AutismKB 2.0

Annotation Details for NOTCH2


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Basic Information Top
Gene Symbol:NOTCH2 ( AGS2,hN2 )
Gene Full Name: notch 2
Band: 1p12
Quick LinksEntrez ID:4853; OMIM: 600275; Uniprot ID:NOTC2_HUMAN; ENSEMBL ID: ENSG00000134250; HGNC ID: 7882
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus1303260
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane9244302
GO:0009986IDA-cell surface9244302
GO:0016020IDA-membrane19946888
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004872NAS-receptor activity9244302
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding10079256
GO:0038049TAS-transcription factor activity, ligand-activated RNA polymerase II transcription factor binding9244302
GO ID Evidence Qualifier GO_term References
GO:0001709TAS-cell fate determination9244302
GO:0002315ISS-marginal zone B cell differentiation-
GO:0003184IMP-pulmonary valve morphogenesis16773578
GO:0006355TAS-regulation of transcription, DNA-templated9244302
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006915TAS-apoptotic process12531696
GO:0007050IDA-cell cycle arrest11306509
GO:0007219IDA-Notch signaling pathway25985737
GO:0007219TAS-Notch signaling pathway-
GO:0007275NAS-multicellular organism development9244302
GO:0007399NAS-nervous system development12760378
GO:0008285IDA-negative regulation of cell proliferation11306509
GO:0009887IEP-animal organ morphogenesis12531696
GO:0016049IDA-cell growth11306509
GO:0019827TAS-stem cell population maintenance11306509
GO:0030097TAS-hemopoiesis1303260
GO:0030522IEA-intracellular receptor signaling pathway-
GO:0043066TAS-negative regulation of apoptotic process12531696
GO:0046579IDA-positive regulation of Ras protein signal transduction11306509
GO:0046849IMP-bone remodeling21378985
GO:0050793IEA-regulation of developmental process-
GO:0060413IMP-atrial septum morphogenesis16773578
GO:0061314IC-Notch signaling involved in heart development16773578
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NOTCH2JAG111091510551863 10958687 11346656 Affinity Capture-Western; Reconstituted Complex
NOTCH2JAG110668910551863 10958687 11346656 Affinity Capture-Western; Reconstituted Complex
NOTCH2CNTN111091514567914 Affinity Capture-Western
NOTCH2CNTN110767214567914 Affinity Capture-Western
NOTCH2GSK3B11091512794074 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NOTCH2GSK3B10918712794074 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NOTCH2RBPJ1097369032325 Two-hybrid
NOTCH2RBPJ1109159032325 Two-hybrid
NOTCH2JAG211091510958687 Affinity Capture-Western; Reconstituted Complex
NOTCH2JAG210991810958687 Affinity Capture-Western; Reconstituted Complex
DLL1NOTCH21183919244302 10958687 11346656 Affinity Capture-Western; Reconstituted Complex
DLL1NOTCH21109159244302 10958687 11346656 Affinity Capture-Western; Reconstituted Complex
MAML1NOTCH211091511101851 Reconstituted Complex
MAML1NOTCH211513811101851 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
NOTCH2rs8002, rs835574 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97364
  • Data Attributes: MGI curated and HomoloGene calculated
No data