AutismKB 2.0

Annotation Details for NFKB1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NFKB1 ( DKFZp686C01211,EBP-1,KBF1,MGC54151,NF-kappa-B,NF-kappaB,NFKB-p105,NFKB-p50,p105,p50 )
Gene Full Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Band: 4q24
Quick LinksEntrez ID:4790; OMIM: 164011; Uniprot ID:NFKB1_HUMAN; ENSEMBL ID: ENSG00000109320; HGNC ID: 7794
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus11819787
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm11819787
GO:0005739IDA-mitochondrion-
GO:0005829IBA-cytosol-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0033256TAS-I-kappaB/NF-kappaB complex16938301
GO:0034774TAS-secretory granule lumen-
GO:0035580TAS-specific granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0000975IDA-regulatory region DNA binding17426251
GO:0000976IDA-transcription regulatory region sequence-specific DNA binding18718911
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding7959007
GO:0000980IDA-RNA polymerase II distal enhancer sequence-specific DNA binding1406630
GO:0001205IDA-transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding1406630
GO:0001227IDA-transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding24434510
GO:0003682IBA-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding17426251
GO:0005515IPI-protein binding8196632
GO:0008134IDA-transcription factor binding18270204
GO:0042802IPI-identical protein binding12482991
GO:0042803IEA-protein homodimerization activity-
GO:0042805IPI-actinin binding25411248
GO:0044212IDA-transcription regulatory region DNA binding16938301
GO:0046982IDA-protein heterodimerization activity7959007
GO ID Evidence Qualifier GO_term References
GO:0000122IC-negative regulation of transcription from RNA polymerase II promoter16938301
GO:0000122IGI-negative regulation of transcription from RNA polymerase II promoter24434150
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter19881551
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006366TAS-transcription from RNA polymerase II promoter1992489
GO:0006915IEA-apoptotic process-
GO:0006954TAS-inflammatory response1992489
GO:0007249IBA-I-kappaB kinase/NF-kappaB signaling-
GO:0010629IDA-negative regulation of gene expression26687115
GO:0010744IC-positive regulation of macrophage derived foam cell differentiation16938301
GO:0010884IC-positive regulation of lipid storage16938301
GO:0010956IDA-negative regulation of calcidiol 1-monooxygenase activity15243130
GO:0010957IC-negative regulation of vitamin D biosynthetic process15243130
GO:0031293TAS-membrane protein intracellular domain proteolysis-
GO:0032269IC-negative regulation of cellular protein metabolic process16938301
GO:0032375IC-negative regulation of cholesterol transport16938301
GO:0032481TAS-positive regulation of type I interferon production-
GO:0035994IEA-response to muscle stretch-
GO:0038061IBA-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043066TAS-negative regulation of apoptotic process10811897
GO:0043312TAS-neutrophil degranulation-
GO:0045083IEA-negative regulation of interleukin-12 biosynthetic process-
GO:0045087IBA-innate immune response-
GO:0045893IDA-positive regulation of transcription, DNA-templated17426251
GO:0045893IMP-positive regulation of transcription, DNA-templated20018240
GO:0045893NAS-positive regulation of transcription, DNA-templated8096091
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter1406630
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter19955433
GO:0050728IEA-negative regulation of inflammatory response-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051092TAS-positive regulation of NF-kappaB transcription factor activity-
GO:0051403TAS-stress-activated MAPK cascade-
GO:0071222IMP-cellular response to lipopolysaccharide23776175
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0071316IMP-cellular response to nicotine22357537
GO:0071347IEP-cellular response to interleukin-112958148
GO:0071354IMP-cellular response to interleukin-622357537
GO:0071359IEA-cellular response to dsRNA-
GO:0071375IMP-cellular response to peptide hormone stimulus22357537
GO:0090263IMP-positive regulation of canonical Wnt signaling pathway20018240
GO:1900127IDA-positive regulation of hyaluronan biosynthetic process17324121
