AutismKB 2.0

Annotation Details for NKX3-1


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Basic Information Top
Gene Symbol:NKX3-1 ( BAPX2,NKX3,NKX3.1,NKX3A )
Gene Full Name: NK3 homeobox 1
Band: 8p21.2
Quick LinksEntrez ID:4824; OMIM: 602041; Uniprot ID:NKX31_HUMAN; ENSEMBL ID: ENSG00000167034; HGNC ID: 7838
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IDA-intracellular19597465
GO:0005634IC-nucleus20855495
GO:0005634IDA-nucleus18757402
GO:0005634NAS-nucleus11137288
GO ID Evidence Qualifier GO_term References
GO:0000976IDA-transcription regulatory region sequence-specific DNA binding20855495
GO:0000983IEA-transcription factor activity, RNA polymerase II core promoter sequence-specific-
GO:0001047IDA-core promoter binding18974119
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding20855495
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding11137288
GO:0004882IDA-androgen receptor activity19886863
GO:0005515IPI-protein binding17234752
GO:0008134IPI-transcription factor binding20716579
GO:0008656IDAcontributes_tocysteine-type endopeptidase activator activity involved in apoptotic process19266349
GO:0030284IDA-estrogen receptor activity18794125
GO:0030295IDA-protein kinase activator activity20395202
GO:0030331IDA-estrogen receptor binding18794125
GO:0042826IPI-histone deacetylase binding18974119
GO:0043565IDA-sequence-specific DNA binding19780584
GO:0043621IDA-protein self-association19780584
GO:0044212IDA-transcription regulatory region DNA binding19263243
GO:0097162IEA-MADS box domain binding-
GO ID Evidence Qualifier GO_term References
GO:0001656IEA-metanephros development-
GO:0001756IEA-somitogenesis-
GO:0001934IDA-positive regulation of protein phosphorylation20395202
GO:0006351IEA-transcription, DNA-templated-
GO:0006355NAS-regulation of transcription, DNA-templated11137288
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process17486276
GO:0007275TAS-multicellular organism development9537602
GO:0007431ISS-salivary gland development-
GO:0007507IEA-heart development-
GO:0008284IMP-positive regulation of cell proliferation18360715
GO:0008285IDA-negative regulation of cell proliferation17486276
GO:0008584IEA-male gonad development-
GO:0010628IDA-positive regulation of gene expression17486276
GO:0010628IMP-positive regulation of gene expression20716579
GO:0010629IDA-negative regulation of gene expression17486276
GO:0010942IDA-positive regulation of cell death19266349
GO:0014068IDA-positive regulation of phosphatidylinositol 3-kinase signaling20395202
GO:0030521IDA-androgen receptor signaling pathway19886863
GO:0032147IEA-activation of protein kinase activity-
GO:0033574ISS-response to testosterone-
GO:0035690IEP-cellular response to drug18757402
GO:0035907IEA-dorsal aorta development-
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process20599703
GO:0043491IMP-protein kinase B signaling19597465
GO:0043569ISS-negative regulation of insulin-like growth factor receptor signaling pathway-
GO:0045892IDA-negative regulation of transcription, DNA-templated18794125
GO:0045892IMP-negative regulation of transcription, DNA-templated18360715
GO:0045893IMP-positive regulation of transcription, DNA-templated18360715
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045930IDA-negative regulation of mitotic cell cycle19266349
GO:0045931IMP-positive regulation of mitotic cell cycle20855495
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter19797053
GO:0048754ISS-branching morphogenesis of an epithelial tube-
GO:0050680ISS-negative regulation of epithelial cell proliferation-
GO:0051781IMP-positive regulation of cell division20855495
GO:0060037IEA-pharyngeal system development-
GO:0060442ISS-branching involved in prostate gland morphogenesis-
GO:0060664ISS-epithelial cell proliferation involved in salivary gland morphogenesis-
GO:0060770ISS-negative regulation of epithelial cell proliferation involved in prostate gland development-
GO:0071347IEP-cellular response to interleukin-118757402
GO:0071356IEP-cellular response to tumor necrosis factor18757402
GO:0071383IDA-cellular response to steroid hormone stimulus19886863
GO:0071456IDA-cellular response to hypoxia21056661
GO:0071850IDA-mitotic cell cycle arrest19266349
GO:0071899IDA-negative regulation of estrogen receptor binding18794125
GO:2000836IDA-positive regulation of androgen secretion19886863
GO:2001022IDA-positive regulation of response to DNA damage stimulus20395202
GO:2001235IDA-positive regulation of apoptotic signaling pathway20599703
GO:2001244IDA-positive regulation of intrinsic apoptotic signaling pathway17486276
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NKX3-1HDAC110931516697957 Affinity Capture-Western
NKX3-1HDAC111088816697957 Affinity Capture-Western
SRFNKX3-111260010993896 Affinity Capture-Western
SRFNKX3-111088810993896 Affinity Capture-Western
SPDEFNKX3-111733511809674 Affinity Capture-Western; Two-hybrid
SPDEFNKX3-111088811809674 Affinity Capture-Western; Two-hybrid
SP5NKX3-113295116201967 Two-hybrid
SP5NKX3-111088816201967 Two-hybrid
SP1NKX3-111255016201967 Two-hybrid
SP1NKX3-111088816201967 Two-hybrid
SP2NKX3-111255116201967 Two-hybrid
SP2NKX3-111088816201967 Two-hybrid
SP3NKX3-111255316201967 Two-hybrid
SP3NKX3-111088816201967 Two-hybrid
SP4NKX3-111255416201967 Two-hybrid
SP4NKX3-111088816201967 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97352
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081104-238'