Gene Symbol:	NOS2 ( HEP-NOS,INOS,NOS,NOS2A )
Gene Full Name:	nitric oxide synthase 2, inducible
Band:	17q11.2
Quick Links	Entrez ID:4843; OMIM: 163730; Uniprot ID:NOS2_HUMAN; ENSEMBL ID: ENSG00000007171; HGNC ID: 7873
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005622	IDA	-	intracellular	7544003
GO:0005634	ISS	-	nucleus	-
GO:0005737	IDA	-	cytoplasm	9916929
GO:0005777	IDA	-	peroxisome	12085352
GO:0005829	IMP	-	cytosol	7504305
GO:0005829	TAS	-	cytosol	-
GO:0030863	IEA	-	cortical cytoskeleton	-
GO:0048471	IEA	-	perinuclear region of cytoplasm	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003958	IBA	-	NADPH-hemoprotein reductase activity	-
GO:0004517	IDA	-	nitric-oxide synthase activity	7504305
GO:0004517	TAS	-	nitric-oxide synthase activity	-
GO:0005102	IPI	-	receptor binding	20178365
GO:0005506	IEA	-	iron ion binding	-
GO:0005515	IPI	-	protein binding	12855682
GO:0005516	IEA	-	calmodulin binding	-
GO:0010181	ISS	-	FMN binding	-
GO:0020037	ISS	-	heme binding	-
GO:0034617	ISS	-	tetrahydrobiopterin binding	-
GO:0034618	ISS	-	arginine binding	-
GO:0042803	ISS	-	protein homodimerization activity	-
GO:0050660	ISS	-	flavin adenine dinucleotide binding	-
GO:0050661	TAS	-	NADP binding	7504305

GO ID	Evidence	Qualifier	GO_term	References
GO:0001666	IEA	-	response to hypoxia	-
GO:0001912	TAS	-	positive regulation of leukocyte mediated cytotoxicity	10450191
GO:0002227	NAS	-	innate immune response in mucosa	18390757
GO:0006527	IDA	-	arginine catabolic process	7504305
GO:0006801	ISS	-	superoxide metabolic process	-
GO:0006809	IDA	-	nitric oxide biosynthetic process	7504305
GO:0007263	IBA	-	nitric oxide mediated signal transduction	-
GO:0007623	IEA	-	circadian rhythm	-
GO:0009617	NAS	-	response to bacterium	12085352
GO:0010629	IGI	-	negative regulation of gene expression	12085352
GO:0018119	ISS	-	peptidyl-cysteine S-nitrosylation	-
GO:0031284	IBA	-	positive regulation of guanylate cyclase activity	-
GO:0032310	IDA	-	prostaglandin secretion	19688109
GO:0035690	IEA	-	cellular response to drug	-
GO:0042127	IEA	-	regulation of cell proliferation	-
GO:0042177	IEA	-	negative regulation of protein catabolic process	-
GO:0042742	IMP	-	defense response to bacterium	9284131
GO:0042742	ISS	-	defense response to bacterium	-
GO:0043457	TAS	-	regulation of cellular respiration	10450191
GO:0045454	TAS	-	cell redox homeostasis	-
GO:0045776	IBA	-	negative regulation of blood pressure	-
GO:0050796	IMP	-	regulation of insulin secretion	8383325
GO:0050829	NAS	-	defense response to Gram-negative bacterium	18390757
GO:0051712	IMP	-	positive regulation of killing of cells of other organism	7544003
GO:0055114	IEA	-	oxidation-reduction process	-
GO:0071222	IEA	-	cellular response to lipopolysaccharide	-
GO:0071346	IEA	-	cellular response to interferon-gamma	-
GO:0072604	IDA	-	interleukin-6 secretion	19688109
GO:0072606	IDA	-	interleukin-8 secretion	19688109
GO:1900015	IDA	-	regulation of cytokine production involved in inflammatory response	19688109

Gene Symbol	Interactant	Interaction ID	References	Description
NOS2	CAV1	107305	11114180	Co-fractionation; Reconstituted Complex
NOS2	CAV1	110906	11114180	Co-fractionation; Reconstituted Complex
RAC2	NOS2	111818	11457725	Affinity Capture-Western; Reconstituted Complex
RAC2	NOS2	110906	11457725	Affinity Capture-Western; Reconstituted Complex
RAC1	NOS2	111817	11457725	Reconstituted Complex
RAC1	NOS2	110906	11457725	Reconstituted Complex
SLC9A3R1	NOS2	114769	12080081	Reconstituted Complex
SLC9A3R1	NOS2	110906	12080081	Reconstituted Complex

AutismKB 2.0

Annotation Details for NOS2