GO:2000630IMP-positive regulation of miRNA metabolic process22357537
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NFKB1PARP110665216204234 Reconstituted Complex
NFKB1PARP111085716204234 Reconstituted Complex
NFKB1ANXA410680420237821 Affinity Capture-Western
NFKB1ANXA411085720237821 Affinity Capture-Western
NFKB1BCL31108578428580 10469655 14678988 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
NFKB1BCL31070748428580 10469655 14678988 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
NFKB1KLF510715314573617 Affinity Capture-Western
NFKB1KLF511085714573617 Affinity Capture-Western
NFKB1CEBPB1108571518839 Reconstituted Complex
NFKB1CEBPB1074801518839 Reconstituted Complex
NFKB1CHUK10756910469655 Affinity Capture-Western
NFKB1CHUK11085710469655 Affinity Capture-Western
NFKB1MAP3K81077199950430 14743216 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NFKB1MAP3K81108579950430 14743216 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NFKB1TSC22D310816511468175 Affinity Capture-Western; Reconstituted Complex
NFKB1TSC22D311085711468175 Affinity Capture-Western; Reconstituted Complex
NFKB1E2F11082019368006 Reconstituted Complex
NFKB1E2F11108579368006 Reconstituted Complex
NFKB1ELF11108577862168 9094628 Reconstituted Complex
NFKB1ELF11083127862168 9094628 Reconstituted Complex
NFKB1ELF311085711036073 Reconstituted Complex
NFKB1ELF310831411036073 Reconstituted Complex
NFKB1EP30010834711739381 14662860 Affinity Capture-Western; Biochemical Activity
NFKB1EP30011085711739381 14662860 Affinity Capture-Western; Biochemical Activity
NFKB1NR3C11091657823959 16380507 Affinity Capture-Western; Reconstituted Complex
NFKB1NR3C11108577823959 16380507 Affinity Capture-Western; Reconstituted Complex
NFKB1GSK3B10918711425860 Biochemical Activity
NFKB1GSK3B11085711425860 Biochemical Activity
NFKB1HDAC110931511931769 12972430 16319923 17827154 Affinity Capture-Western; Co-localization; Reconstituted Complex
NFKB1HDAC111085711931769 12972430 16319923 17827154 Affinity Capture-Western; Co-localization; Reconstituted Complex
NFKB1HDAC210931617827154 Affinity Capture-Western
NFKB1HDAC211085717827154 Affinity Capture-Western
NFKB1HMGB111085712604365 Reconstituted Complex
NFKB1HMGB110938912604365 Reconstituted Complex
NFKB1HMGA11094029809067 Reconstituted Complex
NFKB1HMGA11108579809067 Reconstituted Complex
NFKB1IRF81108578550813 Reconstituted Complex
NFKB1IRF81096218550813 Reconstituted Complex
NFKB1IKBKB10976710469655 11158290 Affinity Capture-Western; Biochemical Activity
NFKB1IKBKB11085710469655 11158290 Affinity Capture-Western; Biochemical Activity
NFKB1IRF21108578550813 Reconstituted Complex
NFKB1IRF21098688550813 Reconstituted Complex
NFKB1KPNA311003714743216 Affinity Capture-MS
NFKB1KPNA311085714743216 Affinity Capture-MS
NFKB1LYL111085710023675 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NFKB1LYL111024410023675 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NFKB1MEN111038411526476 16651450 Affinity Capture-Western; Reconstituted Complex
NFKB1MEN111085711526476 16651450 Affinity Capture-Western; Reconstituted Complex
TXNNFKB11108577788295 Co-crystal Structure
TXNNFKB11131467788295 Co-crystal Structure
SP1NFKB11108577933095 16740634 Affinity Capture-Western; Reconstituted Complex
SP1NFKB11125507933095 16740634 Affinity Capture-Western; Reconstituted Complex
NFKB1NFKB11108578428580 14743216 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex
IRF9NFKB11108578550813 Reconstituted Complex
IRF9NFKB11156528550813 Reconstituted Complex
NOTCH1NFKB11109138642313 11418662 Affinity Capture-Western; Reconstituted Complex
NOTCH1NFKB11108578642313 11418662 Affinity Capture-Western; Reconstituted Complex
RELANFKB11108578798655 14743216 16105840 16204234 16319923 16740634 20237821 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex
RELANFKB11119028798655 14743216 16105840 16204234 16319923 16740634 20237821 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex
NFKBIENFKB11108579315679 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NFKBIENFKB11108619315679 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1NFKB11108579556555 10847592 Reconstituted Complex
NCOA1NFKB11142009556555 10847592 Reconstituted Complex
