AutismKB 2.0

Annotation Details for NOS1


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Basic Information Top
Gene Symbol:NOS1 ( IHPS1,N-NOS,NC-NOS,NOS,bNOS,nNOS )
Gene Full Name: nitric oxide synthase 1 (neuronal)
Band: 12q24.22
Quick LinksEntrez ID:4842; OMIM: 163731; Uniprot ID:NOS1_HUMAN; ENSEMBL ID: ENSG00000089250; HGNC ID: 7872
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001917ISS-photoreceptor inner segment17027776
GO:0005654IDA-nucleoplasm-
GO:0005737TAS-cytoplasm17892502
GO:0005739ISS-mitochondrion-
GO:0005829TAS-cytosol-
GO:0005856ISS-cytoskeleton7545544
GO:0005886IDA-plasma membrane-
GO:0005901IEA-caveola-
GO:0016529IDA-sarcoplasmic reticulum9892689
GO:0030018IEA-Z disc-
GO:0030315IEA-T-tubule-
GO:0042383IDA-sarcolemma7545544
GO:0043197IEA-dendritic spine-
GO:0043234ISS-protein complex-
GO:0045121ISS-membrane raft-
GO:0045202ISS-synapse-
GO:0048471ISS-perinuclear region of cytoplasm17027776
GO:1990425TAScolocalizes_withryanodine receptor complex21536106
GO ID Evidence Qualifier GO_term References
GO:0003958IBA-NADPH-hemoprotein reductase activity-
GO:0004517IDA-nitric-oxide synthase activity1689048
GO:0004517ISS-nitric-oxide synthase activity7545544
GO:0004517TAS-nitric-oxide synthase activity-
GO:0005506IEA-iron ion binding-
GO:0005515IPI-protein binding11149895
GO:0005516IEA-calmodulin binding-
GO:0010181ISS-FMN binding-
GO:0017080ISS-sodium channel regulator activity-
GO:0020037ISS-heme binding-
GO:0034617NAS-tetrahydrobiopterin binding7488039
GO:0034618TAS-arginine binding17029414
GO:0044325ISS-ion channel binding-
GO:0044325TAS-ion channel binding21536106
GO:0046870ISS-cadmium ion binding-
GO:0050660ISS-flavin adenine dinucleotide binding-
GO:0050661ISS-NADP binding-
GO:0097110ISS-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001666IEP-response to hypoxia16276418
GO:0002028ISS-regulation of sodium ion transport-
GO:0006527IC-arginine catabolic process7545544
GO:0006809ISS-nitric oxide biosynthetic process7545544
GO:0006941ISS-striated muscle contraction-
GO:0007263IBA-nitric oxide mediated signal transduction-
GO:0007520TAS-myoblast fusion7545544
GO:0009408IDA-response to heat18048451
GO:0010523TAS-negative regulation of calcium ion transport into cytosol17568574
GO:0018119ISS-peptidyl-cysteine S-nitrosylation-
GO:0031284IBA-positive regulation of guanylate cyclase activity-
GO:0033555IMP-multicellular organismal response to stress18391107
GO:0035066ISS-positive regulation of histone acetylation-
GO:0042136TAS-neurotransmitter biosynthetic process7545544
GO:0042311IDA-vasodilation18048451
GO:0042311IMP-vasodilation18391107
GO:0042738ISS-exogenous drug catabolic process-
GO:0043267ISS-negative regulation of potassium ion transport-
GO:0045454TAS-cell redox homeostasis-
GO:0045776IBA-negative regulation of blood pressure-
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0050767IEA-regulation of neurogenesis-
GO:0051346ISS-negative regulation of hydrolase activity-
GO:0051612ISS-negative regulation of serotonin uptake-
GO:0051926ISS-negative regulation of calcium ion transport-
GO:0055114IEA-oxidation-reduction process-
GO:0055117TAS-regulation of cardiac muscle contraction9892689
GO:0060314TAS-regulation of ryanodine-sensitive calcium-release channel activity21536106
GO:0071363ISS-cellular response to growth factor stimulus-
GO:0098735ISS-positive regulation of the force of heart contraction-
GO:0098924IEA-retrograde trans-synaptic signaling by nitric oxide-
GO:1901205TAS-negative regulation of adrenergic receptor signaling pathway involved in heart process21536106
GO:1901206IEA-positive regulation of adrenergic receptor signaling pathway involved in heart process-
GO:1902307ISS-positive regulation of sodium ion transmembrane transport-
GO:1902514TAS-regulation of calcium ion transmembrane transport via high voltage-gated calcium channel21536106
GO:1903779TAS-regulation of cardiac conduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NOS1BDKRB211090510681501 Affinity Capture-Western
NOS1BDKRB210709310681501 Affinity Capture-Western
NOS1DLG21080848625413 Two-hybrid
NOS1DLG21109058625413 Two-hybrid
NOS1DLG41109058625413 9459447 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
NOS1DLG41080868625413 9459447 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
NOS1HSPA411090515466472 Affinity Capture-Western
NOS1HSPA410954015466472 Affinity Capture-Western
SNTA1NOS11109059412493 Reconstituted Complex
SNTA1NOS11125239412493 Reconstituted Complex
NOS1APNOS11109059459447 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NOS1APNOS11150719459447 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RASD1NOS111090511086993 Reconstituted Complex
RASD1NOS111966211086993 Reconstituted Complex
PTPN6NOS111174211511520 Affinity Capture-Western
PTPN6NOS111090511511520 Affinity Capture-Western
SYN1NOS111090511867766 Reconstituted Complex
SYN1NOS111271911867766 Reconstituted Complex
ZDHHC23NOS111090515105416 Affinity Capture-Western; Reconstituted Complex
ZDHHC23NOS112905615105416 Affinity Capture-Western; Reconstituted Complex
UBCNOS111316415466472 Affinity Capture-Western
UBCNOS111090515466472 Affinity Capture-Western
STUB1NOS111090515466472 Affinity Capture-Western; Biochemical Activity
STUB1NOS111556315466472 Affinity Capture-Western; Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
NOS1NOS1_CArep, NOS1_G84A, NOS1_VNTR, rs2682826 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
NOS1rs1047735, rs10774910, rs11068447, rs1123425, rs11611788, rs12578547, rs12829185, rs1483757, rs1520811, rs1552227, rs1552228, rs2293052, rs2293054, rs2293055, rs2682826, rs3741475, rs3782218, rs3782221, rs4767523, rs478597, rs545654, rs547954, rs561712, rs693534, rs7139256, rs72309850, rs7295972, rs816354 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
NOS1NOS1_-84A/G, NOS1_STR, rs1047735, rs1879417, rs2133681, rs2293051, rs2293054, rs2682826, rs3741473, rs3782206, rs3782219, rs3782221, rs3837437, rs41279104, rs4767540, rs499776, rs532967, rs561712, rs6490121, rs816363 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97360
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-001101-1'