AutismKB 2.0

Annotation Details for ATP1A1


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Basic Information Top
Gene Symbol:ATP1A1 ( MGC3285,MGC51750 )
Gene Full Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Band: 1p13.1
Quick LinksEntrez ID:476; OMIM: 182310; Uniprot ID:AT1A1_HUMAN; ENSEMBL ID: ENSG00000163399; HGNC ID: 799
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005768IEA-endosome-
GO:0005783ISS-endoplasmic reticulum-
GO:0005794ISS-Golgi apparatus-
GO:0005886IDA-plasma membrane7711835
GO:0005886TAS-plasma membrane-
GO:0005890IDA-sodium:potassium-exchanging ATPase complex10636900
GO:0005890ISS-sodium:potassium-exchanging ATPase complex-
GO:0005901IEA-caveola-
GO:0014069IEA-postsynaptic density-
GO:0014704IEA-intercalated disc-
GO:0016020TAS-membrane1975705
GO:0016021ISS-integral component of membrane-
GO:0016323IEA-basolateral plasma membrane-
GO:0016324IEA-apical plasma membrane-
GO:0030315IEA-T-tubule-
GO:0042383ISS-sarcolemma-
GO:0042470IEA-melanosome-
GO:0043209IEA-myelin sheath-
GO:0043234IDA-protein complex22797923
GO:0070062IDA-extracellular exosome12519789
GO:1903561IDA-extracellular vesicle24769233
GO ID Evidence Qualifier GO_term References
GO:0005391IDA-sodium:potassium-exchanging ATPase activity10636900
GO:0005391ISS-sodium:potassium-exchanging ATPase activity-
GO:0005391ISScontributes_tosodium:potassium-exchanging ATPase activity-
GO:0005515IPI-protein binding11027149
GO:0005524ISS-ATP binding-
GO:0016791IEA-phosphatase activity-
GO:0019901IEA-protein kinase binding-
GO:0019904IEA-protein domain specific binding-
GO:0030506IEA-ankyrin binding-
GO:0030955ISS-potassium ion binding-
GO:0031402ISS-sodium ion binding-
GO:0043531IEA-ADP binding-
GO:0043548IEA-phosphatidylinositol 3-kinase binding-
GO:0051087IPI-chaperone binding10636900
GO:1990239IDA-steroid hormone binding14742675
GO ID Evidence Qualifier GO_term References
GO:0002026IEA-regulation of the force of heart contraction-
GO:0002028ISS-regulation of sodium ion transport-
GO:0006883IDA-cellular sodium ion homeostasis10636900
GO:0008217IEA-regulation of blood pressure-
GO:0010107IDA-potassium ion import10636900
GO:0010248IEA-establishment or maintenance of transmembrane electrochemical gradient-
GO:0016311IEA-dephosphorylation-
GO:0030007IDA-cellular potassium ion homeostasis10636900
GO:0031947IEA-negative regulation of glucocorticoid biosynthetic process-
GO:0034220TAS-ion transmembrane transport-
GO:0036376IDA-sodium ion export from cell10636900
GO:0036376ISS-sodium ion export from cell-
GO:0042493IEA-response to drug-
GO:0045822IEA-negative regulation of heart contraction-
GO:0045823IEA-positive regulation of heart contraction-
GO:0045989IEA-positive regulation of striated muscle contraction-
GO:0055119TAS-relaxation of cardiac muscle23224879
GO:0060081IEA-membrane hyperpolarization-
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071383IDA-cellular response to steroid hormone stimulus11546672
GO:0086002TAS-cardiac muscle cell action potential involved in contraction23224879
GO:0086004IEA-regulation of cardiac muscle cell contraction-
GO:0086009IDA-membrane repolarization19542013
GO:0086013IC-membrane repolarization during cardiac muscle cell action potential19542013
GO:0086064TAS-cell communication by electrical coupling involved in cardiac conduction19683723
GO:0090662IEA-ATP hydrolysis coupled transmembrane transport-
GO:1903416IDA-response to glycoside11546672
GO:1903779TAS-regulation of cardiac conduction-
GO:1990573ISS-potassium ion import across plasma membrane-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FXYD1ATP1A111136314597563 Affinity Capture-Western
FXYD1ATP1A110696614597563 Affinity Capture-Western
PRKCAATP1A111156415069082 Biochemical Activity
PRKCAATP1A110696615069082 Biochemical Activity
MAPK1ATP1A111158015069082 Biochemical Activity
MAPK1ATP1A110696615069082 Biochemical Activity
MAPK3ATP1A111158115069082 Biochemical Activity
MAPK3ATP1A110696615069082 Biochemical Activity
EZH2ATP1A110844616169070 Two-hybrid
EZH2ATP1A110696616169070 Two-hybrid
HGSATP1A111459319019082 Reconstituted Complex
HGSATP1A110696619019082 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88105
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-001212-1'