097711TAS-ciliary basal body docking-
GO:1903126IMP-negative regulation of centriole-centriole cohesion24554434
GO:1904355IMP-positive regulation of telomere capping21531765
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NDC80NEK21108269295362 12386167 Biochemical Activity; Reconstituted Complex; Two-hybrid
NDC80NEK21156759295362 12386167 Biochemical Activity; Reconstituted Complex; Two-hybrid
CEP250NEK21163609647649 Biochemical Activity; Two-hybrid
CEP250NEK21108269647649 Biochemical Activity; Two-hybrid
NEK2NEK211082610347187 Co-fractionation; Reconstituted Complex; Two-hybrid
PPP1R2NEK211149712221103 Reconstituted Complex
PPP1R2NEK211082612221103 Reconstituted Complex
CLEC4CNEK212801212386167 Affinity Capture-Western; Two-hybrid
CLEC4CNEK211082612386167 Affinity Capture-Western; Two-hybrid
MAPK1NEK211082615358203 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1NEK211158015358203 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109359
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-752'