Gene Symbol:	NOS3 ( ECNOS,eNOS )
Gene Full Name:	nitric oxide synthase 3 (endothelial cell)
Band:	7q36.1
Quick Links	Entrez ID:4846; OMIM: 163729; Uniprot ID:NOS3_HUMAN; ENSEMBL ID: ENSG00000164867; HGNC ID: 7876
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000139	TAS	-	Golgi membrane	-
GO:0005634	ISS	-	nucleus	-
GO:0005737	IDA	-	cytoplasm	9794441
GO:0005829	TAS	-	cytosol	-
GO:0005856	IEA	-	cytoskeleton	-
GO:0005886	TAS	-	plasma membrane	-
GO:0005901	IDA	-	caveola	17502619
GO:0030666	TAS	-	endocytic vesicle membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003785	IPI	-	actin monomer binding	17502619
GO:0003958	IBA	-	NADPH-hemoprotein reductase activity	-
GO:0004517	IDA	-	nitric-oxide synthase activity	1378832
GO:0004517	IMP	-	nitric-oxide synthase activity	23707606
GO:0004517	TAS	-	nitric-oxide synthase activity	-
GO:0005506	IEA	-	iron ion binding	-
GO:0005515	IPI	-	protein binding	11149895
GO:0005516	IEA	-	calmodulin binding	-
GO:0010181	NAS	-	FMN binding	7488039
GO:0020037	IDA	-	heme binding	7488039
GO:0034617	IDA	-	tetrahydrobiopterin binding	7488039
GO:0034618	IDA	-	arginine binding	7488039
GO:0046870	NAS	-	cadmium ion binding	7488039
GO:0050660	NAS	-	flavin adenine dinucleotide binding	7488039
GO:0050661	NAS	-	NADP binding	7488039
GO:0097110	IEA	-	scaffold protein binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001525	IEA	-	angiogenesis	-
GO:0001542	IEA	-	ovulation from ovarian follicle	-
GO:0001701	IEA	-	in utero embryonic development	-
GO:0001974	ISS	-	blood vessel remodeling	-
GO:0002028	IEA	-	regulation of sodium ion transport	-
GO:0003057	IEA	-	regulation of the force of heart contraction by chemical signal	-
GO:0003100	IMP	-	regulation of systemic arterial blood pressure by endothelin	8999856
GO:0006527	IDA	-	arginine catabolic process	1378832
GO:0006809	IDA	-	nitric oxide biosynthetic process	1378832
GO:0007005	ISS	-	mitochondrion organization	-
GO:0007263	IBA	-	nitric oxide mediated signal transduction	-
GO:0008217	NAS	-	regulation of blood pressure	7504210
GO:0008285	ISS	-	negative regulation of cell proliferation	-
GO:0009408	NAS	-	response to heat	18048451
GO:0010544	NAS	-	negative regulation of platelet activation	7504210
GO:0014740	ISS	-	negative regulation of muscle hyperplasia	-
GO:0014806	ISS	-	smooth muscle hyperplasia	-
GO:0019430	IDA	-	removal of superoxide radicals	19666465
GO:0030324	IEA	-	lung development	-
GO:0031284	IMP	-	positive regulation of guanylate cyclase activity	17502619
GO:0031284	ISS	-	positive regulation of guanylate cyclase activity	-
GO:0031663	IEA	-	lipopolysaccharide-mediated signaling pathway	-
GO:0034405	IEP	-	response to fluid shear stress	10376603
GO:0042311	NAS	-	vasodilation	7504210
GO:0043267	IEA	-	negative regulation of potassium ion transport	-
GO:0043542	IMP	-	endothelial cell migration	8999856
GO:0045454	TAS	-	cell redox homeostasis	-
GO:0045766	ISS	-	positive regulation of angiogenesis	-
GO:0045776	IBA	-	negative regulation of blood pressure	-
GO:0050880	ISS	-	regulation of blood vessel size	-
GO:0050999	TAS	-	regulation of nitric-oxide synthase activity	-
GO:0051346	IEA	-	negative regulation of hydrolase activity	-
GO:0051926	IEA	-	negative regulation of calcium ion transport	-
GO:0055114	IEA	-	oxidation-reduction process	-
GO:1902042	ISS	-	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-

Gene Symbol	Interactant	Interaction ID	References	Description
NOS3	CAV1	107305	8910295	Affinity Capture-Western
NOS3	CAV1	110909	8910295	Affinity Capture-Western
NOS3	GUCY1B3	109238	12676772	Affinity Capture-Western; Reconstituted Complex
NOS3	GUCY1B3	110909	12676772	Affinity Capture-Western; Reconstituted Complex
NOS3	HSP90AA1	110909	11744239 12124224 12676772	Affinity Capture-Western; Reconstituted Complex
NOS3	HSP90AA1	109552	11744239 12124224 12676772	Affinity Capture-Western; Reconstituted Complex
NOSTRIN	NOS3	125446	12446846	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
NOSTRIN	NOS3	110909	12446846	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for NOS3