AutismKB 2.0

Annotation Details for NEUROD1


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Basic Information Top
Gene Symbol:NEUROD1 ( BETA2,BHF-1,MODY6,NEUROD,bHLHa3 )
Gene Full Name: neurogenic differentiation 1
Band: 2q31.3
Quick LinksEntrez ID:4760; OMIM: 601724; Uniprot ID:NDF1_HUMAN; ENSEMBL ID: ENSG00000162992; HGNC ID: 7762
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IC-nucleus10545951
GO:0005634IDA-nucleus14752053
GO:0005654TAS-nucleoplasm-
GO:0005737IEA-cytoplasm-
GO:0090575IDA-RNA polymerase II transcription factor complex10545951
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001102IPI-RNA polymerase II activating transcription factor binding19619559
GO:0001105IDA-RNA polymerase II transcription coactivator activity19619559
GO:0003682ISS-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding10545951
GO:0003713IDA-transcription coactivator activity14752053
GO:0005515IPI-protein binding14752053
GO:0008134IPI-transcription factor binding10545951
GO:0043565IDAcontributes_tosequence-specific DNA binding10545951
GO:0046982IDA-protein heterodimerization activity14752053
GO:0046982IPI-protein heterodimerization activity10545951
GO:0070888IDA-E-box binding14752053
GO ID Evidence Qualifier GO_term References
GO:0003326IEA-pancreatic A cell fate commitment-
GO:0003329IEA-pancreatic PP cell fate commitment-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006913IEA-nucleocytoplasmic transport-
GO:0007263IDA-nitric oxide mediated signal transduction17941991
GO:0009749IMP-response to glucose10545951
GO:0009952IEA-anterior/posterior pattern specification-
GO:0021542ISS-dentate gyrus development-
GO:0021549ISS-cerebellum development-
GO:0022008TAS-neurogenesis8786144
GO:0023019IEA-signal transduction involved in regulation of gene expression-
GO:0030073IDA-insulin secretion17941991
GO:0031018ISS-endocrine pancreas development9308961
GO:0031018TAS-endocrine pancreas development-
GO:0035881ISS-amacrine cell differentiation-
GO:0035883ISS-enteroendocrine cell differentiation-
GO:0042493IEA-response to drug-
GO:0042593ISS-glucose homeostasis9308961
GO:0043065ISS-positive regulation of apoptotic process-
GO:0045597ISS-positive regulation of cell differentiation-
GO:0045666ISS-positive regulation of neuron differentiation-
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter10545951
GO:0046426IEA-negative regulation of JAK-STAT cascade-
GO:0048562ISS-embryonic organ morphogenesis9308961
GO:0048666IEA-neuron development-
GO:0048839ISS-inner ear development-
GO:0050796IC-regulation of insulin secretion10545951
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity14752053
GO:0060730ISS-regulation of intestinal epithelial structure maintenance-
GO:0071156ISS-regulation of cell cycle arrest-
GO:0071333IEA-cellular response to glucose stimulus-
GO:2000675ISS-negative regulation of type B pancreatic cell apoptotic process9308961
GO:2000679IDA-positive regulation of transcription regulatory region DNA binding19619559
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NEUROD1CCND110706711788592 Affinity Capture-Western; Phenotypic Suppression
NEUROD1CCND111083311788592 Affinity Capture-Western; Phenotypic Suppression
NEUROD1EP30010834710545951 Reconstituted Complex
NEUROD1EP30011083310545951 Reconstituted Complex
NEUROD1HTT11083312881483 Affinity Capture-Western
NEUROD1HTT10931412881483 Affinity Capture-Western
NEUROD1MAP3K1011044012881483 Affinity Capture-Western; Biochemical Activity; Two-hybrid
NEUROD1MAP3K1011083312881483 Affinity Capture-Western; Biochemical Activity; Two-hybrid
HAP1NEUROD111448012881483 Affinity Capture-Western; Two-hybrid
HAP1NEUROD111083312881483 Affinity Capture-Western; Two-hybrid
MAFANEUROD111083315665000 Affinity Capture-Western; Reconstituted Complex
MAFANEUROD113323315665000 Affinity Capture-Western; Reconstituted Complex
SMARCA4NEUROD111248116024661 Affinity Capture-Western
SMARCA4NEUROD111083316024661 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
NEUROD1rs1801262 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1339708
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-172'