STAT6NFKB11126559584180 Affinity Capture-Western; Reconstituted Complex
STAT6NFKB11108579584180 Affinity Capture-Western; Reconstituted Complex
NFKBIANFKB11108599738011 11313474 20237821 20980497 Affinity Capture-Western; Reconstituted Complex
NFKBIANFKB11108579738011 11313474 20237821 20980497 Affinity Capture-Western; Reconstituted Complex
PPP4CNFKB11115239837938 Affinity Capture-Western
PPP4CNFKB11108579837938 Affinity Capture-Western
RXRANFKB111085710075655 Reconstituted Complex
RXRANFKB111216810075655 Reconstituted Complex
NKRFNFKB112100210562553 Reconstituted Complex
NKRFNFKB111085710562553 Reconstituted Complex
TP53BP1NFKB111085710646849 Affinity Capture-Western
TP53BP1NFKB111301110646849 Affinity Capture-Western
NCOA6NFKB111085710847592 Reconstituted Complex
NCOA6NFKB111669110847592 Reconstituted Complex
BTRCNFKB111085711158290 12482991 Affinity Capture-Western; Reconstituted Complex
BTRCNFKB111445711158290 12482991 Affinity Capture-Western; Reconstituted Complex
NFKBIZNFKB111085711356851 Affinity Capture-Western
NFKBIZNFKB112213911356851 Affinity Capture-Western
MTPNNFKB111085711971907 Reconstituted Complex
MTPNNFKB112645511971907 Reconstituted Complex
STAT3NFKB111085712057007 Affinity Capture-Western; Reconstituted Complex
STAT3NFKB111265112057007 Affinity Capture-Western; Reconstituted Complex
NCOR1NFKB111085712150997 Affinity Capture-Western
NCOR1NFKB111497312150997 Affinity Capture-Western
TAB2NFKB111085712150997 Affinity Capture-Western; Reconstituted Complex
TAB2NFKB111674012150997 Affinity Capture-Western; Reconstituted Complex
ITGB3BPNFKB111085712244126 Affinity Capture-Western; Reconstituted Complex
ITGB3BPNFKB111699212244126 Affinity Capture-Western; Reconstituted Complex
HMGA2NFKB111085712693954 Far Western; Reconstituted Complex
HMGA2NFKB111376312693954 Far Western; Reconstituted Complex
HDAC3NFKB111085712972430 15494311 Affinity Capture-Western; Co-localization
HDAC3NFKB111436812972430 15494311 Affinity Capture-Western; Co-localization
CARM1NFKB111085714729568 Co-purification
CARM1NFKB111576014729568 Co-purification
TBK1NFKB111085714743216 Affinity Capture-MS
TBK1NFKB111887814743216 Affinity Capture-MS
NFKB2NFKB111085814743216 Affinity Capture-MS
NFKB2NFKB111085714743216 Affinity Capture-MS
RELNFKB111085714743216 Affinity Capture-MS
RELNFKB111189814743216 Affinity Capture-MS
RELBNFKB111085714743216 Affinity Capture-MS
RELBNFKB111190314743216 Affinity Capture-MS
TNIP2NFKB111085714743216 Affinity Capture-MS
TNIP2NFKB112257314743216 Affinity Capture-MS
TNIP3NFKB111085714743216 Affinity Capture-MS
TNIP3NFKB112300614743216 Affinity Capture-MS
IKBKGNFKB111085714743216 Affinity Capture-MS
IKBKGNFKB111408914743216 Affinity Capture-MS
SPAG9NFKB111085714743216 Affinity Capture-MS
SPAG9NFKB111450514743216 Affinity Capture-MS
COPB2NFKB111085714743216 Affinity Capture-MS
COPB2NFKB111469314743216 Affinity Capture-MS
UNC5CLNFKB111085714769797 Affinity Capture-Western
UNC5CLNFKB112880814769797 Affinity Capture-Western
RSF1NFKB111085715242768 Affinity Capture-Western
RSF1NFKB111972415242768 Affinity Capture-Western
NCOR2NFKB111085715494311 Co-localization
NCOR2NFKB111497415494311 Co-localization
POLR2ANFKB111085716319923 Co-localization
POLR2ANFKB111142616319923 Co-localization
BRMS1NFKB111085717000776 Affinity Capture-Western
BRMS1NFKB111737917000776 Affinity Capture-Western
SUMO1NFKB111085717549794 Affinity Capture-MS
SUMO1NFKB111318817549794 Affinity Capture-MS
PSMD10NFKB111085717904523 Affinity Capture-Western; Reconstituted Complex
PSMD10NFKB111168817904523 Affinity Capture-Western; Reconstituted Complex
RPS3NFKB111085718045535 Affinity Capture-Western
RPS3NFKB111210218045535 Affinity Capture-Western
BANPNFKB111085718981184 Affinity Capture-Western
BANPNFKB112030818981184 Affinity Capture-Western
ZFP36NFKB111337019738286 Affinity Capture-Western
ZFP36NFKB111085719738286 Affinity Capture-Western
ZBTB9NFKB111085720211142 Two-hybrid
ZBTB9NFKB112873620211142 Two-hybrid
PCBD1NFKB111085720211142 Two-hybrid
PCBD1NFKB111112520211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
NFKB1NFKB1_1537T/C Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:97312
  • Data Attributes: MGI curated and HomoloGene calculated
No data