AutismKB 2.0

Annotation Details for NKX2-2


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Basic Information Top
Gene Symbol:NKX2-2 ( NKX2.2,NKX2B )
Gene Full Name: NK2 homeobox 2
Band: 20p11.22
Quick LinksEntrez ID:4821; OMIM: 604612; Uniprot ID:NKX22_HUMAN; ENSEMBL ID: ENSG00000125820; HGNC ID: 7835
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO ID Evidence Qualifier GO_term References
GO:0001159ISS-core promoter proximal region DNA binding-
GO:0003682ISS-chromatin binding-
GO:0003700IEA-transcription factor activity, sequence-specific DNA binding-
GO:0003713ISS-transcription coactivator activity-
GO:0008134IEA-transcription factor binding-
GO:0043565IEA-sequence-specific DNA binding-
GO ID Evidence Qualifier GO_term References
GO:0003323IEA-type B pancreatic cell development-
GO:0003326IEA-pancreatic A cell fate commitment-
GO:0003327IEA-type B pancreatic cell fate commitment-
GO:0003329IEA-pancreatic PP cell fate commitment-
GO:0006351IEA-transcription, DNA-templated-
GO:0007224IEA-smoothened signaling pathway-
GO:0007420TAS-brain development1346742
GO:0009749IEA-response to glucose-
GO:0014003IEA-oligodendrocyte development-
GO:0021522IEA-spinal cord motor neuron differentiation-
GO:0021530IEA-spinal cord oligodendrocyte cell fate specification-
GO:0021554IEA-optic nerve development-
GO:0031018TAS-endocrine pancreas development-
GO:0032570IEA-response to progesterone-
GO:0045665IEA-negative regulation of neuron differentiation-
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048565IEA-digestive tract development-
GO:0048665IEA-neuron fate specification-
GO:0048708IEA-astrocyte differentiation-
GO:0048714IEA-positive regulation of oligodendrocyte differentiation-
GO:0051091ISS-positive regulation of sequence-specific DNA binding transcription factor activity-
GO:0060580IEA-ventral spinal cord interneuron fate determination-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NKX2-2HDAC110931515695521 Affinity Capture-Western
NKX2-2HDAC111088615695521 Affinity Capture-Western
SIN3ANKX2-211743915695521 Affinity Capture-Western
SIN3ANKX2-211088615695521 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97347
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050217-3'